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  • PublicationOpen Access
    The Treatment Role of Anti-aggregants and Anti-coagulants in Radial Artery Occlusion after Transradial Coronary Angiography
    (2023-07-01) Nadir A.; Uluganyan M.; NADİR, AYDIN; ULUGANYAN, MAHMUT
    Objective: The transradial approach (TRA) has been widely used for coronary procedures. The rate of complications such as bleeding, hematoma and pseudoaneurysm is reduced with TRA. The purpose of this study is to search the treatment role of anti-aggregants and low molecular weight heparins (LMWH) in situation of radial artery occlusion (RAO). Methods: A total of 239 patients (140 men, 58.6%) were included. Of the patients 159 (66.5%) were elective, and 80 (33.5%) had acute coronary syndrome. When RAO was detected, patients were treated with 2 weeks of LMWH. Results: In 23 (9.6%) of 239 patients, RAO was observed. From the 23 patients with RAO, 12 (52.8%) were using anti-aggregants, and the remaining 11 (47.8%) did not use. In terms of RAO, a statistically significant difference was observed between antiaggregant users and non-users (p<0.001). In the group using antiaggregants and LMWH a statistically significant improvement was observed in the radial flow compared with the group treated withLMWH alone (p<0.001). Conclusion: In the present study, we showed that the addition of anti-aggregants to anti-coagulants decreased RAO rate, declined the symptoms of RAO, also potentiated the effects of anti-coagulants and resulted in better recanalization rate of RAO
  • PublicationOpen Access
    Merkel Cell Carcinoma
    (2023-01-01) Sönmez Ergün, Selma ; Kirazoğlu, Ahmet; Akdemir, Osman Cemil; Su Küçük, Özlem; Altınok, Pelin; Yıldız, Pelin; ERGÜN, SELMA; AKDEMİR, OSMAN CEMİL; KİRAZOĞLU, AHMET; YILDIZ, PELİN; SU KÜÇÜK, ÖZLEM; ALTINOK SÜT, PELİN
    Merkel cell carcinoma (MCC) is a rare tumor that arises from mechanoreceptor Merkel cells. Ultraviolet exposure, immunosuppression and Merkel cell polyoma virus play a significant role in tumor pathogenesis. Although it typically presents as an initially indolent growing, painless solitary lesion, the course of MCC may be aggressive due to the nodal invasion, distant metastasis and high recurrence rates. We presented a case of MCC with a background history of rheumatoid arthritis treated with immunosuppressive therapy for many years who had necrotizing granulomatous lymphadenitis.
  • PublicationOpen Access
    Evaluation of the Relationship Between Maxillary Labial Frenulum Attachment Types, Periodontal Health, and Dental Caries in Preschool Children
    (2023-01-01) KINAY TARAN P.; ÖZDEMİR Ş.; AKARCA B.; Yüksel Ak H.; KINAY TARAN, PINAR; ÖZDEMİR, ŞERİFE
    Objective: The purpose of the study was to investigate any possible relation between maxillary labial frenulum attachment type on periodontal status and dental caries in pre14school children. Methods: This cross-sectional study was conducted for six months among the children who were admitted for treatment at a university clinic. The children aged between 3 to 6 years were enrolled in the study. The types of maxillary labial frenulum attachment were recorded as mucosal, gingival, papillary, and papillary penetrating types. Plaque index (PI), gingival index (GI), and dental status (dmft) of maxillary primary incisors were evaluated. Kruskal-Wallis and Pearson’s chi-squared tests were used for statistical analysis. Results: A total of 214 children (mean age was 4.4±0.9 years) were evaluated. The most common maxillary frenulum attachment type was the gingival type (45.8%), while the papillary penetrating type (13.1%) was the least common. The PI and GI scores in children with mucosal type frenulum were lower than in children with the gingival, papillary, and papillary penetrating types (p<0.01). The dmft scores were lower in children with mucosal type frenulum and higher in children with papillary type frenulum (p<0.01). Conclusion: Papillary and papillary penetrating types of frenulum attachments were associated with a decline in periodontal health and higher caries incidence in maxillary primary incisors.
