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  • PublicationOpen Access
    Identification of Drug-Related Problems and Investigation of Related Factors in Patients with COVID-19: An Observational Study
    (2022-12-01) Bektay M. Y.; Sancar M.; Okyaltırık F.; Durdu B.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; OKYALTIRIK, FATMANUR; DURDU, BÜLENT; İZZETTİN, FIKRET VEHBI
    Objective: Clinical prognosis of coronavirus disease-19 (COVID-19) may be severe and unexpected. Patients may quickly progress to respiratory failure, infections, multiple organ dysfunction, and sepsis. The main objective of this study is to investigate the drug-related problems of patients with COVID-19 and related factors. Method: A prospective observational study was conducted on patients with COVID-19 between September 2020 and May 2021. Patients’ demographics, comorbid diseases, prescribed medicines and laboratory findings were recorded. Drug-related problems (DRPs) were identified by a clinical pharmacist according to recent guidelines, UpToDate® clinical decision support system and evidence-based medicine. Results: The median age of 107 patients was 64 and 50.46% of them were male. The median number of comorbidities was 3 (2-4) per patient. The majority of the patients had at least one comorbidity (88.79%) other than COVID-19 and the most frequent comorbidities were hypertension, diabetes mellitus and coronary artery disease. The total number of DRPs was recorded as 201 and at least one DRP was seen in 75 out of 107 patients. The median number of DRPs was 2 (0-8). In multivariate model, number of comorbidities (odss ratio (OR)=1.952; 95% confidence interval (CI)=1.07-3.54, p<0.05, number of medications (OR=1.344; 95% CI=1.12-1.61, p<0.001), and serum potassium levels (OR=5.252; 95% CI=1.57-17.56, p<0.001) were the factors related with DRP. Conclusion: This study highlights the DRPs and related factors in patients with COVID 19 in hospital settings. Considering unknown features of the infection and multiple medication use, DRPs are likely to occur. It would be beneficial to consider the related factors in order to reduce the number of the DRPs.
  • PublicationOpen Access
    Empathic Tendencies and Attitudes Toward People with Disabilities in Healthy Developing Children and Their Relationship Between Empathic Tendencies of Parents
    (2022-10-01) Sap R.; Özkan Ş.; Uğurlu Ü.; ÖZKAN, ŞÜHEDA; UĞURLU, ÜMIT
    Objective: This study was conducted to investigate empathic tendencies and attitudes toward people with disabilities in healthy developing children and the relationship between their parents’ empathic tendencies. Methods: Fifty-fourth grade primary school students and their parents were included in this study. KA-SI Empathic Tendency Scale-Child Form (KA-SI), Chedoke-Mcmaster Attitudes Towards Children with Handicaps Scale and Empathetic Tendency Scale (ETS) for parents were used. Results: When the total scores were considered, there was a moderate correlation between children's empathic tendencies and attitudes towards the disabled (r=0.594; p<0.0001). Any correlation was not observed among the empathic tendencies of parents and children’s empathic tendencies and attitudes towards the disabled (r=0.263 and r=0.270; p>0.05, respectively). Parents with a college degree had a higher level of empathy in their children (p<0.05). Conclusion: In this study, which examined the empathic tendencies of normally developed children and their attitudes towards the disabled and their relationship with the empathic tendencies of their parents, it was concluded that the increase in empathic tendencies of children supported their attitudes towards the disabled in a moderately positive way. The relationship between the level of education of parents and the increase in empathic tendencies of children may indicate the importance of education in this regard. Ensuring the development of children in terms of empathy and positive attitudes and improving the education levels of parents can support the participation of people with disabilities into life by supporting positive attitudes towards them.
