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Publication Metadata only Presence of Auditory Pathway Abnormalities in Children With Neurofibromatosis Type 1 With Brainstem Focal Areas of Abnormal Signal Intensity: Diffusion Tensor Imaging Features(2024-06-10) Cesme D. H.; Atasoy B.; Alkan G.; Peker A. A.; Yilmaz T. F.; Yurtsever I.; Iscan A.; Alkan A.; ÇEŞME, DİLEK HACER; ATASOY, BAHAR; PEKER, ABDUSSELİM ADİL; YILMAZ, TEMEL FATİH; YURTSEVER, İSMAİL; İŞCAN, AKIN; ALKAN, ALPAYBackground: To investigate whether there is a difference in mean diffusivity (MD) and fractional anisotropy (FA) values in the auditory pathways of neurofibromatosis type 1 patients with and without focal areas of abnormal signal intensity (FASI) compared to healthy controls by using diffusion tensor imaging (DTI). Methods: Patients were classified as group 1 with focal areas of abnormal signal intensity in the brainstem, group 2 without focal areas of abnormal signal intensity, and healthy control group 3 according to the MRI findings. Mean diffusivity and fractional anisotropy values of lateral lemniscus, inferior colliculus, corpus geniculatum mediale, Heschl gyrus, and brainstem were compared between groups. The correlation between mean diffusivity and fractional anisotropy values of auditory pathways and age was investigated. Results: There was a significant difference between group 1 and group 2 in terms of mean diffusivity and fractional anisotropy values at lateral lemniscus, inferior colliculus, corpus geniculatum mediale, and Heschl gyrus. Increased mean diffusivity and decreased fractional anisotropy values at brainstem were found in group 1. There was a significant difference between group 1 and group 3 in terms of mean diffusivity values at all auditory pathways. Fractional anisotropy values obtained from lateral lemniscus, inferior colliculus, and Heschl gyrus decreased in group 1 compared with group 3. There was a negative correlation between mean diffusivity values and positive correlation between fractional anisotropy values at lateral lemniscus, inferior colliculus, Heschl gyrus, and age. Conclusions: Our diffusion tensor imaging findings show that the neuronal integrity of the auditory pathways is affected in neurofibromatosis type 1 patients with brainstem focal areas of abnormal signal intensity. We think that the disappearance of brainstem focal areas of abnormal signal intensity associated with myelin repair and the regression of diffusion tensor imaging changes in the auditory pathways occur simultaneously with advancing age in patients with neurofibromatosis type 1.Publication Metadata only Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients(2024-07-01) ERDOĞAN E. B.; TEKÇE E.; KOCA S.; Aslan N.; TOLUK Ö.; AYDIN M.; ERDOĞAN, EZGİ BAŞAK; TEKÇE, ERTUĞRUL; KOCA, SERHAT; TOLUK, ÖZLEM; AYDIN, MEHMETObjectiveTo investigate the relationship between intraprostatic Ga-68-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body( 68)Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in Ga-68-PSMA PET/CT imaging. MethodsEighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored. ResultsSUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value. ConclusionAlthough intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients. Nucl Med Commun 45: 629-641Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved.Publication Metadata only Association between self-reported visual symptoms (suggesting cataract) and self-reported fall-related injury among adults aged ≥ 65 years from five low- and middle-income countries.