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Hipotiroidi Tedavisine Deneysel Alternatif Yöntem: Tiroid Dokusunun Kapsüle Edilmesi. Experimental Alternative Method for the Treatment of Hypothyroidism: Capsulation of the Thyroid Tissue.

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Date
2018-10-01
Author
Yücesan, Emrah
Kanımdan, Ebru
Özten Kandaş, Nur
Başoğlu, Harun
Göncü, Beyza
Ayşan, Erhan
Ersoy, Yeliz Emine
Akbaş, Fahri
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Article
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Abstract
Objective: Hypothyroidism is a clinical condition that affects all age groups. Generally, lifelong medication is required for the treatment. Despite treatment, symptoms that are related to hormone insufficiency and side effects due to long-term medication can be seen. As an alternative approach, thyroid tissue transplantation may be useful, because of its potential to elevate the thyroid hormone levels and thus increase daily quality of life for the patients. Our aim in this study was to detect the in vitro optimal microencapsulation conditions for thyroid tissues with a biocompatible polymer to avoid immune rejection following transplantation. Material and Methods: Thyroid tissues were isolated mechanically, and followed-up in two groups; tissue and capsulated tissue culture. In-vitro capsule formation and morphology were screened using brightfield microscopy and T3 and T4 levels were evaluated biochemically throughout 60 days. Results: T3 and T4 levels were screened from collected medium samples at day 3., 9., 12., 15., 30., 45., 60.. In capsuled tissues T3 level was detected higher than the non-capsuled and negative control tissues from day 15. However, T4 level was stable for 60 days.
Subject
Yücesan E., Göncü B., Başoğlu H., Özten Kandaş N., Kanımdan E., Akbaş F., Ersoy Y. E. , Ayşan E., -Hipotiroidi Tedavisine Deneysel Alternatif Yöntem: Tiroid Dokusunun Kapsüle Edilmesi. Experimental Alternative Method for the Treatment of Hypothyroidism: Capsulation of the Thyroid Tissue. -, Akdeniz Tıp Dergisi / Akdeniz Medical Journal , no.1017954, ss.1122, 2018
URI
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/14010
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS