Person: YAZICI, MEBRURE
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Publication Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.Publication Evaluation of nasal fluid beta-defensin 2 levels in children with allergic rhinitis(2017-06-01) DILEK, Fatih; EMIN, Ozkaya; Gultepe, BİLGE; Yazici, MEBRURE; Cakir, ERKAN; GEDIK, Ahmet Hakan; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANAim: Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has been expanding in recent years. Defensins are antimicrobial peptides that are components of the innate immune system. Defensins have strong efficacy against bacterial, viral, and fungal infections. Moreover, they have regulatory functions in many physiologic processes such as antitumoral immunity, chemotaxis, inflammation, and wound healing. In this study, we aimed to investigate a-defensin 2 levels in the nasal fluids of children with allergic rhinitis.Publication Enuresis Nocturna in children with asthma: prevalence and associated risk factors(2016-06-01T00:00:00Z) ÖZKAYA, EMİN; Aydin, Seren Calis; YAZICI, MEBRURE; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; İŞCAN, AKINBackground: Enuresis Nocturna (EN) is a common disorders in childhood. Although many different underlying pathophysiological mechanisms have been proposed to explain EN, its etiology is multifactorial. Some reports demonstrate that there is an association between EN and allergic diseases. To study (1) the prevalence of EN in children with asthma, (2) to determine the possible risk factors for EN in asthmatic children.Publication Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma(2015-01-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; KESGIN, Siddika; GEDIK, Ahmet Hakan; Cakir, ERKAN; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; ÇAKIR, ERKANBackground: There is ample knowledge reported in the literature about the role of oxidative stress in asthma pathogenesis. It is also known that the interaction of reactive oxygen species with DNA may result in DNA strand breaks. The aim of this study was to investigate if montelukast monotherapy affects oxidative stress and DNA damage parameters in a population of pediatric asthma patients. Methods: Group I consisted of 31 newly diagnosed asthmatic patients not taking any medication, and group II consisted of 32 patients who had been treated with montelukast for at least 6 months. Forty healthy control subjects were also enrolled in the study. Plasma total oxidant status (TOS) and total antioxidant status (TAS) were measured to assess oxidative stress. DNA damage was assessed by means of alkaline comet assay. Results: The patients in both group I and group II had statistically significant higher plasma TOS (13.1 ± 4 and 11.1 ± 4.1 μmol H2O2 equivalent/liter, respectively) and low TAS levels (1.4 ± 0.5 and 1.5 ± 0.5 mmol Trolox equivalent/liter, respectively) compared with the control group (TOS: 6.3 ± 3.5 μmol H2O2 equivalent/liter and TAS: 2.7 ± 0.6 mmol Trolox equivalent/liter; p < 0.05). DNA damage was 18.2 ± 1.0 arbitrary units (a.u.) in group I, 16.7 ± 8.2 a.u. in group II and 13.7 ± 3.4 a.u. in the control group. There were statistically significant differences only between group I and the control group (p < 0.05). Conclusions: According to the findings, montelukast therapy makes only minimal but not statistically significant improvement in all TOS, TAS and DNA damage parameters.Publication Elevated Nitrosative Stress in Children with Chronic Spontaneous Urticaria(2017-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, ERAY METİN; Yazici, MEBRURE; Tamay, Zeynep; Kocyigit, ABDÜRRAHİM; Guler, Nermin; ÖZKAYA, EMİN; GÜLER, ERAY METİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMBackground: Chronic spontaneous urticaria (CSU) is an idiopathic condition that seriously affects quality of life. It is well known that oxidative stress and nitrosative stress (NS) are generally involved in many chronic inflammatory diseases. This study aimed to evaluate the possible role of NS in the pathogenesis of CSU. Methods: Thirty-two children with CSU and 22 healthy control subjects were enrolled in the study. Demographic and clinical features were defined, and disease activity was quantified using the urticaria activity score (UAS). Serum NS was assessed by the plasma levels of total nitric oxide (NOx) metabolites and nitrite and nitrate measurements using a Griess method -based commercial kit. Results: Plasma NOx levels were 82.5 11.3 mol/L in the CSU group and 50.9 9.4 mol/L in the control group. The difference was statistically significant (p < 0.001). CSU patients also had higher plasma nitrite levels than controls (53.3 13.8 vs. 30.2 10.1 mol/L, respectively, p < 0.001). The median values of plasma nitrate were 27.5 mon (IQR 19.1-35.5) in CSU patients and 20.9 rnol/L (IQR 17.9-23.2) in the control group, and the difference was statistically significant (p = 0.009). In addition, plasma NOx and nitrite levels were positively correlated with the UAS (rho = 0.512, p = 0.03 and rho = 0.452, p = 0.011, respectively). Conclusion: Plasma NS is elevated and positively correlated with disease activity in children with CSU. (C) 2017 S. Ka rger AG, BaselPublication Çocukluk Çağı Alerjik Rinitinde Nazal Sıvı