(2024-06-15) Smith L.; López Sánchez G. F.; Veronese N.; Soysal P.; Tully M. A.; Gorely T.; Allen P. M.; Rahmati M.; Yon D. K.; Ball G.; et al.; SOYSAL, PINARBACKGROUND: Cataracts may increase risk for falls but studies on this topic from low- and middle-income countries (LMICs) are scarce. Therefore, we examined the cross-sectional association between self-reported visual symptoms (suggesting cataract) and self-reported injurious falls in nationally representative samples of adults aged >= 65 years from five LMICs (China, Ghana, India, Mexico, and Russia). METHODS: Data from the WHO Study on global AGEing and adult health (SAGE) were analysed. Self-reported information on past 12-month fall-related injury and cataract based on symptoms were collected. Multivariable logistic regression and meta-analyses were conducted to assess associations. RESULTS: Data on 13,101 people aged >= 65 years were analysed [mean (SD) age 72.5 (11.3) years; 45.2% males]. The overall prevalence of self-reported fall-related injury and visual symptoms (suggesting cataract) were 4.9% and 29.4%, respectively. There was a positive association between self-reported visual symptoms (suggesting cataract) and fall-related injury (i.e., OR > 1) in all five countries but statistical significance was reached in three: China (OR = 1.60; 95% CI = 1.08-2.35), India (OR = 1.96; 95% CI = 1.15-3.35), and Russia (OR = 3.58; 95% CI = 2.06-6.24). The pooled OR including all five countries based on a meta-analysis was OR = 1.88 (95% CI = 1.32-2.68). CONCLUSIONS: Self-reported visual symptoms (suggesting cataract) were associated with higher odds for self-reported injurious falls among older adults in LMICs. Expanding availability of cataract surgery in LMICs may also have the additional benefit of reducing falls among older people.Publication Metadata only AGE EFFECT ON TYMPANOMETRIC EVALUATION RESULTS(2024-05-01) Gedik Toker Ö.; Kuru E.; Özbay B.; Akbıyık A. R.; Aksakal E. İ.; Bal N.; GEDİK, ÖZGEPublication Metadata only Heparin Enjeksiyonu Uygulamasına Yönelik YouTube™ Videolarının Bilgi, Güvenilirlik ve Kalite Analizi(2024-04-01) Demircan B.; Kiyak Y.; Kaya H.; DEMİRCAN, BURCU; KIYAK, YASEMINAmaç: YouTube hastalar ve sağlık profesyonelleri tarafından bilgiye erişim sitesi olmakla birlikte sağlık okuryazarlığı için eğitim aracı rolü gören bir video paylaşım sitesidir. Araştırma, YouTube video platformunda yer alan heparin enjeksiyonu uygulamasına yönelik videoların bilgi içeriği, kalite ve güvenilirliğini belirlemek amacıyla tanımlayıcı tipte gerçekleştirildi. Yöntemler: YouTube’da 01.02.2024 tarihinde \"deri altına enjeksiyon, \"heparin enjeksiyonu\" ve \"kan sulandırıcı iğne\" anahtar kelimeleri ile yapılan arama sonucunda ulaşılan 31 Türkçe video bağımsız iki gözlemci tarafından Faydalılık, Tüketici Sağlığı Kalite Kriterleri (DISCERN), Küresel Kalite Skalası (GQS), video süresi, görüntüleme sayısı, beğeni sayısı, yorum sayısı, YouTube’daki süresi açısından analiz edildi. Bulgular: Videoların %80,6’sının faydalı, %58,1’inin orta kalitede, %38,7’sinin orta derecede eğitim bilgisine sahip olduğu görüldü. Hemşireler tarafından yüklenen videoların USEFULNESS puanlarının hekimler ve bireysel olarak yüklenen videolara göre (P=,048), Sağlık kuruluşları ve hemşireler tarafından yüklenen videoların sırasıyla DISCERN (P=,025; P=,030) ve GQS puanlarının (P=,035; P=,005) bireysel olarak yüklenen videolara göre anlamlı derecede yüksek olduğu sonucuna ulaşıldı. Video süresi ile DISCERN (r=,499; P=,004), görüntüleme sayısı ile USEFULNESS (r=,370; P=,040) ve GQS (r=,499; P=,004), beğeni sayısı ile GQS (r=,483; P=,006) arasında pozitif yönde orta düzeyde bir ilişki bulundu. Sonuç: YouTube’da yer alan heparin enjeksiyonu videolarının orta kalitede olduğu ve hemşireler tarafından yüklenen videoların daha faydalı olduğu bulundu. Anahtar Kelimeler: Heparin enjeksiyonu, kan sulandırıcı iğne, sosyal medya, subkutan heparin enjeksiyonu, YouTube.Publication Metadata only Olive Leaf Extract Downregulates the Protein Expression of Key SARS-CoV-2 Entry Enzyme ACE-2, TMPRSS2, and Furin.