  • PublicationOpen Access
    Comparison of Glasgow Blatchford and New Risk Scores to Predict Outcomes in Patients with Acute Upper GI Bleeding
    (2023-01-01) TAŞLIDERE B.; BİBERCİ KESKİN E.; ÖZDEMİR S.; Atsız A.; SÖNMEZ E.; TAŞLIDERE, BAHADIR; BİBERCİ KESKİN, ELMAS; SÖNMEZ, ERTAN
    Objective: Upper gastrointestinal (GI) bleeding constitutes a significant number of admissions to the emergency department, and it has high rates of morbidity and mortality. In this study, the contribution of new scores, such as The International Bleeding Risk Score (ABC score) and the Horibe GI bleeding prediction score (HARBINGER), to clinical practice was investigated. Using scores that are easy to calculate and memorable when used in the emergency department enables a more efficient use of medical resources. In addition, it may contribute to solving the problems regarding determining the need for intensive care in patients with upper GI bleeding. Methods: This study was conducted retrospectively on patients over the age of 18 who were admitted to the emergency department between September 1, 2018 and August 31, 2019. The HARBINGER and ABC scores and the Glasgow Blatchford score (GBS) were calculated for each patient. Following that, the need for intensive care, mortality, re-bleeding rate, and transfusion need were compared. Results: This study included 184 patients. When predicting the need for intensive care, the ABC score had a higher AUC value than the GBS and HARBINGER score, even when there was a low cut-off value (cut-off value >4). (AUC =0.944, specificity =0.74, sensitivity =0.83). Conclusion: This study found that the ABC score could be used to predict the need for intensive care in upper GI bleeding, and that it outperformed other scores. Additionally, we concluded that the HARBINGER score, which had a “shock index” among its parameters, was not effective in predicting in-hospital adverse events
  • PublicationOpen Access
    Ivermectin Induces Oxidative Stress and DNA Damage in Breast Cancer Cells
    (2023-01-01) Güler E. M.; Günaydın Akyıldız A.; GÜNAYDIN AKYILDIZ, AYŞENUR
    Objective: Breast cancer (BC) remains to be one of the most diagnosed cancer types among women around the world. Drug repurposing is suggested to be a convenient alternative for drug development in cancer treatment. Ivermectin, the antiparasitic agent produced by the bacterium Streptomyces avermitilis, is currently being examined thoroughly in oncology and has begun to be seen as a potential drug candidate for BC therapy. However, studies are limited, and the exact anti-tumorigenic mechanism is not yet clarified in breast cancer. Methods: For elucidating the molecular mechanisms of Ivermectin’s potential anticancer effects, we have examined its in vitro effects on BC cells in terms of cell viability, intracellular ROS levels, glutathione levels, mitochondrial membrane potential, apoptosis, and DNA damage. Results: Ivermectin induces apoptosis via oxidative stress and DNA damage in BC cells. Conclusion: The in vitro mechanistic studies of promising anticancer agents for repurposing are essential guides for drug developers. For this purpose, ivermectin should be further studied as a drug candidate for its potential in the treatment of breast cancer.
  • PublicationOpen Access
    EDITORIAL
    (2022-04-01) Akçakaya A.; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Editorial
    (2022-04-01) Akçakaya A.; AKÇAKAYA, ADEM
  • PublicationOpen Access
    EDITORIAL
    (2022-04-01) Akçakaya A.; AKÇAKAYA, ADEM
  • PublicationOpen Access
    EDITORIAL
    (2021-09-01) Akçakaya A.; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Identification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study
    (2022-12-01) Bektay M. Y.; Sancar M.; Okyaltırık F.; Durdu B.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; OKYALTIRIK, FATMANUR; DURDU, BÜLENT; İZZETTİN, FIKRET VEHBI
    Objective: Clinical prognosis of coronavirus disease-19 (COVID-19) may be severe and unexpected. Patients may quickly progress to respiratory failure, infections, multiple organ dysfunction, and sepsis. The main objective of this study is to investigate the drug-related problems of patients with COVID-19 and related factors. Method: A prospective observational study was conducted on patients with COVID-19 between September 2020 and May 2021. Patients’ demographics, comorbid diseases, prescribed medicines and laboratory findings were recorded. Drug-related problems (DRPs) were identified by a clinical pharmacist according to recent guidelines, UpToDate® clinical decision support system and evidence-based medicine. Results: The median age of 107 patients was 64 and 50.46% of them were male. The median number of comorbidities was 3 (2-4) per patient. The majority of the patients had at least one comorbidity (88.79%) other than COVID-19 and the most frequent comorbidities were hypertension, diabetes mellitus and coronary artery disease. The total number of DRPs was recorded as 201 and at least one DRP was seen in 75 out of 107 patients. The median number of DRPs was 2 (0-8). In multivariate model, number of comorbidities (odss ratio (OR)=1.952; 95% confidence interval (CI)=1.07-3.54, p<0.05, number of medications (OR=1.344; 95% CI=1.12-1.61, p<0.001), and serum potassium levels (OR=5.252; 95% CI=1.57-17.56, p<0.001) were the factors related with DRP. Conclusion: This study highlights the DRPs and related factors in patients with COVID 19 in hospital settings. Considering unknown features of the infection and multiple medication use, DRPs are likely to occur. It would be beneficial to consider the related factors in order to reduce the number of the DRPs.
