Show simple item record

dc.contributor.authorTopçu, Gülaçtı
dc.contributor.authorAlim Toraman, Gülbahar Özge
dc.contributor.authorŞenol, Halil
dc.contributor.authorAltan, Vecdi Melih
dc.date.accessioned2020-12-09T20:59:08Z
dc.date.available2020-12-09T20:59:08Z
dc.date.issued2020-12-01T00:00:00Z
dc.identifier.citationTopçu G., Şenol H., Alim Toraman G. Ö. , Altan V. M. , -Natural Alkaloids as Potential Anti-Coronavirus Compounds-, Bezmialem Science, cilt.8, ss.131-139, 2020
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27657
dc.description.abstractCoronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.
dc.subjectCOVID-19
dc.titleNatural Alkaloids as Potential Anti-Coronavirus Compounds
dc.typeArticle
dc.identifier.wos000613758900011
dc.identifier.doi10.14235/bas.galenos.2020.5035
local.publication.isinternational1
dc.contributor.institutionauthor ALİM TORAMAN, Gülbahar Özge
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorŞENOL, Halil
dc.contributor.institutionauthorALTAN, VECDİ MELİH


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record