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    (2024-03-15) Alabaş E. D.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
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    (2024-03-15) Semiz D.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
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    The Reliability and Validity Study of the Turkish Version of Yale-Brown Obsessive-compulsive Scale Modified for Body Dysmorphic Disorder for Adolescents
    (2024-02-01) Şeker E. D.; Yılmaz S.; Kaya N.; Yücesoy T.; Ertürk G.; ŞEKER, ELIF DILARA; KAYA, NİHAL
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    HızlıMaksiler Ekspansiyon Protokolünde Farklı Tekniklerin Sonlu Elemanlar Analiziyle Karşılaştırılması
    (2022-11-17) Kaya N.; Şeker E. D.; Yücesoy T.; KAYA, NİHAL; ŞEKER, ELIF DILARA
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    Sarcopenia, but not malnutrition, is associated with fear of falling in older patients with dementia.
    (2024-01-31) Okudur S. K.; Smith L.; Tan S. G.; Yigitalp V.; Soysal P.; SOYSAL, PINAR
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    The role of intraoperative consultation in the management of ovarian masses and endometrial carcinomas: a 7-year experience
    (2024-02-01) Şahin N.; Coşanay Tekden B.; Çoban G.; Kıran G.; Arıcı D. S.; Toluk Ö.; Gücin Z.; ŞAHİN, NURHAN; COŞANAY TEKDEN, BÜŞRA; ÇOBAN, GANİME; KIRAN, GÜRKAN; TOLUK, ÖZLEM; GÜCİN, ZÜHAL
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    The effect of platelet-rich fibrin, platelet-rich plasma, and concentrated growth factor in the repair of full thickness rotator cuff tears
    (2024-01-01) Celikten M.; ŞAHİN H.; Senturk G. E.; Bilsel K.; Pulatkan A.; KAPICIOĞLU M.; ŞAKUL B. U.; BİLSEL, İSMAIL KEREM; KAPICIOĞLU, MEHMET
    Background: Rotator cuff lesions rank among the prevalent causes of shoulder pain. Combining surgical interventions with growth factors, scaffolds, and stem cell therapies can effectively decrease the likelihood of rotator cuff repair recurrence. Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF), isolated from blood and rich in growth factors, have a critical role in cell migration, cell proliferation, and angiogenesis during the tissue regeneration process. Investigations have further substantiated the beneficial impact of PRP and PRF on the biomechanical and histologic attributes of the tendon-bone interface. We aimed to investigate the effectiveness of CGF compared with PRF and PRP in the repair of rotator cuff lesions as a new treatment strategy. Methods: Incision was performed on both shoulder regions of 21 adult rabbits. After 8 weeks, both shoulders of the rabbits were repaired by suturing. PRF and CGF were administered to 2 separate groups along with the repair. Tissues were collected for biomechanical measurements and histologic evaluations. Results: Histologically, CGF, PRF, and PRP showed similar results to the healthy control group. The level of improvement was significant in the PRF and PRP groups. In the PRF group, the distribution of Ki67 (+), CD31 (+), and CD34 (+) cells was determined intensely in the tendon-bone junction regions. Apoptotic cells increased significantly in the repair group compared with the healthy group, whereas fewer apoptotic cells were found in the PRF-, PRP-, and CGF-applied groups. In the biomechanical results, no statistical difference was recorded among the groups. Conclusion: The use of PRF, PRP, and CGF in rotator cuff repair shows promise in shortening the treatment period and preventing the recurrence of rotator cuff lesions.
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    Determining the Frequency of Restless Legs Syndrome in the Adult Population
    (2024-10-01) KISKAÇ N.; ZORLU M.; ZORLU, MEHMET
    Objective: Restless legs syndrome (RLS) is a chronic disease that usually occurs in the legs, resulting in involuntary movement of the legs with uncomfortable sensations. RLS negatively affects the quality of life of individuals. In this study, it is aimed to increase awareness by determining the frequency of RLS in the adult population. Methods: The study was a descriptive and cross-sectional study. In the study, 565 individuals aged 18 and over participated. The data were collected online from individuals with the form of describing the personal characteristics of the individuals, the RLS Diagnostic Criteria Questionnaire, and the RLS Severity Rating Scale. IBM SPSS statistics 26.0 program was used in the analysis of the data. Results: In this study, the frequency of RLS was 17.5% and the severity score was 19.22 +/- 6.97 (moderate). The rate of admitting to a health institution due to the symptoms of individuals is 5.8%. In this study, the frequency of RLS was found to be significantly higher in those with diabetes, hypertension, age, and high body mass index. Conclusion: Although most of the participants in this study had symptoms of RLS, it was seen that they were not admitted to a health institution. If these individuals are not treated, their quality of life gets affected negatively, and this negatively affects the quality of health care. In order to increase the quality of health care, RLS should be screened especially in risky groups and treatment should be started in determined patients.
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    Phytotherapy in Obesity: Is It Necessary to Have Surgery?
