Goal: 03 - Sağlık ve Kaliteli Yaşam
AMAÇ 3: SAĞLIKLI BİREYLER Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır. Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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- PublicationMetadata onlyRetrospective analysis of non-melanoma skin cancer in Kütahya Tavşanli region Kütahya Tavşanli Yöresi Melanom Dişi Deri Kanserlerinin Retrospektif Analizi(2015-01-01T00:00:00Z) Emiroʇlu, NAZAN; CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN
- PublicationMetadata onlyHBSAG SEROCOVERSION UNDER LAMIVUDINE IN HBEAG-NEGATIVE CHRONIC HEPATITIS B(2010-10-01T00:00:00Z) Seven, GÜLSEREN; Idilman, Ramazan; Bozkus, Yusuf; Cinar, Kubilay; Kabacam, Gokhan; Yakut, Mustafa; Bozdayi, A. Mithat; Yurdaydin, Cihan; SEVEN, GÜLSEREN
- PublicationMetadata onlyPrediction of mortality at first admission in COVID-19 pneumonia: A retrospective cohort study(2022-01-01T00:00:00Z) Koker, Ibrahi; Yurtsever, İsmail; Uysal, Omer; Huseynov, Nurlan; Senturk, Hakan; YURTSEVER, İSMAİL
- PublicationMetadata onlyCOVID-19 Pandemisi Sürecinde Fiziksel Tıp ve Rehabilitasyon Uzmanlarının Tutum, Görüşleri ve Anksiyete Düzeyleri(2021-02-13T00:00:00Z) BAĞCIER, FATİH; YURDAKUL, OZAN VOLKAN; YURDAKUL, OZAN VOLKAN
- PublicationMetadata onlyNasogastric Tube Feeding in Children with Cancer as a Part of Palliative Care(2017-05-20) BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; Erceylan, Memet Ali; KIZILTAN, HURİYE ŞENAY; AKÇAKAYA, ADEM; BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; KIZILTAN, HURİYE ŞENAY; AKÇAKAYA, ADEM
- PublicationMetadata onlyMetastatik prostat kanserinde nobiletin ve sorafenib kombin uygulamasının EMT üzerindeki etkisi(2019-11-01T00:00:00Z) Bilir, Cemil; Güney, Gamze; Özman, Zeynep; ÖZMAN, ZEYNEP
- PublicationMetadata onlyEffects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats(2019-03-01) Gökalp Özkorkmaz, Ebru; Özay, Yusuf; Pehlivanoğlu, Burçin; Yıldız, Atilla; Güzel, Sevda; Erdoğdu, İbrahim Halil; Darcan, Sinan; KUMAŞ, MELTEMThe genus Verbascum, commonly known as mullein, traditionally used in folk medicine, is known for its anti-inflammatory, antioxidant and antibacterial activities. Verbascum inulifolium Hub.-Mor. (Scrophulariaceae), is an endemic species from Turkey. Here, we examined the healing effect of methanol extract of the aerial parts of V. inulifolium on incisional and excisional skin wounds in diabetic and non-diabetic rats. Ointments of the extract were prepared in two concentrations (0.5 and 1% (w/w)) and applied topically on wound models once daily throughout for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatments, animals were sacrificed and measurements of hydroxyproline level and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, the granulation tissue thickness, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that the ethanolic extract of the aerial parts of V. inulifolium enhances the healing process of skin tissue in both non-diabetic and diabetic wounds. The best wound healing activity was observed in incisional wound treated with 0.5% (w/w) concentrated ointment (99.7%) and in excisional wound treated with 1% (w/w) concentrated ointment (98.1%) on day 14 according to macroscopic results.
- PublicationOpen AccessCarbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment(2020-10-01T00:00:00Z) Angeli, Andrea; Carta, Fabrizio; Nocentini, Alessio; Winum, Jean-Yves; Zalubovskis, Raivis; AKDEMİR, ATİLLA; Onnis, Valentina; Eldehna, Wagdy M.; Capasso, Clemente; De Simone, Giuseppina; Monti, Simona Maria; Carradori, Simone; Donald, William A.; Dedhar, Shoukat; Supuran, Claudiu T.; AKDEMİR, ATİLLAThe tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of anticancer therapies. The biochemical rationale behind many of these phenomena resides in the activation of transcription factors such as hypoxia-inducible factor 1 and 2 (HIF-1/2). In turn, the HIF pathway activates a number of genes including those involved in glucose metabolism, angiogenesis, and pH regulation. Several carbonic anhydrase (CA, EC 22.214.171.124) isoforms, such as CA IX and XII, actively participate in these processes and were validated as antitumor/antimetastatic drug targets. Here, we review the field of CA inhibitors (CAIs), which selectively inhibit the cancer-associated CA isoforms. Particular focus was on the identification of lead compounds and various inhibitor classes, and the measurement of CA inhibitory on-/off-target effects. In addition, the preclinical data that resulted in the identification of SLC-0111, a sulfonamide in Phase Ib/II clinical trials for the treatment of hypoxic, advanced solid tumors, are detailed.
- PublicationOpen AccessSelective in-vitro Enzymes- Inhibitory Activities of Fingerprints Compounds of Salvia Species and Molecular Docking Simulations(2020-01-01T00:00:00Z) ÖZHAN KOCAKAYA, ŞAFAK; ERTAŞ, ABDULSELAM; Yener, Ismail; Ercan, Bahadir; VARHAN ORAL, ELİF; Akdeniz, Mehmet; Kaplaner, Erhan; TOPÇU, GÜLAÇTI; Kolak, Ufuk; TOPÇU, GÜLAÇTIRecently Nutrition and Food Chemistry researches have been focused on plants and their products or their secondary metabolites having anti-alzheimer, anti-cancer, anti-aging, and antioxidant properties. Among these plants Salvia L. (Lamiaceae) species come into prominence with their booster effects due to high antioxidant contents, which have over 900 species in the world and 98 in Turkey. Some Salvia species are already in use as herbal treatment of vessel stiffness, Dementia like problems and cancer. Recently some species of Salvia are of extensive research topic. In this study, inhibitory potentials of secondary metabolites, rosmarinic acid, salvigenin, salvianolic acid A and B, tanshinone I and IIA, cyrtotanshinone, dihydrotanshinone I, carnosic acid, carnosol, and danshensu sodium salt were investigated against acetylcholinesterase, butyrylcholinesterase, urease and tyrosinase enzymes both in-vitro and in slico in detail. Elevated inhibitory effects on acetyl-and butyryl-cholinesterase of dihydrotanshinone I (IC50: 1.50 +/- 0.02 and 0.50 +/- 0.01 mu g/mL, respectively), carnasol (IC50: 11.15 +/- 0.05 ve 3.92 +/- 0.03 mu g/mL) and carnosic acid (IC50: 31.83 +/- 0.65 ve 4.12 +/- 0.04 mu g/mL) were observed. Furthermore, all other secondary metabolites were active against butyrylcholinesterase. Anti-urease (42.41 +/- 0.85%) and anti-tyrosinase (39.82 +/- 1.16%) activities of tanshinone I were also observed. Potential inhibitory effects of these molecules on target proteins were investigated using DOCK and molecular dynamics calculations. Dock score analysis and Lipinski parameters were demonstrated that these ligands are potential inhibitors against relevant enzymes. Our findings suggest that Salvia species can be utilized as a ptential source of anti-alzheimer active compounds for designing novel products.
- PublicationMetadata onlyOne step versus two step approach for gestational diabetes screening: systematic review and meta-analysis of the randomized trials.(2019-05-01T00:00:00Z) SACCONE, G; CAISSUTTI, C; KHALIFEH, A; MELTZER, S; SCIFRES, C; SIMHAN, HN; KELEKCI, S; Sevket, OSMAN; BERGHELLA, V; ŞEVKET, OSMAN