(2024-06-04) Kocyigit A.; Kanimdan E.; Yenigun V. B.; Ozman Z.; Balıbey F. B.; Durmuş E.; Yasar O.; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Evaluating the accuracy and readability of ChatGPT in providing parental guidance for adenoidectomy, tonsillectomy, and ventilation tube insertion surgery(2024-06-01) POLAT E.; Polat Y. B.; ŞENTÜRK E.; DOĞAN R.; YENİGÜN A.; Tugrul S.; EREN S. B.; AKSOY F.; ÖZTURAN O.; POLAT, EMRE; ŞENTÜRK, EROL; DOĞAN, REMZI; YENİGÜN, ALPER; TUĞRUL, SELAHATTİN; EREN, SABRİ BAKİ; AKSOY, FADLULLAH; ÖZTURAN, ORHANObjectives: This study examined the potential of ChatGPT as an accurate and readable source of information for parents seeking guidance on adenoidectomy, tonsillectomy, and ventilation tube insertion surgeries (ATVtis). Methods: ChatGPT was tasked with identifying the top 15 most frequently asked questions by parents on internet search engines for each of the three specific surgical procedures. We removed repeated questions from the initial set of 45. Subsequently, we asked ChatGPT to generate answers to the remaining 33 questions. Seven highly experienced otolaryngologists individually assessed the accuracy of the responses using a four-level grading scale, from completely incorrect to comprehensive. The readability of responses was determined using the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL) scores. The questions were categorized into four groups: Diagnosis and Preparation Process, Surgical Information, Risks and Complications, and Postoperative Process. Responses were then compared based on accuracy grade, FRE, and FKGL scores. Results: Seven evaluators each assessed 33 AI-generated responses, providing a total of 231 evaluations. Among the evaluated responses, 167 (72.3 %) were classified as ‘comprehensive.’ Sixty-two responses (26.8 %) were categorized as ‘correct but inadequate,’ and two responses (0.9 %) were assessed as ‘some correct, some incorrect.’ None of the responses were adjudged ‘completely incorrect’ by any assessors. The average FRE and FGKL scores were 57.15(±10.73) and 9.95(±1.91), respectively. Upon analyzing the responses from ChatGPT, 3 (9.1 %) were at or below the sixth-grade reading level recommended by the American Medical Association (AMA). No significant differences were found between the groups regarding readability and accuracy scores (p > 0.05). Conclusions: ChatGPT can provide accurate answers to questions on various topics related to ATVtis. However, ChatGPT\"s answers may be too complex for some readers, as they are generally written at a high school level. This is above the sixth-grade reading level recommended for patient information by the AMA. According to our study, more than three-quarters of the AI-generated responses were at or above the 10th-grade reading level, raising concerns about the ChatGPT text\"s readability.Publication Metadata only Synthesis of pyrrole-heterocyclic derivatives as anti-Alzheimer and antidiabetic candidates: An in vitro-in silico study(2024-06-01) Petrova O. V.; Tomilin D. N.; Şenol H.; Belyaeva K. V.; Nikitina L. P.; Oparina L. A.; Sobenina L. N.; Trofimov B. A.; Sadeghian N.; Taslimi P.; et al.; ŞENOL, HALILPublication Metadata only Enamel Matrix Derivative, 58S5 Bioactive Glass, and Fluoride Varnish for Enamel Remineralization: A Multi-analysis Approach(2024-05-01) Gungor A. S.; DALKILIÇ E.; ALKAN E.; Yılmaz-Atalı P.; TAĞTEKİN D.; DALKILIÇ, EVRIMPURPOSE: This study aimed to evaluate the enamel remineralization efficacy of enamel matrix derivative (EMD), experimental bioactive glass (BAG), and fluoride varnish in vitro. METHODS AND MATERIALS: Artificial initial caries lesions were developed on fifty human enamel specimens using demineralization solution (pH 4.5, 37°C, 96 hours). Specimens were randomly assigned to five groups (n=10): I-5% NaF varnish (Enamelast), II-experimental 58S5 BAG+37% phosphoric acid (PA), III-EMD (Emdogain) + Ethylenediaminetetraacetic Acid (EDTA), IV-EMD+37% PA, V-Control (untreated). All remineralization agents