    (2024-10-01) AKÇAKAYA A.; AKÇAKAYA, ADEM
    The prevalence of obesity, which is defined by the World Health Organization as abnormal or excessive fat accumulation in the body that impairs health, is increasing day by day. In addition to behavioral therapy aimed at changing the individual\"s lifestyle based on the strategies developed against the disease, diet therapy, exercise, medical nutrition therapy, pharmacological and, as a last resort, surgical treatment are recommended. The effect of methods other than surgical treatment on weight loss is slow. For this reason, many obese patients prefer obesity surgery to lose weight quickly, but these methods have many complications such as weight regain, tachycardia, fistula, bleeding, herniation, anastomotic stenosis, gastric erosion, small bowel obstructions, deep vein thrombosis and pulmonary embolism. Post-surgical weight regain and complications have recently led to new searches, and the use of medical nutrition and phytotherapy products has again come to the fore as hope. Phytotherapy products can also be used alone or in combination with other methods. Natural anti-obesity products have functional ingredients such as phytochemicals, polyphenols, flavonoids and phytosterols. There are many natural products used in this field and therefore there are different classifications. Phytotherapeutics are classified according to their effectiveness as those that increase fat burning and stimulate metabolism, suppress appetite, create a feeling of satiety, control blood sugar and insulin, inhibit the absorption of carbohydrates and fats, and inhibit inflammation. However, more clinical research is needed to elucidate the antiobesity effectiveness and mechanism of action of natural products. The risks and side effects of the method to be chosen in obesity treatment should be discussed with the patient. Recommendations to the patient should be given after a multidisciplinary evaluation. Treatment should be started with the most appropriate and least risky method for the patient\"s current condition. It should be explained to the patient that it is most likely that he/she will lose weight with one of these methods, but that the important thing is to maintain his/her weight through behavioral changes.
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    Electrodiagnostic methods to verify Guillain-Barré syndrome subtypes in Istanbul: A prospective multicenter study
    (2024-01-30) TAŞDEMİR V.; Sirin N. G.; Cakar A.; Culha A.; Soysal A.; Elmali A. D.; GÜNDÜZ A.; Arslan B.; Yalcin D.; Atakli D.; et al.; USLU, FERDA; MATUR, ZELİHA
    Background and Aims: This study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain-Barre syndrome (GBS) in Istanbul. Methods: Patients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti-ganglioside antibodies were analyzed. Results: One hundred seventy-seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019-February 2020) and 108 during the pandemic (March 2020-March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.\"s criteria (76/174, 43.7%). Fourteen patients\" diagnoses made using Rajabally et al.\"s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti-ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies. Interpretation: Serial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis.
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    The Challenge of Preoperative Panel Reactive Antibody Positivity in Parathyroid Transplantation
    (2024-02-01) Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Ersoy Y. E.; Akçakaya A.; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; ERSOY, YELIZ EMINE; AKÇAKAYA, ADEM
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    Evaluation of the Relationship Between Delivery Type and Craniofacial Morphology and Condylar Symmetry
    (2024-10-01) Mertoglu I. E.; ŞEKER E. D.; ŞEKER, ELIF DILARA
    Objective: To assess the effects of delivery types on growth patterns and mandibular asymmetry. Methods: One hundred six patients were divided into two groups as those who were born via normal delivery and via cesarean delivery. Skeletal growth patterns were measured on cephalograms using NemoCeph software (Nemotec, Madrid, Spain). The condylar, ramal and total asymmetry indexes were calculated on panoramic radiographs using the Image) software (Image) software, 1.37, National Institutes of Health, Bethesda, Maryland, USA). The mothers of the patients were also asked to respond to questions on their childbirth experiences and the infancy stages of their children. Results: There was no statistically significant difference between the groups in terms of their skeletal, dental and soft tissue parameters on their cephalometric images (p 0.05). No statistically significant difference was observed between the asymmetry index values of the two groups (p 0.05). A significant correlation was observed between the gestational weeks of the patients at birth and their total asymmetry scores (p<0.05). Conclusion: Types of delivery did not affect growth patterns significantly. However, more asymmetric condyles were observed in the normal delivery group, and more ramus asymmetries were observed in cesarean delivery group. There was also a relationship between preterm birth and mandibular asymmetry.
