Person: YAZICI, MEBRURE
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- PublicationMetadata onlyAlerjik Rinitli Çocuklarda Nazal Staphylococcus aureus Taşıyıcılığı(2017-10-01) DILEK, FATIH; CEYLAN, AYŞE NUR; ÖZKAYA, EMİN; GÜLTEPE, BİLGE; YAZICI, MEBRURE; CEYLAN, AYŞE NUR; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRURE
- PublicationMetadata onlyThe Association Between Paranasal Mucous Retention Cysts and Allergic Sensitization(2021-01-01T00:00:00Z) USTABAŞ KAHRAMAN, Feyza; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; Soylu, Nihal; İŞCAN, AKIN; ÖZKAYA, EMİN; USTABAŞ KAHRAMAN, FEYZA; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; İŞCAN, AKIN; ÖZKAYA, EMİNObjective: Although there is no consensus regarding the etiology of paranasal mucous retention cysts (MRCs) in the literature, several studies suggest an allergic etiology. This study aimed to investigate a potential association between paranasal MRCs diagnosed with MRI scans and allergic sensitization in the pediatric population.
- PublicationMetadata onlyAssociation between myeloperoxidase gene polymorphism and familial mediterranean fever in Turkish Children(2016-01-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ergen, Hayriye Arzu; Dogan, Akif Nuri; Uzuner, SELÇUK; Vehapoglu, Aysel; Yazici, MEBRURE; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRUREBackground: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. Autoinflammatory disorders are characterized by exaggerated immune system responses. Neutrophils and their byproduct, myeloperoxidase, are important components of the innate immune system. In the present study, we searched for myeloperoxidase gene polymorphisms in FMF patients. Methodology/Principal Findings: We evaluated 83 children diagnosed with FMF by their physicians and 93 controls without any family history of FMF. MPO gene polymorphisms were detected using polymerase chain reaction (PCR)-based methods. We genotyped all samples in terms of the -463G/A single-nucleotide polymorphism, the most extensively studied MPO polymorphism. Allelic and genotypic frequencies were calculated, and possible associations with FMF explored. The frequencies of MPO polymorphisms differed significantly between the study and control groups (P = 0.003). The AA and AG gene polymorphisms were more prevalent in the FMF group than in the controls. The A allele was more prevalent in the FMF group (P = 0.001), and the frequency of the G allele was similar between the two groups (P = 0.128). Conclusion: MPO gene polymorphisms and allelic differences may be important in the pathogenesis of FMF.
- PublicationOpen AccessRenal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children(2016-12-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ozkaya, EMİN; Yazici, MEBRURE; Torun, EMEL; Vehapoglu, Aysel; KUCUKKOC, Mehmet; ÖZKAYA, EMİN; YAZICI, MEBRURE; TORUN, EMEL; VEHAPOĞLU TÜRKMEN, AYSELBackground: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NAG, KIM-1, and serum creatinine, sodium, phosphorus were evaluated. The diagnosis of asthma and classification of mild or moderate were done according to the Global Initiative for Asthma guidelines. Results: Serum sodium, phosphorus, creatinine, and urinary microalbumin were within normal levels in the both groups. Urinary pH, sodium, potassium, phosphorus, microalbumin, and KIM-1 excretions were similar between the control and study groups. Tubular phosphorus reabsorption was within normal limits in two groups. Urine NAG was elevated in the study group (P = 0.001). Urinary KIM-1 and NAG levels were positively correlated (r = 0.837; P = 0.001). When children with mild and moderate asthma were compared, all of the parameters were similar (P >0.05). Conclusions: This study showed that chronic asthma can lead to subtle renal impacts. We suggest that in children with asthma, urinary NAG level is a more valuable parameter to show degree of renal tubular injury than markers such as microalbumin and KIM-1. Chronic hypoxy and inflammation probably contributes to these subclinical renal effects.
