Show simple item record

dc.contributor.authorÖZÇEKER, DENİZ
dc.contributor.authorYAZICI, MEBRURE
dc.contributor.authorÖZKAYA, EMİN
dc.contributor.authorDİLEK, FATİH
dc.contributor.authorGÜLER, ERAY METİN
dc.contributor.authorGÜLER, NERMİN
dc.contributor.authorKOÇYİĞİT, ABDURRAHİM
dc.contributor.authorTAMAY, ZEYNEP ÜLKER
dc.date.accessioned2019-10-05T21:22:22Z
dc.date.available2019-10-05T21:22:22Z
dc.date.issued2018-01-01
dc.identifier
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7136
dc.description.abstractDilek F, Özçeker D, Güler EM, Özkaya E, Yazıcı M, Tamay Z, Koçyiğit A, Güler N. Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria. Turk J Pediatr 2018; 60: 527-534. Chronic spontaneous urticaria (CSU) is an idiopathic inflammatory disorder. Despite great research progress, the pathogenesis of the disease is still not fully understood. Lipoxins (LXs) are autacoid lipid metabolites that are the first discovered members of a new genus named called `specialized proresolving mediators`. In this study, we aimed to investigate the possible role of LXA4 in the pathogenesis of CSU. Forty-two children with CSU and 25 healthy children were enrolled in the study. The demographic and clinical features of patients were evaluated, autologous serum skin tests (ASSTs), and routine laboratory assessments were performed. Disease activity was determined using the urticaria activity score. An enzyme-linked immunosorbent assay was used to evaluate LXA4 plasma levels. The median value of plasma LXA4 was found to be 60.8 ng/ml (interquartile range, 48.1-71.8) in CSU patients and 137.4 ng/ml (121.4-150.8) in the control group. The difference between the groups was statistically significant (p < 0.001). Additionally, the median plasma LXA4 levels in the ASST-positive patients were significantly reduced compared to the ASST-negative ones (45.8 [36.7-67.6] versus 63.8 [58.3-78.9] ng/ml, respectively, p < 0.05). Our results showed that diminished LXA4 biosynthesis may be a critical part of CSU pathogenesis in children, especially in patients with an autoimmune component.en
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectDİLEK F., ÖZÇEKER D., GÜLER E. M. , ÖZKAYA E., YAZICI M., TAMAY Z. Ü. , KOÇYİĞİT A., GÜLER N., -Plasma lipoxin a4 levels in childhood chronic spontaneous urticaria-, Turkish Journal Of Pediatrics, cilt.60, ss.527, 2018
dc.titlePlasma lipoxin a4 levels in childhood chronic spontaneous urticaria
dc.typeArticle
local.avesis.response7012
local.article.journalnameTurgut Özal Tıp Merkezi Dergisi


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record