Person: TOPÇU, GÜLAÇTI
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Publication Stachys thirkei C. Koch Bitkisinin Antikolinesteraz Potansiyelinin Araştırılması(2017-04-29) Babalı, Fatmanur; DİNCEL, DEMET; TOPÇU, GÜLAÇTI; DİNCEL, DEMET; TOPÇU, GÜLAÇTIPublication Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine(2014-01-01T00:00:00Z) Bahadori, Fatemeh; Dag, Aydan; Durmaz, Hakan; Cakir, Nese; ONYUKSEL, Hayat; Tunca, Ümit; Topcu, Gulacti; Hızal, Gürkan; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTITwo amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.Publication Yeşil Alg Caulerpa cylindracea Sonder-den İzole Edilen Bis-İndol Alkaloidlerin SARS-CoV-2-ye Karşı in vitro Antiviral Aktivitesi(2022-06-23T00:00:00Z) Erol, Ebru; Avşar, Timuçin; Okudan, Emine Şükran; Topçu, Gülaçtı; EROL, EBRU; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTICaulerpaceae familyasına ait olanCaulerpa cylindraceaSonder yeşil bir deniz yosunudur. Gelibolu yarımadası kıyılarından SCUBA dalışlatoplananCaulerpacylindracea-nın builk kimyasal araştırması ile caulerpin1, mono metil caulerpinat2, beta-sitosterol ve palmitik asit izole edildi. İzole edilen bileşiklerin kimyasal yapıları, 1D- ve 2D-NMR ve kütle spektroskopik analizlerle aydınlatıldı. Caulerpin ve mono metil caulerpinatınin vitroanti-viral aktivitesi, Spike proteini ve main proteaza (3CL) karşı incelendi. Bu çalışmanın bulguları, caulerpin ve mono metil caulerpinatın Spike ve ACE2 etkileşimini önemli ölçüde inhibe ettiğini ortaya koymaktadır. Ayrıca, izole edilen bileşiklerin sitotoksik aktivitesi, sağlıklı fibroblast hücre hattı CCD-1079Sk ve iki meme kanseri hücre hattı; MDA-MB-231 ve MCF-7’ye karşı incelendi.Publication Oleanolik Asit Türevlerinin Sentezi ve Sitotoksik Aktivitelerinin Araştırılması(2017-04-02) TUNCAY, SALİH; ŞENOL, HALİL; GÜLER, ERAY METİN; ÖCAL, NÜKET; SEÇEN, HASAN; KOÇYİĞİT, ABDÜRRAHİM; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; TOPÇU, GÜLAÇTIPublication Fatty acid content of Reseda lutea var. lutea with antioxidant potential.(2015-06-12) Ertaş, Abdülselam; Boğa, Mehmet; DİNCEL, DEMET; BÜTÜN, BURCU; Yeşil, Yeter; Soruhan, H.F.; TOPÇU, GÜLAÇTI; KUŞMAN, TUBA; DİNCEL, DEMET; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIPublication A HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human UrineA HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human Urine(2013-08-16T00:00:00Z) Tekkeli, Şerife Evrim; Dincel, Demet; Önal, Armağan; Erkoç, Reha; Topçu, Gülaçtı; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMET; TOPÇU, GÜLAÇTIPublication Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada(2015-11-01) Butun, Burcu; Hatipoglu, Seda Damla; Dönmez, Ayşe; Topcu, Gülaçtı; BÜTÜN, BURCU; TOPÇU, GÜLAÇTIThe methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), beta-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (beta-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes. Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.Publication Special issue in Honour of Professor Ayhan Ulubelen(2011-12-01T00:00:00Z) TOPÇU, GÜLAÇTI; GÖREN, Nezhun; Öksüz, Sevil; TOPÇU, GÜLAÇTIPublication Special issue dedicated to the memory of Professor Ayhan Ulubelen (1931-2020)(2021-01-01T00:00:00Z) TOPÇU, GÜLAÇTI; TOPÇU, GÜLAÇTIPublication Investigation of Anti-Oxidant and Toxicological Effects Of Methanolic Extract of Rosmarinus officinalis(2015-10-17) BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES