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The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report

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dc.contributor.authorKelahmetoğlu, Osman
dc.contributor.authorTok, Enis Olgu
dc.contributor.authorÖzer, Ömer Faruk
dc.contributor.authorYeniocak, Ali
dc.contributor.authorYağmur, Çağlayan
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorKoçyiğit, Abdürrahim
dc.contributor.authorYıldız, Kemalettin
dc.contributor.authorGüneren, Ethem
dc.contributor.institutionauthorKELAHMETOĞLU, OSMAN
dc.contributor.institutionauthorÖZER, ÖMER FARUK
dc.contributor.institutionauthorYENİOCAK, ALİ
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorYILDIZ, KEMALETTİN
dc.contributor.institutionauthorGÜNEREN, ETHEM
dc.date.accessioned2020-08-03T20:59:09Z
dc.date.available2020-08-03T20:59:09Z
dc.date.issued2020-07-01T00:00:00Z
dc.description.abstractObjective: Vitamin D is a vitamin that has gained popularity in recent years and has an anti-inflammatory and immunmodular effect. In the literature review we conducted, there was no study investigating the effect of vitamin D to prevent ischemia reperfusion (I/R) injury in skeletal muscle. The aim of this study was to investigate the effect of vitamin D on skeletal muscle in I/R injury. Methods: Six rats were used in each group including ischemia group (group I) and experimental group (group D given vitamin D). In the histopathological examination, inflammation and apoptosis levels were studied in gastrocnemius muscle. In biochemical analysis, total oxidative stress and total antioxidant and catalase levels were evaluated in anterior tibialis muscle. Results: The number of apoptotic cells in group D were found significantly lower than group I. In the terms of total antioxidants and catalase levels, there were significant difference between group D and group I. Conclusion: Our results support the hypothesis that vitamin D is an agent that can be used to prevent I/R injury.
dc.identifier.citationKelahmetoğlu O., Tok E. O. , Özer Ö. F. , Yeniocak A., Yağmur Ç., Eşrefoğlu M., Koçyiğit A., Yıldız K., Güneren E., -The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report-, Bezmiâlem Science, cilt.8, ss.233-237, 2020
dc.identifier.doi10.14235/bas.galenos.2019.3433
dc.identifier.trdizin376422
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18311
dc.identifier.wosWOS:000560708100005
dc.language.isoen
dc.subjectVitamin D
dc.subjectischemia-reperfusion injury
dc.subjectskeletal muscle
dc.titleThe Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report
dc.typeArticle
dspace.entity.typePublication
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