  • PublicationMetadata only
    Evaluation of the physical and emotional effects of the COVID-19 pandemic on patients with fibromyalgia and chronic low back pain: A multicenter cross-sectional controlled study
    (2022-09-01) Bagcier, Fatih; Kibar, Sibel; Evcik, Deniz; Ketenci, Ayşegül; Sindel, Dilşad; Tur, Birkan Sonel; Ünlü, Zeliha; Tıkız, Canan; Keskin, Dilek; Alp, Alev; Ay, Saime; Yanık, Burcu; Geler Külcü, Duygu; Karakaş, Merve; Ural Nazlıkul, Fatma Gülçin; Kurt Oktay, Kübra Neslihan; Kasapoğlu Aksoy, Meliha; Fındıkoğlu, Gülin; Eser, Filiz; Atıcı, Arzu; Yurdakul, Ozan Volkan; Aybala Koçak, Fatmanur; Kurt, Emine Eda; Özkan, Yasemin; Koldaş Doğan, Şebnem; Erdem Sultanoğlu, Tuba; Ordahan, Banu; Karaca Umay, Ebru; Demirhan, Esma; Çağlar Yağcı, Hanife; Balbaloğlu, Özlem; Tezel, Nihal; Satış, Serap; Atar, Sevgi; Akaltun, Mazlum Serdar; YURDAKUL, OZAN VOLKAN
    Objectives: This study aimed to investigate the physical and emotional effects of the coronavirus disease 2019 pandemic in patients with fibromyalgia syndrome (FMS) and chronic low back pain (CLBP) patients. Patients and methods: The cross-sectional controlled study was performed with 1,360 participants (332 males, 1,028 females; mean age: 42.3±12.5 years; range, 18 to 65 years) between September 2020 and February 2021. The participants were evaluated in three groups: the FMS group (n=465), the CLBP group (n=455), and the healthy control group (n=440). Physical activity, pain levels, and general health status before and during the pandemic were evaluated in all participants. Stress levels were analyzed with the perceived stress scale (PSS) in all groups, and disease activity was analyzed with the fibromyalgia impact questionnaire (FIQ) in patients with FMS. Results: Patients with FMS had worsened general health status and pain levels during the pandemic compared to the other groups (p< 0.01). The FMS group showed significantly higher PSS scores than those in other groups (p< 01). There was a weak-positive correlation between FIQ and PSS parameters in patients with FMS (p< 0.05, r=0.385). Conclusion: The general health status, pain, and stress levels of the patients with FMS and CLBP tended to worsen during the pandemic. This high-stress level appeared to affect disease activity in patients with FMS.
  • PublicationMetadata only
    Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia
    (2022-07-01T00:00:00Z) EMİRALİOĞLU ORDUKAYA, NAGEHAN; HEKİMOĞLU, EMİNE RÜMEYSA; Kaya, Bengisu; Bilgic, Elif; ATİLLA, PERGİN; Gunaydin, Onder; Tugcu, Gokcen Dilsa; Polat, Sanem Eryilmaz; Hizal, Mina Gharibzadeh; Yalcin, Ebru; DOĞRU ERSÖZ, DENİZ; Kiper, Nural; Ozcelik, Ugur; HEKİMOĞLU, EMİNE RÜMEYSA
    Background: Cell culture increases both diagnostic specificity and sensitivity of primary ciliary dyskinesia (PCD) and the most important reason to use cell culture for definitive diagnosis in PCD is to exclude secondary ciliary defects. Here we aimed to evaluate the cilia functions and cilia ultrastructural abnormalities after ciliogenesis of cell culture in patients with definitive diagnosis of PCD. We also aimed to compare high speed videomicroscopy (HSVM) results of patients before and after ciliogenesis and to compare them with electron microscopy, genetic and immunofluorescence results in patients with positive diagnosis of PCD. Methods: This study was conducted as a cross-sectional study in patients with PCD. HSVM, transmission electron microscopy (TEM) and immunofluorescence staining results of the nasal biopsy samples taken from patients with the definitive diagnosis of PCD were evaluated and HSVM findings before and after cell culture were described. Results: Ciliogenesis and regrowth in the cell culture occurred in the nasal biopsy sample of eight patients with PCD. The mean age of the patients was 15.5±4.2 years (8.5-18 years). Mean beat frequency was found to be 7.54±1.01 hz (6.53-9.45 hz) before cell culture, and 7.36±0.86 hz (6.02-7.99 hz) after cell culture in the nasal biopsy of patients. There was no significant difference in the beat frequency of PCD patients before and after cell culture. Ciliary function analysis showed the similar beating pattern before and after cell culture in patients with PCD. Conclusions: This study showed us that there was no difference between cilia beat frequency and beat pattern before and after cell culture in patients with definitive diagnosis of PCD and repeated HSVM would be a useful diagnostic approach in patients who have no possibility to reach other diagnostic methods.