were applied with pH cycling for seven days. The specimens were scanned by spectral domain optical coherence tomography (SD-OCT) at baseline, at demineralization, and after pH cycling. Lesion depths were measured using image analysis software (ImageJ). Lesions were evaluated using surface microhardness (SMH) and two fluorescence methods (FluoreCam and DIAGNOdent Pen [DDPen]). The data were statistically analyzed by Kruskal Wallis, Friedman, and Wilcoxon tests (α=0.05). RESULTS: According to SD-OCT results, fluoride varnish was found to be the most effective agent in reducing lesion depth (p=0.005). All agents increased the SMH values after pH cycling. No significant difference was found among fluoride varnish, BAG, and EMD+PA groups. These SMH values were significantly higher than EMD+EDTA and control groups (p<0.001). All groups showed lower DDPen scores compared with the control group (p<0.001), however, no significant difference was found among the remineralization agents. In FluoreCam assessment, size and intensity values of all treated groups showed improvement. However, there was no significant difference between the treatment groups in terms of FluoreCam size measurements (p=0.186). CONCLUSION: 58S5 BAG and EMD+PA have remineralization capacity as effective as fluoride varnish. EMD+PA showed better SMH and lesion intensity results than EMD+EDTA.Publication Metadata only Phytoactive essential oils-composed water-free organogels: Development, characterization and proof of antibacterial activity(2024-08-01) ALĞIN YAPAR E.; Gökçe E. H.; Şahiner A.; İNAL E.; ULUSOY Ş.; Souto E. B.; Akanoğlu B.; KARTAL M.; İNAL, EBRAR; ULUSOY, ŞEYMA; KARTAL, MURATThe objective of this study was to develop and analyze a gel-like formulation that does not contain water, made from natural compounds found in essential oils, which are known for their antimicrobial properties and ability to reduce inflammation. Lentisk tree (Pistacia lentiscus L.), yarrow (Achillea millefolium L.) and myrtle (Myrtus communis L.) grow in the mild climate of Eurasia and are receiving particular attention for their medicinal and aromatic value. Two distinct concentrations of selected essential oils (EOs) were tested, dispersed in organogels based on 3 % (m/V) Carbopol 974P NF in PEG 400. Prior to formulation development, selected EOs were characterized by mass spectroscopy to identify the dominating bioactives. A total of 32 compounds were quantified for lentisk leaf EO, 42 for yarrow EO, and 26 for myrtle leaf EO. The best formulations were found for the highest concentration of EOs (4 %, m/m) into Carbopol/PEG400 organogels. Organogels were produced by high-speed homogenization followed by microwave heating and showed acceptable pH between 5.8 and 6.0, being compatible with the skin, with an electrical conductivity highest for yarrow EO-based organogel (YIG4%, ∼64 mV), and the lowest for myrtle EO-based organogel (MIG4%, ∼48 mV). Texture analysis showed the highest adhesion properties for lentisk EO-based organogel (LIG4%), attributed to its higher viscosity recorded for the two tested temperatures (25 °C vs 37 °C). Rheological analysis confirmed that organogels have pseudoplastic behaviour. The antibacterial activity was compared between plain EOs and EOs-based organogels, with the yarrow EO and its organogel (YIG4%) depicting the highest activity against both tested bacterial strains (S. aureus and C. acnes). On the other hand, MIG4% contributed for the highest cell proliferation rate tested in a mouse embryo fibroblast cell line (3T3-L1), whereas with LIG4% the lowest viability value was recorded.Publication Metadata only Characteristic features and prognostic factors in gastric cancer patients with bone metastases: multicenter experience(2024-05-21) HAMDARD J.; BİLİCİ A.; Sakin A.; Kahraman S.; YASİN A. İ.; KALACI E.; Gokmen I.; AÇIKGÖZ Ö.; KUTLU Y.; Sendur