Beta Defensi2 Düzeylerinin İncelenmesi(2016-04-27) DILEK, FATIH; ÖZKAYA, EMİN; GÜLTEPE, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKAN; GEDIK, AHMET HAKAN; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANPublication Oxidative Stress in Children with Noninfectious Acute Urticaria(2016-03-01T00:00:00Z) ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; Dilek, Fatih; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; İŞCAN, AKINPlasma oxidative stress parameters such as as total oxidant status (TOS) and total antioxidant status (TAS) were well studied in some chronic allergies, but their role is not well known in acute allergic disease such as acute urticaria (AU). The aim of this study is to investigate the oxidative and antioxidative status in children with AU. Eighty-seven children with noninfectious AU and 70 healthy controls were enrolled in the study. Blood samples were taken for complete blood count, serum immunoglobulin E (IgE), and C-reactive protein (CRP) levels routinely and for TOS and TAS. The skin prick test was performed and/or specific IgE assays were performed as indicated. Blood samples were also taken for TAS and TOS in the control group. Forty-eight (55%) of the children with AU were male, 39 (45%) of them were female. Mean ages were 6 +/- 2.02 and 7 +/- 1.38 years in the study and control groups, respectively. TOS levels were significantly high and TAS levels were significantly lower in the acute urticarial group (P < 0.001) than controls. There was no significant correlation between age, total IgE levels, or eosinophil count and TAS and TOS levels in children with AU. Plasma TOS levels are elevated in children with AU. The high level of TOS indicates that children with AU were exposed to severe oxidative stress.Publication Plasma lipoxin a4 levels in childhood chronic spontaneous urticaria(2018-01-01) DİLEK, FATİH; ÖZÇEKER, DENİZ; GÜLER, ERAY METİN; ÖZKAYA, EMİN; YAZICI, MEBRURE; TAMAY, ZEYNEP ÜLKER; KOÇYİĞİT, ABDURRAHİM; GÜLER, NERMİN; GÜLER, ERAY METİN; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMDilek F, Özçeker D, Güler EM, Özkaya E, Yazıcı M, Tamay Z, Koçyiğit A, Güler N. Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria. Turk J Pediatr 2018; 60: 527-534. Chronic spontaneous urticaria (CSU) is an idiopathic inflammatory disorder. Despite great research progress, the pathogenesis of the disease is still not fully understood. Lipoxins (LXs) are autacoid lipid metabolites that are the first discovered members of a new genus named called `specialized proresolving mediators`. In this study, we aimed to investigate the possible role of LXA4 in the pathogenesis of CSU. Forty-two children with CSU and 25 healthy children were enrolled in the study. The demographic and clinical features of patients were evaluated, autologous serum skin tests (ASSTs), and routine laboratory assessments were performed. Disease activity was determined using the urticaria activity score. An enzyme-linked immunosorbent assay was used to evaluate LXA4 plasma levels. The median value of plasma LXA4 was found to be 60.8 ng/ml (interquartile range, 48.1-71.8) in CSU patients and 137.4 ng/ml (121.4-150.8) in the control group. The difference between the groups was statistically significant (p < 0.001). Additionally, the median plasma LXA4 levels in the ASST-positive patients were significantly reduced compared to the ASST-negative ones (45.8 [36.7-67.6] versus 63.8 [58.3-78.9] ng/ml, respectively, p < 0.05). Our results showed that diminished LXA4 biosynthesis may be a critical part of CSU pathogenesis in children, especially in patients with an autoimmune component.Publication Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy(2016-03-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; Guler, ERAY METİN; DUNDAROZ, Mehmet Rusen; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; GÜLER, ERAY METİNBackground: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. Methods: A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. Results: Bronchial asthma patients in both groups I and II had decreased median TAS levels compared with the control group (1.59 [interquartile range, 1.04–1.70] and 1.67 [1.50–1.75] vs. 2.98 [2.76–3.16] Trolox equiv./L, respectively; P <0.001). Group I had decreased PTT concentrations compared with the control group (0.18 [0.16–0.20] vs. 0.21 [0.19–0.22] mmol/L; P <0.001), and group II had similar PTT levels to the control group (0.20 [0.17–0.22] mmol/L; P >0.05). In addition, the median TAS and PTT levels for groups I and II were not statistically different (P >0.05). There was a positive correlation between TAS and PTT levels (rho = 0.38, P <0.05) in group I. Conclusion: In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.Publication Early infant feeding practice and childhood obesity: the relation of breast-feeding and timing of solid food introduction with childhood obesity(2014-11-01) Vehapoglu, AYSEL; Yazici, MEBRURE; DEMIR, Aysegul Dogan; NURSOY, Mustafa; TURKMEN, Serdar; Ozkaya, EMİN; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRURE; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİNObjective: We assessed the association of breast-feeding and timing of solid food introduction with childhood obesity.