  • PublicationOpen Access
    Comparison of Single and Double Incision Repair Techniques in Distal Biceps Tendon Rupture
    Objective: The purpose of this study was to compare the complications and functional outcomes of single versus doubleincision repair techniques for the treatment of distal biceps brachii tendon rupture Methods: Between 2012 and 2018, patients with distal biceps brachii tendon rupture who were treated with a single or doubleincision repair technique were included in this retrospective study. Range of motion (ROM) and Mayo elbow performance scores (MEPS) were evaluated. Results: Seventeen patients with a mean age of 45.6±6.4 years (range: 34-58 years) who underwent single (n=9) and double (n=8) incision techniques were included in this study. The mean followup was 33±10.5 months (range: 24-62 months). Preoperative and postoperative ROM and MEPS were similar between two groups (p>0.05). In the single incision repair technique group, 3 patients had lateral antebrachial cutaneous nerve (LACN) palsy and 1 patient was re-operated due to re-rupture. In the double incision repair technique group, 1 patient had posterior interosseous nerve (PIN) palsy and 1 patient had hematoma that did not require surgical drainage. No significant differences were detected in terms of complications (p=0.62). Conclusion: Good functional results were obtained after both single and double incision techniques for the treatment of distal biceps brachii tendon rupture. Both single and double incision techniques were reliable however LACN was at risk in single incision technique and PIN in double incision technique.
  • PublicationMetadata only
    Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women
    Background: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.
  • PublicationOpen Access
    Surgeon's Neoadjuvan Therapy Approach in Gastric Cancer
    (2022-08-01T00:00:00Z) AKÇAKAYA, Adem; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Effect of Pilates Exercises on the Body Composition of Fasting Females
    (2022-08-01T00:00:00Z) Batar, Nazlı; Kermen, Seda; Sevdin, Sezen; Ersin, Aybüke; Güçlü, Duygu; GÜÇLÜ, DUYGU
    Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in Istanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.
  • PublicationOpen Access
    The Role of Post-treatment FDG-PET/CT Scanning after the First-line Chemotherapy in Predicting Prognosis in Patients with Hodgkin Disease and High-grade Non-Hodgkin Lymphoma: A Comparative Study with Clinical Prognostic Risk Scoring Data
    Objective: We aimed to evaluate the role of fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) performed after the first-line therapy in predicting prognosis of lymphomas and compare the results with the pretreatment prognostic risk scoring (PRS) indices. Methods: One hundred three patients with histopathologically confirmed Hodgkin (HD) and high-grade non-Hodgkin lymphoma (NHL) were included in the study. All patients received FDG-PET/CT imaging after the end of primary treatment. After intraveneus application of FDG, whole body PET/CT from the upper thigh to the vertex was performed. Results: The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of post-treatment FDG-PET/CT imaging in predicting remission status were 73.6%, 91.6%, 88%, 66.6%, and 94.0%, respectively. Those values were 63.0%, 62.0%, 62.0%, 27%, and 88.0% respectively, for pretreatment clinical risk scoring (p<0.001). Among the patients with positive PET scans after ending of the first-line therapy, 71.4% of those with only single lymph node station involvement stayed in remission, whereas 12.5% of the patients who had involvement of multiple lymph node stations and 16.7% of the patients who had extranodal disease could sustain in remission (p<0.05). Conclusion: We found that FDG-PET performed after first-line therapy was superior to clinical PRS systems in predicting prognosis of HD and NHL disease as conclusions. Although it was more successful to predict patients who would stay in remission with its high NPV, FDG-PET/CT imaging had a lower PPV due to false positive results. However, persistent FDG uptake in multinodal lymphatic stations and/or in extranodal sites on the post-therapy PET/CT scanning was more suggestive in predicting risk for recurrence.
