Person: GÜLER, ERAY METİN
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Publication Temel Mitokondriyal Tıp(2020-01-01T00:00:00Z) GÜLER, ERAY METİN; GÜLER, ERAY METİNPublication An Overview of COVID-19 Medicines in Current Guidelines(2020-12-01T00:00:00Z) GÖKÇE, MUSTAFA; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; GÜLER, ERAY METİNAn acute respiratory disease caused by a new coronavirus (Severe acute respirotary syndrome-coronavirus-2, previously known as 2019-nCoV), coronavirus disease 2019 (COVID-19), appeared in December 2019 and then has spread rapidly throughout the world starting from China, Japan and South Korea. As of January 30, 2020, the World Health Organization has officially declared the COVID-19 outbreak. Considering the clinical symptoms of COVID-19, it has many symptoms such as high fever, cough, and fatigue. It is reported that this disease is very severe and causes serious consequences such as cytokine storm and acute respiratory distress syndrome in the elderly and those with chronic diseases. Currently, scientists are trying to find a specific antiviral treatment strategy. Various medications such as hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir and favipiravir are currently being applied in clinical trials to test their efficacy and safety worldwide in COVID-19 treatment, and some promising results have been achieved so far. In this review, agents with potential efficacy against COVID-19 are presented in summary.Publication Oleanolik Asit Türevlerinin Sentezi ve Sitotoksik Aktivitelerinin Araştırılması(2017-04-02) TUNCAY, SALİH; ŞENOL, HALİL; GÜLER, ERAY METİN; ÖCAL, NÜKET; SEÇEN, HASAN; KOÇYİĞİT, ABDÜRRAHİM; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; TOPÇU, GÜLAÇTIPublication Investigation of N-terminal Pro Brain Natriuretic Peptide, Oxidative Stress, and Thiol Disulfide Homeostasis in Vitiligo Patients(2020-03-17T00:00:00Z) Kutlu, Büşra; EMİROĞLU, NAZAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; EMİROĞLU, NAZAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication An Optimum Dose of Olive Leaf ExtractImproves Insulin Receptor Substrate-1,Tyrosine Kinase, and Glucose Transporters,While High Doses Have Genotoxic andApoptotic Effects(2019-11-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; Kasap, Burçin; GÜLER, ERAY METİN; Kaleli, Hümeyra Nur; Kesmen, Mustafa; DİKİLİTAŞ, MURAT; Karataş, Ersin; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells(2018-11-01) SEZER, TAHA; ALTINIŞIK, MUHAMMED; GÜLER, ERAY METİN; Kocyigit, Abdurrahim; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİF; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; ÖZDEMİR, MEHMET HAKAN; KOYTAK, İBRAHİM ARİFObjective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times. Material and methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Cells in the control group were not exposed. RPE cell cultures were compared in terms of cell viability, DNA damage, apoptosis rate, and IL-1 ss, IL-6, and TNF- alpha levels. Results: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1 beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group. The rates of early and late apoptosis were also significantly higher at 60 min. There were no statistically significant differences in any of the parameters between the xenon and LED light sources and the control group at 30 or 60 min. Conclusion: New generation lights, xenon, and LED, seem to be safe in terms of RPE cells. Halogen light may cause toxic effects on RPE cells when used for a long time with maximal power output.Publication Reactive Oxygen Species (ROS) in Living Cells(2018-01-01T00:00:00Z) KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; DİKİLİTAŞ, MURAT; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Thymus vulgaris komponenti timol’ün sitotoksik ve apoptotik aktivitelerinin gastrik adenokarsinoma hücrelerinde araştırılması(2015-10-30T00:00:00Z) GÜNEŞ BAYIR, AYŞE; Kızıltan, Huriye Şenay; GÜLER, ERAY METİN; KARATAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Diyabetik Nefropatili Hastalarda Oksidatif Stresin Rolü(2016-03-21T00:00:00Z) Terzioğlu, Cemal; GÜLER, ERAY METİN; Uçak, Sinem; Çakmak, Orhan; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMPublication Investigation Of Effect Of Thymoquinone 5-Fluorouracil On Colon Cancer Both in vitro and in vivo(2018-10-30T00:00:00Z) GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM