Publication:
The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report

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Date
2020-07-01T00:00:00Z
Authors
Kelahmetoğlu, Osman
Tok, Enis Olgu
Özer, Ömer Faruk
Yeniocak, Ali
Yağmur, Çağlayan
Eşrefoğlu, Mukaddes
Koçyiğit, Abdürrahim
Yıldız, Kemalettin
Güneren, Ethem
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Abstract
Objective: Vitamin D is a vitamin that has gained popularity in recent years and has an anti-inflammatory and immunmodular effect. In the literature review we conducted, there was no study investigating the effect of vitamin D to prevent ischemia reperfusion (I/R) injury in skeletal muscle. The aim of this study was to investigate the effect of vitamin D on skeletal muscle in I/R injury. Methods: Six rats were used in each group including ischemia group (group I) and experimental group (group D given vitamin D). In the histopathological examination, inflammation and apoptosis levels were studied in gastrocnemius muscle. In biochemical analysis, total oxidative stress and total antioxidant and catalase levels were evaluated in anterior tibialis muscle. Results: The number of apoptotic cells in group D were found significantly lower than group I. In the terms of total antioxidants and catalase levels, there were significant difference between group D and group I. Conclusion: Our results support the hypothesis that vitamin D is an agent that can be used to prevent I/R injury.
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Vitamin D, ischemia-reperfusion injury, skeletal muscle
Citation
Kelahmetoğlu O., Tok E. O. , Özer Ö. F. , Yeniocak A., Yağmur Ç., Eşrefoğlu M., Koçyiğit A., Yıldız K., Güneren E., -The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report-, Bezmiâlem Science, cilt.8, ss.233-237, 2020
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