  • PublicationOpen Access
    Empathic Tendencies and Attitudes Toward People with Disabilities in Healthy Developing Children and Their Relationship Between Empathic Tendencies of Parents
    (2022-10-01) Sap R.; Özkan Ş.; Uğurlu Ü.; ÖZKAN, ŞÜHEDA; UĞURLU, ÜMIT
    Objective: This study was conducted to investigate empathic tendencies and attitudes toward people with disabilities in healthy developing children and the relationship between their parents’ empathic tendencies. Methods: Fifty-fourth grade primary school students and their parents were included in this study. KA-SI Empathic Tendency Scale-Child Form (KA-SI), Chedoke-Mcmaster Attitudes Towards Children with Handicaps Scale and Empathetic Tendency Scale (ETS) for parents were used. Results: When the total scores were considered, there was a moderate correlation between children's empathic tendencies and attitudes towards the disabled (r=0.594; p<0.0001). Any correlation was not observed among the empathic tendencies of parents and children’s empathic tendencies and attitudes towards the disabled (r=0.263 and r=0.270; p>0.05, respectively). Parents with a college degree had a higher level of empathy in their children (p<0.05). Conclusion: In this study, which examined the empathic tendencies of normally developed children and their attitudes towards the disabled and their relationship with the empathic tendencies of their parents, it was concluded that the increase in empathic tendencies of children supported their attitudes towards the disabled in a moderately positive way. The relationship between the level of education of parents and the increase in empathic tendencies of children may indicate the importance of education in this regard. Ensuring the development of children in terms of empathy and positive attitudes and improving the education levels of parents can support the participation of people with disabilities into life by supporting positive attitudes towards them.
  • PublicationOpen Access
    Comparison of Single and Double Incision Repair Techniques in Distal Biceps Tendon Rupture
    (2022-08-01T00:00:00Z) KAPICIOĞLU, Mehmet; Pulatkan, Anil; UÇAN, VAHDET; TEZGEL, OKAN; Bilsel, Kerem; KAPICIOĞLU, MEHMET; UÇAN, VAHDET; TEZGEL, OKAN; BİLSEL, İSMAIL KEREM
    Objective: The purpose of this study was to compare the complications and functional outcomes of single versus doubleincision repair techniques for the treatment of distal biceps brachii tendon rupture Methods: Between 2012 and 2018, patients with distal biceps brachii tendon rupture who were treated with a single or doubleincision repair technique were included in this retrospective study. Range of motion (ROM) and Mayo elbow performance scores (MEPS) were evaluated. Results: Seventeen patients with a mean age of 45.6±6.4 years (range: 34-58 years) who underwent single (n=9) and double (n=8) incision techniques were included in this study. The mean followup was 33±10.5 months (range: 24-62 months). Preoperative and postoperative ROM and MEPS were similar between two groups (p>0.05). In the single incision repair technique group, 3 patients had lateral antebrachial cutaneous nerve (LACN) palsy and 1 patient was re-operated due to re-rupture. In the double incision repair technique group, 1 patient had posterior interosseous nerve (PIN) palsy and 1 patient had hematoma that did not require surgical drainage. No significant differences were detected in terms of complications (p=0.62). Conclusion: Good functional results were obtained after both single and double incision techniques for the treatment of distal biceps brachii tendon rupture. Both single and double incision techniques were reliable however LACN was at risk in single incision technique and PIN in double incision technique.
