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Preparation and Evaluation of Inflammation Targeted Nano-micellar Formulation of Celecoxib

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dc.contributor.authorBAHADORİ, FATEMEH
dc.contributor.authorBuyuk, Ayse Seyma
dc.contributor.authorKOZANOĞLU, Ahmed Serdar
dc.contributor.authorEskandari, Zahra
dc.contributor.authorANKARALI, HANDAN
dc.contributor.authorKepekci Tekkeli, Serife Evrim
dc.contributor.authorNur Kaleli, Humeyra
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorKOZANOĞLU, AHMED SERDAR
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2020-01-14T21:00:09Z
dc.date.available2020-01-14T21:00:09Z
dc.date.issued2019-07-01T00:00:00Z
dc.description.abstractObjective: Celecoxib (CLX), brand named Celebrex, which belongs to non-steroidal anti-inflammatory drugs family, selectively inhibits the cytokine related cyclooxygenase-2 isoenzyme and thus, possesses less gastrointestinal side effects, have shown to cause stroke, myocard infarction and even death in some cases. In this study we aimed to target inflammation site using CLX uploaded nano-micelles (nano-CLX) made of poly (lactic-co-glycolic) acid (PLGA) to protect other tissues from its side effects. Methods: CLX was physically entrapped in PLGA micelles using w/o/w emulsion method, resulted in obtaining mono-dispersed particles with 112 nm size. 50 mg PLGA was able to carry 50 mg CLX in 20 mL (2.5 mg/mL) with encapsulation efficiency of 85%. Rheumatoid arthritis model was achieved by injection of complete Freund's Adjuvant to the hint paw of Wistar rats. Infected groups received oral Celebrex, intravenous (i.v.) Celebrex and nano-CLX. Each group was compared with a healthy control group receiving the drug via the same routes. The obtained serums and the hint paw sizes were studied for 6 hours in 3 time periods. Results: Prostaglandin E2 and tumor necrosis factor-a levels were found to be decreased for longer time period by application of nano-CLX compared to oral and i.v. Celebrex. Interleukin-1 (IL-1) and IL-6 levels showed a dramatic decrease at orally administered Celebrex groups, showing the accumulation of these pro-inflammatory Factors at inflammation area. Conclusion: Based on the hypothesis that the ratio of blood parameters is inversely proportional to accumulation at inflammation site, thus, our nano-formulation is targeted to the tissues in the systemic blood flow and have a better selective inhibition.
dc.identifier.citationBAHADORİ F., Buyuk A. S. , KOZANOĞLU A. S. , Eskandari Z., ANKARALI H., Kepekci Tekkeli S. E. , Nur Kaleli H., KOÇYİĞİT A., -Preparation and Evaluation of Inflammation Targeted Nano-micellar Formulation of Celecoxib-, BEZMIALEM SCIENCE, cilt.7, ss.208-214, 2019
dc.identifier.trdizin324641
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/12765
dc.identifier.wosWOS:000499482100007
dc.subjectTargeted inflammation therapy
dc.subjectCelecoxib
dc.subjectnano drug delivery system
dc.subjectPLGA
dc.subjectCOX2
dc.titlePreparation and Evaluation of Inflammation Targeted Nano-micellar Formulation of Celecoxib
dc.typeArticle
dspace.entity.typePublication
local.avesis.id79149ced-9da1-44bd-ad52-6571c8155d0a
local.publication.isinternational1
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublication6c088fd5-dcdd-4f5d-826e-e0154d8d13ff
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
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