  • PublicationMetadata only
    Effects of a Change in the Definition of Chronic Kidney Disease on Geriatric Assessment Parameters
    (2022-07-01T00:00:00Z) Heybeli, Cihan; SOYSAL, PINAR; Smith, Lee; Keskin, Elmas Biberci; KAZANCIOĞLU, Rümeyza; SOYSAL, PINAR; KAZANCIOĞLU, RÜMEYZA
    Objectives: Geriatric syndromes are common in elderly subjects with chronic kidney disease. An age-adapted definition of chronic kidney disease has recently been proposed. This study aimed to investigate the effects of this change in the definition of chronic kidney disease (from an estimated glomerular filtration rate of <60 to <45 mL/min/1.73 m(2)) on geriatric assessments. Methods: Records of an elderly outpatient population were retrospectively reviewed. Subjects underwent comprehensive geriatric assessment including the Basic and Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Score, Tinetti Mobility test, the Timed Up and Go test, the Mini Nutritional Assessment, the handgrip test, and the Insomnia Severity Index. Logistic regression analysis was performed in order to determine the odds ratio of each chronic kidney disease definition on geriatric syndromes. Results: Of the 1222 patients, 832 (68.1%) were women and the median age was 73 (interquartile range, 67-80) years. Patients with an estimated glomerular filtration rate of <45 and <60 mL/min/1.73 m(2) comprised 8.3% (n = 101) and 21.6% (n = 264) of the cohort, respectively. Both estimated glomerular filtration rates of <45 and <60 mL/min/1.73 m(2) were significantly associated with more unfavorable geriatric assessment scores in univariate analysis. After adjustments, associations of an estimated glomerular filtration rate <60 mL/min/1.73 m(2) with the Timed Up and Go test and polypharmacy remained significant; however, none of the geriatric assessment measures remained significantly associated with an estimated glomerular filtration rate of <45 mL/min/1.73 m(2). Conclusion: Chronic kidney disease was more significantly associated with impairments in geriatric assessment parameters when the cut-off of estimated glomerular filtration rate for the definition of chronic kidney disease was kept as <60 mL/min/1.73 m(2) in comparison to modification of <45 mL/min/1.73 m(2).
  • PublicationOpen Access
    A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel
    Objective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study. Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenctic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
  • PublicationOpen Access
    Prevalence of Electrolyte Impairments Among Outpatient Elderly Subjects
    (2022-06-01T00:00:00Z) Heybeli, Cihan; Tan, Semen Gokce; KAZANCIOĞLU, Rümeyza; Smith, Lee; SOYSAL, PINAR; KAZANCIOĞLU, RÜMEYZA; SOYSAL, PINAR
    Objective: To determine the prevalence of different electrolyte imbalances in a cohort of elderly subjects aged ≥65 years, and evaluate associations between each electrolyte imbalance and functional dependence. Methods: We reviewed medical records of consecutive outpatient elderly subjects. Frequency of hyponatremia (serum sodium of 145 mmol/L), hypokalemia (serum potassium of 5.3 mEq/L), hypocalcemia (serum calcium of 10.5 g/dL), hypophosphatemia (serum phosphorus of 4.5 mg/ dL), hypomagnesemia (serum magnesium of 2.3 mg/dL) were assessed. Associations between each electrolyte disorder and Barthel and Lawton-Brody activities of daily living (BADL and IADL) were analyzed. Results: Among the 464 subjects, hyponatremia (11.2%) hypomagnesemia (9.1%) and hypermagnesemia (8.8%) were the most common disorders. Patients with one electrolyte imbalance constituted 30.2% (140 patients) of the cohort, while 44 (9.5%) had two, and 7 (1.5%) patients had ≥2 electrolyte imbalances, concurrently. Calcium, phosphorus, and magnesium disorders were more common among subjects who were 80 years of age or more, compared to those aged 65-79 years, while the frequency of potassium disorders was lower in the former group. Hyponatremia and hypocalcemia were associated with functional dependence based on BADL and IADL scores. Patients with multiple electrolyte abnormalities had a higher risk of functional dependence. Conclusion: Hypomagnesemia was as common as hyponatremia, especially among patients with an age of 80 years or more. Hyponatremia and hypocalcemia appeared to be associated with functional dependence. The higher number of electrolyte abnormality the higher risk of functional dependence. Our results should be confirmed by studies with larger sample sizes.