- PublicationOpen AccessOxidative Stress in Children with Chronic Spontaneous Urticaria(2016-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, Nermin; Tamay, Zeynep; KESGIN, Siddika; Yazici, MEBRURE; Kocyigit, ABDÜRRAHİM; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMThe pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity
- PublicationOpen AccessPlasma levels of matrix metalloproteinase-9 in children with Chronic spontaneous urticaria(2016-01-01) DILEK, Fatih; OZCEKER, Deniz; ÖZKAYA, EMİN; TAMAY, Zeynep; YAZICI, MEBRURE; KESGIN, Siddika; KOÇYİĞİT, ABDÜRRAHİM; GULER, Nermin; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMPurpose: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. Methods: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS). Results: The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P<0.001). Also, MMP-9 levels showed a significant positive correlation with UAS (rho=0.57, P<0.001). Twenty-six percent of patients had positive autologous serum skin test (ASST) results. Neither UAS nor plasma MMP-9 levels were significantly different between ASST-positive and -negative patients (P>0.05). Conclusions: Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.
- PublicationMetadata onlyElevated Nitrosative Stress in Children with Chronic Spontaneous Urticaria(2017-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, ERAY METİN; Yazici, MEBRURE; Tamay, Zeynep; Kocyigit, ABDÜRRAHİM; Guler, Nermin; ÖZKAYA, EMİN; GÜLER, ERAY METİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMBackground: Chronic spontaneous urticaria (CSU) is an idiopathic condition that seriously affects quality of life. It is well known that oxidative stress and nitrosative stress (NS) are generally involved in many chronic inflammatory diseases. This study aimed to evaluate the possible role of NS in the pathogenesis of CSU. Methods: Thirty-two children with CSU and 22 healthy control subjects were enrolled in the study. Demographic and clinical features were defined, and disease activity was quantified using the urticaria activity score (UAS). Serum NS was assessed by the plasma levels of total nitric oxide (NOx) metabolites and nitrite and nitrate measurements using a Griess method -based commercial kit. Results: Plasma NOx levels were 82.5 11.3 mol/L in the CSU group and 50.9 9.4 mol/L in the control group. The difference was statistically significant (p < 0.001). CSU patients also had higher plasma nitrite levels than controls (53.3 13.8 vs. 30.2 10.1 mol/L, respectively, p < 0.001). The median values of plasma nitrate were 27.5 mon (IQR 19.1-35.5) in CSU patients and 20.9 rnol/L (IQR 17.9-23.2) in the control group, and the difference was statistically significant (p = 0.009). In addition, plasma NOx and nitrite levels were positively correlated with the UAS (rho = 0.512, p = 0.03 and rho = 0.452, p = 0.011, respectively). Conclusion: Plasma NS is elevated and positively correlated with disease activity in children with CSU. (C) 2017 S. Ka rger AG, Basel
- PublicationOpen AccessASSESSMENT OF RENAL TUBULAR FUNCTION AND EARLY KIDNEY INJURY BIOMARKERS IN CHILDHOOD ASTHMA(2015-05-01T00:00:00Z) Goknar, Nilufer; Oktem, Faruk; ÖZKAYA, EMİN; YAZICI, MEBRURE; Demir, Aysegul Dogan; TORUN, EMEL; Kucukkoc, Mehmet; ÖZKAYA, EMİN; YAZICI, MEBRURE; TORUN, EMEL; ZORLU, MEHMET
- PublicationOpen AccessPlasma total thiol pool in children with asthma: Modulation during montelukast monotherapy(2016-03-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; Guler, ERAY METİN; DUNDAROZ, Mehmet Rusen; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; GÜLER, ERAY METİNBackground: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. Methods: A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. Results: Bronchial asthma patients in both groups I and II had decreased median TAS levels compared with the control group (1.59 [interquartile range, 1.04–1.70] and 1.67 [1.50–1.75] vs. 2.98 [2.76–3.16] Trolox equiv./L, respectively; P <0.001). Group I had decreased PTT concentrations compared with the control group (0.18 [0.16–0.20] vs. 0.21 [0.19–0.22] mmol/L; P <0.001), and group II had similar PTT levels to the control group (0.20 [0.17–0.22] mmol/L; P >0.05). In addition, the median TAS and PTT levels for groups I and II were not statistically different (P >0.05). There was a positive correlation between TAS and PTT levels (rho = 0.38, P <0.05) in group I. Conclusion: In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.
- PublicationMetadata onlyNasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.