M. A. N.; et al.; YASİN, AYŞE İREM; ŞEKER, MESUTWe evaluated the incidence, clinicopathological features, prognostic factors, progression-free survival (PFS) and overall survival (OS) of patients with gastric cancer and bone metastases. The medical records of 110 patients with bone metastases were retrospectively analyzed. In our study, the incidence of bone metastases was 3.2%. The median patient age was 60 years. A total of 68 (61.8%) patients exhibited synchronous metastases, and 42 (38.2%) patients developed metachronous metastases. Alkaline phosphatase (ALP) levels were high in 54 (49%) patients. At the median follow-up time of 9.8 months, median PFS and OS times were 4.7 and 6.3 months, respectively. The median interval from the diagnosis to bone metastases was 9.3 months. Univariate analysis showed that Eastern Cooperative Oncology Group Performance Status (ECOG PS) >= 2, stage at diagnosis, time of metastases, number of metastases, presence of extraskeletal metastases, use of zoledronic acid treatment, palliative chemotherapy post-bone metastases and radiotherapy to bone metastases were significant prognostic indicators for PFS. Additionally, ECOG PS >= 2, stage at diagnosis, time of metastases, number of metastases, presence of extraskeletal metastases, zoledronic acid treatment, palliative chemotherapy post-bone metastases, and radiotherapy to bone metastases significantly influenced OS. Moreover, in multivariate analysis, ECOG PS, time of metastases, presence of extra-bone metastases, and the use of palliative chemotherapy after bone metastases were found to be independent prognostic factors for PFS. Moreover, ECOG PS, time of metastases, and use of palliative chemotherapy after bone metastases were significantly independent prognostic indicators for OS. Our findings show that the presence of synchronous metastases, use of palliative chemotherapy, use of zoledronic acid after bone metastases, and ALP level within the normal range were significantly associated with prolonged OS in gastric cancer patients with bone metastases.Publication Metadata only INVESTIGATION OF THE FACTORS QUIET QUITTING AND QUIET FIRING WITH THE STRUCTURAL EQUATION MODELLING: A PILOT RESEARCH ON HEALTH PROFESSIONAL’S(2024-06-06) Akbaş M.; Köse A. M.; AKBAŞ, MERVEINVESTIGATION OF THE FACTORS QUIET QUITTING AND QUIETFIRING WITH THE STRUCTURAL EQUATION MODELLING: APILOT RESEARCH ON HEALTH PROFESSIONAL’SMerve AKBAŞ1, Ali Mertcan KÖSE2,1 Bezmialem Vakif University, Department of Healthcare Management Istanbul, Türkiye and e-mail:makbas@bezmialem.edu.tr2Istanbul Ticaret University, Department of Computer Programming Istanbul, Türkiye and e-mail:amertcankose@ticaret.edu.trAbstractAfter the COVID-19 outbreak, there have been changes in the work culture, and new conceptshave emerged by moral injury and quiet quitting. Healthcare professionals can witnesspatients many emotions, such as pain, loneliness, and hopelessness. In the case of effects ofthe quality of care, that causes \"Moral Injury\" and \"Quiet Quitting\". \"Quiet Quitting\" meansnot leaving the job, not only taking on extra responsibilities but also continuing to work. Itconsists of two dimensions as \"Quiet Quitting\" and \"Quiet Firing\". Research shows thatappreciated employees give meaning to work and their commitment to the organizationincreases [1]. In this regard, \"Employee Resilience\" refers to the ability of employees to copewith the difficulties they encounter and improve themselves. It is important to provideefficient service in the constantly changing business environment. This study aims to evaluatethe mediating role of employee resilience in the effect of moral injury on quiet quitting and inlight of the findings, to propose different human resources (HR) management strategies in thehealth sector. In this research, the mediating role of employee resilience was examined in theeffect of