  • PublicationOpen Access
    The Validation and Reliability Study of Turkish Versions of Yale-Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder and Body Image Disturbance Questionnaire
    Objective: Body dysmorphic disorder (BDD) is a relatively common disorder and accepted as one of the obsessive-compulsive spectrum disorders group. No tests for BDD have been translated into Turkish yet. This study aimed to perform validity and reliability tests on the Turkish version of the Yale-Brown ObsessiveCompulsive scale Modified for BDD (T-YBOCS-BDD) and the Body Image Disturbance Questionnaire (T-BIDQ). Methods: The patients who were admitted to the clinics of the dentistry faculty with the aesthetic problems were selected as the study group (n=80) and the control group was designed with the patients with non-aesthetic problems (n=81). The tests were administered to the patients within one week with the test and re-test method. Factor analysis was performed, and the statistical significance was accepted as p<0.05 Results: In the evaluation of reliability, Cronbach’s alpha was 0.808 for the T-YBOCS-BDD and it was 0.780 for the T-BIDQ. The factor analysis scores were 0.705 and 0.736, whereas and the valuesof the Bartlett’s test of sphericity were 677,296 (df=66, p<0.001) and 336,069 (df=21, p<0.001), respectively. Total mean scores of T-YBOCS-BDD revealed statistically significant results (p=0.006). Conclusion: The tests resulted in high validity and reliability, therefore the results of this study highly recommended clinicians to perform these tests in the Turkish language-speaking countries.
  • PublicationOpen Access
    Screening of mecC Gene in Methicillin Resistant Staphylococcus aureus Isolates
    (2022-04-01T00:00:00Z) Ceylan, Ayse Nur; SÜMBÜL, BİLGE; DOYMAZ, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYA
    Objective: The diagnosis and treatment of mecC positive methicillin resistant Staphylococcus aureus (MRSA) isolates pose a significant problem in clinical microbiology and infectious disease practices. The studies on the frequency of mecC positive isolates in Turkey is rather scarce. In the present study, we aimed to investigate the presence of mecA, mecC, spa and pvu genes in MRSA strains isolated from various clinical specimens submitted to Clinical Microbiology Laboratories of Bezmialem Vakıf Hospital. Methods: We performed nucleic acid extraction and multiplex polymerase chain reaction (PCR) to 126 MRSA strains to detect mecC, mecA, spa and pvl genes. Results: According to the multiplex PCR results of 126 MRSA strains studied, 126 (100%) had mecA, 107 (85%) had spa, and 3 (2%) had pvl genes. We performed another polymerase chain reaction protocol and spa genes were identified in 19 of specimens, which were found negative priorly. Conclusion: Considering the factors that a university medical center where the study was conducted provided a tertiary healthcare service to a large metropolitan area in Istanbul and none of the isolates carried mecC gene might indicate that mecC gene carrying MRSA isolates did not pose a significant public health threat in Turkey.
  • PublicationOpen Access
    Current Status of Approach to Thyroid Nodules
    (2022-04-01T00:00:00Z) AKÇAKAYA, Adem; AKÇAKAYA, ADEM
  • PublicationOpen Access
    Radiological Appearences of Benign Soft-tissue Tumors of the Hand and Wrist with Special Emphasis on NRI
    Tumoral and pseudotumoral lesions of the hand and wrist are commonly encountered in routine clinical practice. Although most of them arc benign, radiological differential diagnosis of these lesions is difficult, because of their nonspecific imaging findings, except ganglia, localized type of tenosynovial giant cell tumors and lipomas. Digital radiography, computed tomography, and ultrasound may be useful in identification of the lesions in the wrist and hand, but magnetic resonance imaging with superior contrast and spatial resolution is the most important imaging modality.
  • PublicationOpen Access
    Ischemic Stroke Severity, Stroke Types and Early Mortality in Patients with End-stage Renal Disease
    (2022-04-01T00:00:00Z) Ozkan, Sibel; USLU, Ferda; Yoldas, Tahir Kurtulus; USLU, FERDA
    Objective: To compare the demographic characteristics, vascular risk factors, stroke subtypes and early prognosis of patients with end-stage renal disease (ESRD)/normal renal function (NRF) with acute ischemic stroke (IS). Methods: Demographic data and vascular risk factors of patients with acute stroke between August 1 2013-April 1 2015 were determined. Patients diagnosed with ESRD who were receiving dialysis treatment with a glomerular filtration rate below 15, were included in the study. Stroke severity was determined by using the National Stroke Health Stroke scale. To determine the types of IS, “Trial of Org 10172 in Acute Stroke Treatment” TOAST criteria were used. Deaths during hospitalization were used to determine early mortality. Results: Of the 132 patients included in the study, 33.3% had ESRD and 66.6% had normal renal functions (NRF). Demographic characteristics and risk factors did not differ between ESRD and NRF groups. When stroke types were compared, it was determined that stroke with undetermined etiology with more than one etiology was higher in ESRD patients. Of all patients 10.6% died in hospital and this rate was 20.5% in ESRD patients. In the regression analysis, the presence of ESRD increased hospital mortality significantly (risk ratio: 11.6, 95% confidence interval 1.7-77, p=0.011). Conclusion: Our results showed that more than one etiology was seen in acute IS patients with ESRD and ESRD significantly increased the risk of hospital mortality.
