Person: EŞREFOĞLU, MUKADDES
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Publication Diyabetik sıçanlarda malign serebral iskemi ve iskemik ön koşullanmanın testis dokusu üzerine uzak doku etkilerinin histopatolojik açıdan incelenmesi(2015-12-03) KUMAŞ, MELTEM; ALTINTAS, OZGE; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDESPublication The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine.(2018-01-01) YILDIZ, A; VARDI, N; KARAASLAN, MG; ATES, B; TASLIDERE, ELİF; Esrefoglu, MUKADDES; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage.(2011-10-01) Eşrefoğlu, MUKADDES; GÜL, M; ATES, B; ERDOĞAN, A; EŞREFOĞLU, MUKADDESPublication Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Investigation of Anti-Oxidant and Toxicological Effects Of Methanolic Extract of Rosmarinus officinalis(2015-10-17) BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Comparison of Small-diameter-hole and Traditional Microfracture in Cartilage Repair and the Effect of Adding a Hyaluronic Acid-based Acellular Matrix Scaffold: An Animal Study(2021-03-01T00:00:00Z) UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, Nuh Mehmet; UZER, GÖKÇER; GÜZEL, YUNUS; TOK, OLGU ENİS; Mukaddes, E.; UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; UZER, GÖKÇER; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESObjective: Since, there is no standardized technique for the treatment of focal cartilage defects that can recreate original cartilage tissue; researchers continue to explore and evaluate various treatment modalities. This study compared post-operatke healing of cartilage defects after treatment with small-diameter-hole microfracture (SDHM) technique with that of traditional microfracture technique. The effects of the hole density and augmentation with hyaluronic acid-based acellular matrix (HA-based AM) on cartilage healing were also investigated. Methods: Articular cartilage defects measuring 5 mm in diameter and 3 mm in depth were created in each femoral trochlear groove of 21 New Zealand rabbits. Rabbits were assigned to seven groups comprising six knees each. The rabbits were sacrificed 12 weeks later, and the regenerated cartilage was harvested for histological evaluation using the Wakitani scoring system. Results: All defects were filled with regenerated tissue macroscopically. Group I (14; range 10-14 points) had significantly higher Wakitani score than in groups VI (6; range 1-11 points) and VII (5; range 3-10 points) (p=0.043 and p=0.016, respectively). No significant differences were observed among the other groups. Augmentation with HA-based AM did not contribute to cartilage healing. Conclusion: Improved cartilage healing was observed with increasing SDHM density than with traditional microfracture technique. SDHM combined with HA-based AM implantation did not improve the quality of the regenerated cartilage.Publication Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.(2019-02-01) BULUT, HURİ; ESREFOGLU, MUKADDES; BAYINDIR, NİHAN; Meral, I; CAGLAR, HİFA GÜLRU; SELEK, S; YUCE, BÜŞRA; DOGAN, NAREG; TELOGLU, EMİNE ŞEYDA; SONUC, G; YILDIZ, C; TIFTIK, E; SELEK, ŞAHABETTİN; EŞREFOĞLU, MUKADDES; MERAL, İSMAİL; BULUT, HURI; ÇAĞLAR, HİFA GÜLRU; TELOĞLU, EMİNE ŞEYDA; YÜCE, BÜŞRA; BAYINDIR, NİHANPublication Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats.(2014-03-01) TASLIDERE, ELİF; Esrefoglu, MUKADDES; ELBE, H; CETIN, A; ATES, B; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats(2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.Publication Lokal Randomize Mc Farlane Cilt Flebinin İskemi ve Nekrozunun Önlenmesinde Proxeed Plus ile Hiperbarik Oksijen Tedavilerinin Etkisinin Karşılaştırılması(2018-11-11T00:00:00Z) DOĞAN, REMZİ; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; Bayındır, Nihan; EŞREFOĞLU, MUKADDES; Öroğlu Mirasoğlu, Bengisu; YENİGÜN, ALPER; ÖZTURAN, ORHAN; DOĞAN, REMZI; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; YENİGÜN, ALPER; ÖZTURAN, ORHAN