Hipotiroidi Tedavisine Deneysel Alternatif Yöntem: Tiroid Dokusunun Kapsüle Edilmesi. Experimental Alternative Method for the Treatment of Hypothyroidism: Capsulation of the Thyroid Tissue.
Date
2018-10-01Author
Yücesan, EmrahKanımdan, Ebru
Özten Kandaş, Nur
Başoğlu, Harun
Göncü, Beyza
Ayşan, Erhan
Ersoy, Yeliz Emine
Akbaş, Fahri
Advisor
Type
Metadata
Show full item recordAbstract
Objective: Hypothyroidism is a clinical condition that affects all age groups. Generally, lifelong
medication is required for the treatment. Despite treatment, symptoms that are related to hormone
insufficiency and side effects due to long-term medication can be seen. As an alternative approach,
thyroid tissue transplantation may be useful, because of its potential to elevate the thyroid hormone
levels and thus increase daily quality of life for the patients. Our aim in this study was to detect the in
vitro optimal microencapsulation conditions for thyroid tissues with a biocompatible polymer to avoid
immune rejection following transplantation.
Material and Methods: Thyroid tissues were isolated mechanically, and followed-up in two groups;
tissue and capsulated tissue culture. In-vitro capsule formation and morphology were screened using
brightfield microscopy and T3 and T4 levels were evaluated biochemically throughout 60 days.
Results: T3 and T4 levels were screened from collected medium samples at day 3., 9., 12., 15., 30.,
45., 60.. In capsuled tissues T3 level was detected higher than the non-capsuled and negative control
tissues from day 15. However, T4 level was stable for 60 days.
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