Person: ALİM TORAMAN, GÜLBAHAR ÖZGE
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ALİM TORAMAN
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GÜLBAHAR ÖZGE
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- PublicationMetadata onlyGC-MS and LC-MS Analyses of a Brown Algae Cladostephus spongiosus Extracts with Bioactivity Studies(2021-12-08T00:00:00Z) Atasoy, Sezen; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; ATASOY, SEZEN; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyCentaurea nemecii NAB. Ekstrelerinin Antikolinesteraz İnhibitör Aktivitesi(2021-12-08T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Bütün, Burcu; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
- PublicationOpen AccessNatural Alkaloids as Potential Anti-Coronavirus Compounds(2020-12-01T00:00:00Z) Topçu, Gülaçtı; Şenol, Halil; Alim Toraman, Gülbahar Özge; Altan, Vecdi Melih; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGE; ALTAN, VECDİ MELİHCoronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.
- PublicationMetadata onlyBazı Salvia Türleri Üzerinde Yapılan Klinik Araştırmalar(2021-11-19T00:00:00Z) Alim Toraman, Gülbahar Özge; Kuşman Sayğı, Tuba; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
- PublicationOpen AccessAnti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles(2022-10-01T00:00:00Z) Erol, Ebru; Alim Toraman, Gulbahar Ozge; Orhan, Muge Didem; Avsar, Timucin; Akdemir, Atilla; Okudan, Emine Sukran; Topcu, Gulacti; EROL, EBRU; AKDEMİR, ATİLLA; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIAbstractCaulerpa cylindraceaSonder is a green alga belonging to the Caulerpaceae family. This is the first chemical investigation ofC. cylindraceain the Dardanelles which resulted in the isolation of four compounds, caulerpin (1), monomethyl caulerpinate (2), beta-sitosterol (3), and palmitic acid (4). Their structures were elucidated by spectroscopic analyses including 1D- and 2D NMR and mass. The isolated compounds1and2were tested against the SARS-CoV-2 viral targets spike protein and main protease (3CL) enzyme, and both compounds significantly inhibit the interaction of spike protein and ACE2, while the main protease activity was not significantly reduced. Docking studies suggested that compounds1and2may bind to the ACE2 binding pocket on spike, and compound2may also bind to an allosteric site on spike. As such, these compounds may inhibit the spike–ACE2 complex formation competitively and/or allosterically and have the potential to be used against SARS-CoV-2 virus infection. In addition, compounds1and2showed at least two-fold higher cytotoxicity against breast cancer cell lines MCF7 and MDA-MB-231 compared to the CCD fibroblast control cell line.
- PublicationMetadata onlyAromaterapi(2021-01-01T00:00:00Z) TOPÇU, GÜLAÇTI; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI; ALİM TORAMAN, GÜLBAHAR ÖZGE
- PublicationMetadata onlySalvia sericeo-tomentosa var. sericeo-tomentosa ve Salvia sericeo-tomentosa var. hatayica taksonlarının polar ekstrelerinin kimyasal içeriği ve antidiyabetik aktivitelerinin belirlenmesi(2022-06-26T00:00:00Z) Alim Toraman, Gülbahar Özge; Tan, Nur; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyAdaçayı Yaprağı, Kara Şalba(2018-10-01) Tan, Nur; Yazıcı Tütüniş, Seçil; Yeşil, Yeter; Ekinci, Miraç; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyCatechic Tannin Content of Different Tea Samples(2022-06-01T00:00:00Z) Alim Toraman, Gülbahar Özge; Tan, Nur; ALİM TORAMAN, GÜLBAHAR ÖZGE
- PublicationMetadata onlyDi-, and Triterpenoids Isolation and LC-MS Analysis of Salvia marashica Extracts with Bioactivity Studies(2021-11-01T00:00:00Z) Toraman, Gulbahar O. Alim; Aydin, Sibel Kiran; Ertas, Abdulselam; Boga, Mehmet; EROL, EBRU; Saygi, Tuba Kusman; Halfon, Belkis; TOPÇU, GÜLAÇTI; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTIIn this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salvia marashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of these extracts were determined as pyrocatechol equivalent and total flavonoids as quercetin equivalent. Antioxidant activity was determined by four complementary methods including inhibition of lipid peroxidation (by beta-carotene color expression), DPPH free radical scavenging activity, ABTS cation radical scavenging activity and CUPRAC methods. Anticholinesterase activity of the extracts was investigated by the Ellman method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Viability and cytotoxic activity tests were carried out on the fibroblast L929 cells and cytotoxic A549 lung cancer cells, respectively. The triterpenoids and diterpenoids constitute the major secondary metabolites of the S. marashica acetone and methanol extracts isolated by chromatographic methods. Their structures were determined based on spectroscopic methods, namely NMR and mass analyses. Ten terpenoids were obtained from either acetone or methanol extracts of the S. marashica. Seven of them were triterpenoids, elucidated as lupeol, lupeol-3-acetate, lup-12, 20(29)-diene, lup-20(29)-ene, alpha-amyrin-tetracosanoate, oleanolic acid and ursolic acid besides a steroid beta-sitosterol. Two abietane diterpenes, abieta-8,11,13-triene (1) and 18-acetoxymethylene-abieta-8,11,13-triene (2), were obtained from the acetone extract which were isolated from a Salvia species for the first time in the present study. The methanol extract was found to be very rich in rosmarinic acid determined by LC-MS/MS analysis.