moral injury on quiet quitting and quiet firing by using structural equationmodelling. The study collected data from 131 (age: 33.29 ± 9.60) participants working in thehealth profession through relevant scales. In this respect, the research has an empiricalcharacter. First, the essential characteristics of the participants who made the data set weredetermined using descriptive statistics. While moral injury had a positive effect on Quietquitting (β=0.648) and Quiet firing (β=0.366) (p < 0.0001), it was found to have a negativeeffect on Employee resilience (p < 0.0001; β= - 0.383). However, it was determined in themodel that employee resilience had a negative effect on quiet quitting (β= - 0.263) and quietfiring (β= - 0.289) (p < 0.0001). The indirect effects of employee resilience on the effect ofmoral injury on quiet quitting and quiet firing were found to be statistically significant (p <0.0001; β1=0.085, β2= 0.104). In this case, it was determined that employee resilience had amediating effect in the model. In addition, the structural equation model was supported by thefitted criteria (RMSEA=0.08, NFI=0.93, NNFI=0.96, CFI=0.97, GFI=0.96, AGFI=0.94). As aresult, while there is an increase in quiet quitting and quiet firing behaviours’ of healthcareprofessionals due to moral injury, employee resilience decreases this situation. Many studieshave concluded that 72% of Generation Y employees quietly leave their jobs [2]. In themeans of this research, improvements are expected to ensure the sustainability oforganizations and health systems.Key Words: Quiet Quitting, Moral Injury, Employee Resilience, Healthcare Professionals,Structural Equation Modelling.Publication Metadata only Genç Yetişkinlerde Dijital Oyun Bağımlılığının Sağlıklı Yaşam Parametreleri Üzerine Etkisi(2019-11-01) Tanrıverdi M.; Yekelenga S.; TANRIVERDİ, MÜBERRAPublication Metadata only HELAL BESLENME PERSPEKTİFİ: SAĞLIKLI VE SÜRDÜRÜLEBİLİR BİR YAŞAM YAKLAŞIMI(2024-05-20) Erkoç Z.; Yılmaz S. E.; YILMAZ, SOLMAZ ECEHelal beslenme, içeriğinde bulunan doğal ve organik bileşenlerle sağlığa olumlu yönde etki eder. Katkı maddelerinden arındırılmış, doğal üretim yöntemleriyle elde edilen helal gıdalar, vücudun ihtiyaç duyduğu besin maddelerini daha etkili bir şekilde sağlar. Bu durum, metabolizmanın düzenlenmesine, enerji seviyelerinin artmasına ve genel sağlık durumuna olumlu katkıda bulunur. Helal beslenme yalnızca bireyin sağlığı ile sınırlı olmayıp aynı zamanda gezegenimizin sürdürülebilirliğine de etki eder. Bu derlemenin amacı sürdürülebilir beslenmenin temel ilkelerinin değerlendirilmesi ve sürdürülebilirlik ile helal beslenme ilişkisinin araştırılmasıdır. Ayrıca, helal beslenmenin temel kavramları ele alınmış, sertifikasyon sürecinden sağlık üzerindeki etkilerine kadar çeşitli yönleri incelenmiştir. Besin teknolojilerinin helal beslenmeye uygunluğu da ele alınmıştır. Bu bağlamda, helal beslenme yalnızca kişisel ve dini bir tercih olmanın ötesinde, çevresel ve küresel sorumlulukların yerine getirildiği sürdürülebilir beslenme bakış açısında incelenmiştir. Anahtar Kelimeler: Helal Beslenme, Sertifikasyon, Sağlık, Sürdürülebilir Beslenme, Besin TeknolojisiPublication Metadata only Association between COVID-19 and subsequent depression diagnoses-A retrospective cohort study.(2024-06-08) Smith L.; Sánchez G. F. L.; Konrad M.; Veronese N.; Soysal P.; Koyanagi A.; Kaur N.; Kostev K.; SOYSAL, PINARPublication Metadata only Biallelic loss-of-function of a tRNA modification gene leads to impaired shoaling behavior and decreased startle response in zebrafish(2024-06-03) Süsgün S.; Quynh Nhu N.; Yücesan E.; Wellalage-Don D.; Kim T.; Choi T.; Uğur İşeri S. A.; Kim C.; SÜSGÜN, SEDAPublication Metadata only Detection of single nucleotide chamges in the MMP-1 gene EXON-1 region in individuals with atherosclerotic cardiovascular disease by sanger sequencing method(2024-06-08) Seçkin