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Natural Alkaloids as Potential Anti-Coronavirus Compounds

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dc.contributor.authorTopçu, Gülaçtı
dc.contributor.authorŞenol, Halil
dc.contributor.authorAlim Toraman, Gülbahar Özge
dc.contributor.authorAltan, Vecdi Melih
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorŞENOL, HALIL
dc.contributor.institutionauthorALİM TORAMAN, GÜLBAHAR ÖZGE
dc.contributor.institutionauthorALTAN, VECDİ MELİH
dc.date.accessioned2020-12-09T20:59:08Z
dc.date.available2020-12-09T20:59:08Z
dc.date.issued2020-12-01T00:00:00Z
dc.description.abstractCoronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.
dc.identifier.citationTopçu G, Şenol H, Alim Toraman GÖ, Altan VM. Natural Alkaloids as Potential Anticoronavirus Compounds. Bezmialem Science 2020;8(Supplement 3):131-9.
dc.identifier.doi10.14235/bas.galenos.2020.5035
dc.identifier.trdizin485127
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27657
dc.identifier.wosWOS:000613758900011
dc.subjectCOVID-19
dc.subjectAntiviral
dc.subjectalkaloids
dc.subjectcoronaviruses
dc.subjectSARS-CoV-2
dc.subjectnatural products
dc.titleNatural Alkaloids as Potential Anti-Coronavirus Compounds
dc.typeArticle
dspace.entity.typePublication
local.avesis.id609a7ce1-ec7a-4a66-bf44-f482e5e72242
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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