  • PublicationOpen Access
    Surgeon's Neoadjuvan Therapy Approach in Gastric Cancer
    (2022-08-01T00:00:00Z) AKÇAKAYA, Adem; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Effect of Pilates Exercises on the Body Composition of Fasting Females
    (2022-08-01T00:00:00Z) Batar, Nazlı; Kermen, Seda; Sevdin, Sezen; Ersin, Aybüke; Güçlü, Duygu; GÜÇLÜ, DUYGU
    Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in Istanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.
  • PublicationOpen Access
    Safe Laparoscopic Cholecystectomy Techniques in Difficult Cases Comment
    (2022-06-01T00:00:00Z) AKÇAKAYA, Adem; AKÇAKAYA, ADEM
  • PublicationOpen Access
    The Role of Post-treatment FDG-PET/CT Scanning after the First-line Chemotherapy in Predicting Prognosis in Patients with Hodgkin Disease and High-grade Non-Hodgkin Lymphoma: A Comparative Study with Clinical Prognostic Risk Scoring Data
    (2022-06-01T00:00:00Z) ERDOĞAN, EZGİ BAŞAK; Guner, Sebnem; SÖNMEZOĞLU, KERİM; ERDOĞAN, EZGİ BAŞAK
    Objective: We aimed to evaluate the role of fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) performed after the first-line therapy in predicting prognosis of lymphomas and compare the results with the pretreatment prognostic risk scoring (PRS) indices. Methods: One hundred three patients with histopathologically confirmed Hodgkin (HD) and high-grade non-Hodgkin lymphoma (NHL) were included in the study. All patients received FDG-PET/CT imaging after the end of primary treatment. After intraveneus application of FDG, whole body PET/CT from the upper thigh to the vertex was performed. Results: The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of post-treatment FDG-PET/CT imaging in predicting remission status were 73.6%, 91.6%, 88%, 66.6%, and 94.0%, respectively. Those values were 63.0%, 62.0%, 62.0%, 27%, and 88.0% respectively, for pretreatment clinical risk scoring (p<0.001). Among the patients with positive PET scans after ending of the first-line therapy, 71.4% of those with only single lymph node station involvement stayed in remission, whereas 12.5% of the patients who had involvement of multiple lymph node stations and 16.7% of the patients who had extranodal disease could sustain in remission (p<0.05). Conclusion: We found that FDG-PET performed after first-line therapy was superior to clinical PRS systems in predicting prognosis of HD and NHL disease as conclusions. Although it was more successful to predict patients who would stay in remission with its high NPV, FDG-PET/CT imaging had a lower PPV due to false positive results. However, persistent FDG uptake in multinodal lymphatic stations and/or in extranodal sites on the post-therapy PET/CT scanning was more suggestive in predicting risk for recurrence.
  • PublicationOpen Access
    A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel
    (2022-06-01T00:00:00Z) Gokkaya, Bengisu; Atasoy, Sezen; ÇIRAKOĞLU, AYŞE; ARGÜDEN, YELDA; KURU, RAHİYE DİLHAN; YILMAZ, ŞÜKRİYE; ÖNGÖREN, ŞENİZ; DEVİREN, AYHAN; ATASOY, SEZEN
    Objective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study. Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenctic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
  • PublicationOpen Access
    Prevalence of Electrolyte Impairments Among Outpatient Elderly Subjects
    (2022-06-01T00:00:00Z) Heybeli, Cihan; Tan, Semen Gokce; KAZANCIOĞLU, Rümeyza; Smith, Lee; SOYSAL, PINAR; KAZANCIOĞLU, RÜMEYZA; SOYSAL, PINAR
    Objective: To determine the prevalence of different electrolyte imbalances in a cohort of elderly subjects aged ≥65 years, and evaluate associations between each electrolyte imbalance and functional dependence. Methods: We reviewed medical records of consecutive outpatient elderly subjects. Frequency of hyponatremia (serum sodium of 145 mmol/L), hypokalemia (serum potassium of 5.3 mEq/L), hypocalcemia (serum calcium of 10.5 g/dL), hypophosphatemia (serum phosphorus of 4.5 mg/ dL), hypomagnesemia (serum magnesium of 2.3 mg/dL) were assessed. Associations between each electrolyte disorder and Barthel and Lawton-Brody activities of daily living (BADL and IADL) were analyzed. Results: Among the 464 subjects, hyponatremia (11.2%) hypomagnesemia (9.1%) and hypermagnesemia (8.8%) were the most common disorders. Patients with one electrolyte imbalance constituted 30.2% (140 patients) of the cohort, while 44 (9.5%) had two, and 7 (1.5%) patients had ≥2 electrolyte imbalances, concurrently. Calcium, phosphorus, and magnesium disorders were more common among subjects who were 80 years of age or more, compared to those aged 65-79 years, while the frequency of potassium disorders was lower in the former group. Hyponatremia and hypocalcemia were associated with functional dependence based on BADL and IADL scores. Patients with multiple electrolyte abnormalities had a higher risk of functional dependence. Conclusion: Hypomagnesemia was as common as hyponatremia, especially among patients with an age of 80 years or more. Hyponatremia and hypocalcemia appeared to be associated with functional dependence. The higher number of electrolyte abnormality the higher risk of functional dependence. Our results should be confirmed by studies with larger sample sizes.