C. O.; Karaca M.; Yabacı Tak A.; Süner S.; YABACI TAK, AYŞEGÜLPublication Metadata only Stress distribution of four implant supported overdentures with tilted standard-sized implants and mini implants(2024-01-01) TURP I.; TURP V.; Tuncel İ.; Üşümez A.; TURP, IŞILPurpose The goal of the current study is to evaluate the stress distribution when tilted implants and mini-implants are used to support a mandibular overdenture. Materials and Methods Three-dimensional (3D) finite element models of mandibular overdentures were established using four, axial, standard-sized implants (SA model), four standard-sized implants with the mesial ones axial and the distal ones tilted (ST model) and four mini-implants (MA model) with Locator attachments. On each model, a 100 N load was applied to the overdenture in four different directions; bilateral vertical, unilateral vertical and oblique load on the posterior region, and a vertical load on the incisors. The stresses distributed at the peri-implant bone, implants, the prosthetic components, and the overdentures were evaluated. Results Non-axial posterior loading caused higher stress values in the implant and the prosthetic component than axial posterior loading. Lower stress values of the implant and the prosthetic component were observed in the ST model than SA model. The stress distribution in the overdenture at posterior loads were mostly observed around the implants. Conclusion Less prosthetic complications may be expected when the treatment option in the ST model is used. Fatigue fractures may occur around the implants in the overdentures, precautions are advised.Publication Metadata only Ortopedik ve Osteopatik Manuel Terapi Teknikleri(İstanbul Kitabevi, 2024-02-01) Safran E. (Editör); SAFRAN, ERTUĞRULPublication Metadata only Effect of layer thickness and polishing on wear resistance of additively manufactured occlusal splints(2024-07-01) Diken Türksayar A. A.; DİKER B.; DİKER, BURCUObjective: To evaluate the effect of polishing and layering thickness on the wear resistance of 3D-printed occlusal splint materials. Methods: Specimens with 3 different layer thicknesses (50, 75, 100 µm) were produced in the form of a disc 3 mm thick using V-Print splint resin on a 3D-printer with digital light processing technology. (n = 16 for each thickness) All specimens were washed and cured according to the manufacturer\"s instructions. Half of the specimens of each layer thickness were polished with silicon carbide papers. All specimens were subjected to 120.000 cycles of a chewing simulator for 2-body wear tests. Before and after the wear test, the specimens were scanned with a laser scanner, and the images were overlaid using a 3D analysis program and the volume loss was calculated. The wear patterns of the specimens were examined under a scanning electron microscope. Statistical evaluation was performed using a Shapiro-Wilk test, 2-way ANOVA, 1-way ANOVA, and Tukey post hoc test (α = 0.05). Results: While polishing had a significant effect (p = 0.003) on the wear volume of the occlusal splints, layer thickness (p = 0.105) and their interaction between polishing and layer thickness (p = 0.620) did not significantly affect the wear volume. Regardless of the polishing, the lowest mean wear was observed for D50 (0.064 mm3), followed by D75 (0.078 mm3), and D100 (0.096 mm3). However, a significant difference was observed only between polished D50 and unpolished D100. Conclusion: The polished 3D-printed occlusal splint resin showed higher wear resistance than the unpolished one, regardless of the layer thickness. Clinical significance: Since different layer thicknesses of 50 µm and greater had no effect on the wear resistance of the material, a layer thickness of 100 µm may be preferred for faster printing. However, polishing occlusal splints may reduce the amount of wear and improve clinical performance.