Preparation and Evaluation of Inflammation Targeted Nano-micellar Formulation of Celecoxib

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Date
2019-07-01Author
BAHADORİ, FATEMEHBuyuk, Ayse Seyma
KOZANOĞLU, Ahmed Serdar
Eskandari, Zahra
ANKARALI, HANDAN
Kepekci Tekkeli, Serife Evrim
Nur Kaleli, Humeyra
KOÇYİĞİT, ABDÜRRAHİM
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Objective: Celecoxib (CLX), brand named Celebrex, which belongs to non-steroidal anti-inflammatory drugs family, selectively inhibits the cytokine related cyclooxygenase-2 isoenzyme and thus, possesses less gastrointestinal side effects, have shown to cause stroke, myocard infarction and even death in some cases. In this study we aimed to target inflammation site using CLX uploaded nano-micelles (nano-CLX) made of poly (lactic-co-glycolic) acid (PLGA) to protect other tissues from its side effects.