  • PublicationOpen Access
    Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?
    (2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN
    Objective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.
  • PublicationOpen Access
    Statistical Errors in Medical Residency Theses
    (2022-04-01T00:00:00Z) Yabacı Tak, Ayşegül; Can, Fatma Ezgi; Kaşkır Kesin, Fisun; Ahmadian Tetik, Robab; Ercan, İlker; YABACI TAK, AYŞEGÜL
    Objective: The aim of this study is to evaluate the theses of residency in medicine in terms of statistical errors made and thus to contribute to the production of quality scientific publications by ensuring that scientific publishers in the Add of medicine are sensitive and careful about statistics when doing their work. Methods: In this study, we investigated 321 thesis theses which are defended from 6 different universities arc obtained from the database of the Turkish Higher Education Council. The investigation is was conducted in terms of "Errors Related to p-values", "Errors Related to Tests", "Mathematical Notation Errors", "Statistical Symbol Errors", "Inappropriate Interpretation", "Presentation of The the Statistical Method Analysis and Results in The the Incorrect Section of The the Manuscript", "Errors in Summarizing Data","Incomprehensible Statistical Terms" and "Errors in Statistical Terminology" Results: There was at least one statistical error in all 321 medicine residency theses examined. The most common error was "errors in summarizing data" with a ratio of 70.1% (n=225), while the least common error was "incomprehensible statistical expressions" with a ratio of 14.3% (n=46). Conclusion: As a result, both researchers and consultants who undertake scientific studies have a responsibility to minimize these errors. To prevent statistical errors, students who are doing residency in medicine arc required to receive the necessary training in statistical literacy, to have basic statistical knowledge, and to receive consultancy from a biostatistics expert for statistical evaluations. Students who residency in medicine in preventing statistical errors are required to receive the necessary training in statistical literacy, to have basic statistical knowledge, and to receive consultancy from a biostatistics expert for statistical evaluations.
  • PublicationOpen Access
    The Effect of Exogenous Human Albumin Administration on Acute Kidney Injury Development in Hypoalbuminemic Patients in the Intensive Care Unit
    (2022-04-01T00:00:00Z) Yeşiltaş, Serdar; Güzel, Cumali; Sümer, İsmail; Uysal, Harun; Daşkaya, Hayrettin; Türkay, Meltem; Karaaslan, Kazım; YEŞİLTAŞ, SERDAR; SÜMER, İSMAİL; UYSAL, HARUN; DAŞKAYA, HAYRETTİN; KARAASLAN, KAZıM
    Objective: Hypoalbuminemia is an independent risk factor for acute kidney injury (AKI) and mortality. The primary aim of our study was to investigate the effect of exogenous human albumin (EHA) administration on hypoalbuminemic patients in the intensive care unit (ICU) regarding the development of AKI. Our secondary aim was to compare the ICU admission duration and mortality rates of these patients. Methods: After receiving ethics committee approval, the researchers retrospectively screened database for 5,989 patients admitted to the adult ICU from 01.01.2014 to 01.06.2018. The demographic data, serum albumin and creatinine levels, ICU admission duration and mortality rates of patients were recorded. Stage 2-3 AKI was accepted based on the AKI network criteria, while hypoalbuminemia was accepted as serum albumin values below 3.5 g/dL. Patients not given EHA were assigned to group none human albumin (Group NHA), while patients given EHA were assigned to group human albumin (Group HA). The rate of AKI development, duration of stay in ICU and mortality rates were compared between the groups. Results: The mean age, AKI development rate, mortality rate and ICU admission duration in Group HA were statistically significantly higher than in Group NHA (p=0.0001, p=0.0001, p=0.0001, p=0.0001). There was no difference in terms of the gender distribution in the groups. The mean albumin value in Group HA was statistically significantly lower than Group NHA (p=0.0001). Conclusion: In conclusion, EHA administration in hypoalbuminemic patients prolong stay in ICU in addition to the increase in the development of AKI and mortality.