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Now showing 1 - 10 of 65
  • PublicationMetadata only
    Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach
    (2019-10-01T00:00:00Z) BAHADORİ, FATEMEH; Eskandari, Zahra; Ebrahimi, Nabiallah; Bostan, Muge Sennaroglu; EROĞLU, MEHMET SAYIP; Oner, Ebru Toksoy; BAHADORİ, FATEMEH
    This study aimed to develop a PLGA, Levan-based drug delivery system (DDS) of Curcumin using a quality-by-design (QbD) approach to reveal how formulation parameters affect the critical quality attributes (CQAs) of this DDS and to present an optimal design. First, a risk assessment was conducted to determine the impact of various process parameters on the CQAs of the DDS (i.e., average particle size, ZP, encapsulation efficiency and polydispersity index). Plackett-Burman design revealed that potential risk factors were Levan molecular weight, PLGA amount and acetone amount. Then, the optimization of the DDS was achieved through a Box-Behnken Design. The optimum formulation was prepared using low molecular weight Levan (134 kDa), 51.51 mg PLGA and 10 ml acetone. The model was validated and the optimized formulation was further characterized using different physic-chemical methods. The study resulted in the most stable NP with a spherical and uniform shape and physical stability tests indicated its stability for at least 60 days at room temperature. In conclusion, this study was an effort for developing a DDS which solubilizes Curcumin in clinically applicable concentrations.
  • PublicationMetadata only
    Investigation of Anticholinesterase Activity of a Series of Salvia Extractsand the Constituents of Salvia staminea
    (2013-03-01) Topçu, Gülaçtı; Boğa, Mehmet; Kolak, Ufuk; Öztürk, Mehmet; Dirmenci, Tuncay; Bahadori, Fatemeh; Bütün, Burcu; TOPÇU, GÜLAÇTI; BAHADORİ, FATEMEH; BÜTÜN, BURCU
  • PublicationMetadata only
    Can Curcumin be Employed to Promote the Integration of Oncology and Natural Products?
  • PublicationMetadata only
    Interaction of curcumin in a drug delivery system including a composite with poly(lactic-co-glycolic acid) and montmorillonite: a density functional theory and molecular dynamics study
    (2017-10-28) Karatas, D.; Tekin, Adem; Bahadori, FATEMEH; Çelik, Mehmet Sabri; BAHADORİ, FATEMEH
    Phytochemicals such as curcumin have great potential in cancer prevention and treatment. However, instability and low aqueous solubility of free curcumin weaken its anticancer potential. These undesirable problems can be avoided upon loading curcumin into nanoparticles containing biocompatible and biodegradable polymers such as poly lactic-co-glycolic acid (PLGA), liposomes or micelles. The interaction of drugs and release control can be further enhanced upon inclusion of clay minerals into the PLGA containing nanoparticles. Such nanoparticles offer a new way for cancer drug delivery systems. However, the role of the clay mineral in the resulting composite is not fully understood. Therefore, in this study, we carried out systematic adsorption studies of curcumin anticancer drug on montmorillonite (MMT) nanoparticles in the presence of amphiphilic polymer (PLGA) and in an aqueous environment to understand the contribution of the layered clay structure using cluster (B97-D), periodic DFT and molecular dynamics (MD) simulations in acidic and natural pH media. It has been found that MMT has high affinity towards either polymer or drug molecules especially due to vdW interactions. Furthermore, it has been observed that MMT facilitates the release of curcumin. Current findings suggest that a composite consisting of MMT and PLGA might be used to deliver the anticancer agent curcumin.
  • PublicationMetadata only
    Apolipoprotein E4 Mediated Targeting of Blood Brain Barrier Using Nano-Micellar Metal Chelators for Treatment of Alzheimer’s Disease
  • PublicationMetadata only
    Advances in Neurotherapeutic Delivery Technologies
    (2015-01-01) Çomoğlu, Tansel; BAHADORİ, FATEMEH; BAHADORİ, FATEMEH
  • PublicationMetadata only
    Optimization of a new controlled release oral dexketoprofen formulation
    (2018-05-08) Sevim, Bilgesu Beria; Çerçi, Buse Hande; Küçük, Zeynep; BAHADORİ, FATEMEH; Kazdal, Fatma; Eskandari, Zahra; Tırıs, GİZEM; DEMIRAY, MUTLU; BAHADORİ, FATEMEH; TIRIS, GİZEM
  • PublicationMetadata only
    Comparison of cytotoxic, genotoxic and apoptotic effects of naringenin-oxime with its mother compound naringenin on human normal and tumor derived cell lines
    (2015-08-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Koyuncu, Ismail; Dikilitas, Murat; BAHADORİ, FATEMEH; Turkkan, Baki; KOÇYİĞİT, ABDÜRRAHİM; BAHADORİ, FATEMEH
  • PublicationOpen Access
    Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine
    (2014-01-01T00:00:00Z) Bahadori, Fatemeh; Dag, Aydan; Durmaz, Hakan; Cakir, Nese; ONYUKSEL, Hayat; Tunca, Ümit; Topcu, Gulacti; Hızal, Gürkan; BAHADORİ, FATEMEH; DAĞ, AYDAN; TOPÇU, GÜLAÇTI
    Two amphiphilic block copolymers using hydrophobic poly(e-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)(4) type star polymer [(PCL-b-PEG)(4)] and the other one is a Y-shaped PEG-(PCL)(2). A star-shaped polymer (PCL-b-PEG)(4) was prepared by ring-opening polymerization (ROP) of epsilon-caprolactone continued by click reaction of (PCL-azide)(4) and PEG-alkyne. The synthesis of Y-shaped PEG-(PCL)(2) block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of epsilon-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.
  • PublicationMetadata only
    Opportunities and challenges in design and applications of nano drug delivery systems