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    A Study on Thymoquinone: Antioxidant Capacity and Anticancer Activities in LoVo Colorectal Cancer Cells
    (2024-02-02) Bozali K.; Metin Guler E.; KOÇYİĞİT A.; KOÇYİĞİT, ABDÜRRAHİM
    Thymoquinone has antioxidant and anticancer effects. This study investigates the cytotoxic, genotoxic, and apoptotic effects of black seed and its active ingredient, thymoquinone on colorectal cancer cells. The antioxidant content of Black seed methanolic extracts (BSME) with different concentrations (50, 500 and 1000 mu g/mL) were determined by the photometric methods. The reactive oxygen production (iROS) of BSME and thymoquinone on colorectal cancer cells (LoVo) and normal epithelial cells (CCD18Co) were analyzed by the fluorometric methods. A luminometric glutathione kit was employed to observe the changes in intracellular glutathione (GSH) levels. Cytotoxicity was determined by the ATP method, genotoxicity was determined by Comet Assay, and the apoptosis was identified by the Acridine Orange/Ethidium Bromide (AO/EB) double dye method. The cytotoxicity was increased by BSME and thymoquinone in LoVo cells in a dose-dependent manner (p<0.001). BSME and thymoquinone also increased iROS, and induced apoptosis and DNA damage (p<0.001). High doses of BSME and thymoquinone on cancer and healthy cells have cytotoxic, genotoxic and apoptotic effects with pro-oxidant effects. Colorectal cancer cells are more sensitive than healthy cells.
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    An Alternative and Up-To-Date Recommendation for a Proper Site for Parathyroid Transplantation: The Omentum
    (2024-02-01) Ersoy Y. E.; Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Akçakaya A.; ERSOY, YELIZ EMINE; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; AKÇAKAYA, ADEM
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    An Investigation into the Relationship of SUR-1TRPM4 Receptor with Peritumoral Edema in High-Grade Glial Tumors.
    (2024-01-01) Dundar T. T.; Seyithanoglu M. H.; Coban G.; Yurtsever I.; Toprak A.; Oztanir M. N.; TOPRAK, ALİ
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    Results of nucleos(t)ide analog treatment discontinuation in hepatitis b e-Antigen-negative chronic hepatitis b: Nucstop study
    Background/Aims: This study aims to investigate the effects of nucleos(t)ide analogs (NAs) discontinuation in eligible patients in accordance with the Asian Pacific Association for the Study of the Liver hepatitis B guideline and the factors affecting clinical and virological relapses. Materials and Methods: In this prospectively designed study, hepatitis B e antigen (HBeAg)-negative chronic hepatitis B patients who were followed up between 2012 and 2019 were evaluated and 57 patients were included. All participants enrolled the study were HBeAgnegative status at NA initiation. Results: The median age of the patients was 49 (29-72) years and 24 (42%) were females. The median treatment duration was 96 (36-276) months and patients were followed for a median duration of 27 months. Sixteen patients had a previous history of NA switch, and thirteen of these patients had a history of lamivudine resistance. Thirty-eight of 57 patients (66%) developed an elevated hepatitis B virus deoxyribonucleic acid level of 2000 IU/mL at least once, defined as virological relapse and 23 (60%) of them, experienced clinical relapse. Thirty-one of 57 patients were re-Treated during the follow-up, and hepatitis B surface antigen (HBsAg) loss occurred among 4 (7%) patients. All patients who experienced HBsAg loss had a history of lamivudine resistance (P = .002). Conclusion: Despite receiving NAs suppression therapy for a long time, HBsAg loss occurs rarely. Although it was not life-Threatening, most patients experienced relapses and treatment should be restarted. In our study, whether it is a coincidence that all patients with HBsAg loss are patients in whom NAs are used sequentially due to lamivudine resistance is an issue that needs to be further investigated.
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    Bemarituzumab as first-line treatment for locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma: final analysis of the randomized phase 2 FIGHT trial.
    (2024-02-03) Wainberg Z. A.; Kang Y.; Lee K.; Qin S.; Yamaguchi K.; Kim I.; Saeed A.; Oh S. C.; Li J.; Turk H. M.; et al.; TÜRK, HACI MEHMET
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    Temperature rise on external root surface during 810- and 970-nm diode laser application in endodontic treatments
    (2024-12-01) Arslan D.; KAPLAN F.; Stoicefidis K.; Dalkılıç E. M.; KAPLAN, FATMA
    Purpose: The aim of this study was to evaluate the temperature rise on the external root surface during 810- and 970-nm diode laser application. Methods: Thirty-six single-rooted mandibular premolar teeth were employed. All of the root canals were prepared at 1 mm short of the apical foramen; after working length determination, each root canal was prepared using ProTaper Universal instruments. The roots were randomly divided into 2 groups of 18 specimens in each. A 810-nm diode laser in group 1 and 970-nm diode laser in group 2 were used with continuous mode and 1.5 W parameters. The temperature elevations were measured with an infrared thermographic camera during 810- and 970-nm diode laser irradiation. Data were analyzed statistically using Kruskal–Wallis and Tukey’s tests. Results: No significant difference was obtained among the 810- and 970-nm diode laser groups according to the temperature changes (P > 0.05). Temperature rise values in all the teeth were detected below 10 °C. Conclusion: Within the limitations of this in vitro study, the 810- and 970-nm diode laser irradiation is a safe supported treatment option when considering the temperature elevation on the external root surface and these lasers can be safely used for endodontic treatments at the investigated parameters. The peak temperature was below the critical value.