  • PublicationOpen Access
    The Validation and Reliability Study of Turkish Versions of Yale-Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder and Body Image Disturbance Questionnaire
    (2022-06-01T00:00:00Z) YÜCESOY, TÜRKER; ŞEKER, ELİF DİLARA; KARAKAŞ, MERT; ERTÜRK ZARARSIZ, GÖZDE; ŞAHBAZ, ÇİĞDEM DİLEK; ŞEKER, ELIF DILARA
    Objective: Body dysmorphic disorder (BDD) is a relatively common disorder and accepted as one of the obsessive-compulsive spectrum disorders group. No tests for BDD have been translated into Turkish yet. This study aimed to perform validity and reliability tests on the Turkish version of the Yale-Brown ObsessiveCompulsive scale Modified for BDD (T-YBOCS-BDD) and the Body Image Disturbance Questionnaire (T-BIDQ). Methods: The patients who were admitted to the clinics of the dentistry faculty with the aesthetic problems were selected as the study group (n=80) and the control group was designed with the patients with non-aesthetic problems (n=81). The tests were administered to the patients within one week with the test and re-test method. Factor analysis was performed, and the statistical significance was accepted as p<0.05 Results: In the evaluation of reliability, Cronbach’s alpha was 0.808 for the T-YBOCS-BDD and it was 0.780 for the T-BIDQ. The factor analysis scores were 0.705 and 0.736, whereas and the valuesof the Bartlett’s test of sphericity were 677,296 (df=66, p<0.001) and 336,069 (df=21, p<0.001), respectively. Total mean scores of T-YBOCS-BDD revealed statistically significant results (p=0.006). Conclusion: The tests resulted in high validity and reliability, therefore the results of this study highly recommended clinicians to perform these tests in the Turkish language-speaking countries.
  • PublicationOpen Access
    Screening of mecC Gene in Methicillin Resistant Staphylococcus aureus Isolates
    (2022-04-01T00:00:00Z) Ceylan, Ayse Nur; SÜMBÜL, BİLGE; DOYMAZ, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYA
    Objective: The diagnosis and treatment of mecC positive methicillin resistant Staphylococcus aureus (MRSA) isolates pose a significant problem in clinical microbiology and infectious disease practices. The studies on the frequency of mecC positive isolates in Turkey is rather scarce. In the present study, we aimed to investigate the presence of mecA, mecC, spa and pvu genes in MRSA strains isolated from various clinical specimens submitted to Clinical Microbiology Laboratories of Bezmialem Vakıf Hospital. Methods: We performed nucleic acid extraction and multiplex polymerase chain reaction (PCR) to 126 MRSA strains to detect mecC, mecA, spa and pvl genes. Results: According to the multiplex PCR results of 126 MRSA strains studied, 126 (100%) had mecA, 107 (85%) had spa, and 3 (2%) had pvl genes. We performed another polymerase chain reaction protocol and spa genes were identified in 19 of specimens, which were found negative priorly. Conclusion: Considering the factors that a university medical center where the study was conducted provided a tertiary healthcare service to a large metropolitan area in Istanbul and none of the isolates carried mecC gene might indicate that mecC gene carrying MRSA isolates did not pose a significant public health threat in Turkey.