The Effect of Serum Bone Sialoprotein Levels on Tympanosclerosis

Abstract

Objective: This study aimed to investigate serum bone sialoprotein (BSP) levels in patients with tympanosclerosis (TS).

Methods: We included into this study 24 patients with TS and 24 asymptomatic healthy volunteers. Our study consisted of two groups: TS group (n=24), comprising of patients who underwent surgery for chronic otitis media and had tympanosclerotic plaques; and a control group (n=24), comprising of healthy individuals without ear problems. The serum BSP levels were measured and the results were compared between the two groups.

Results: In the TS group, there were 15 female and nine male patients. The ages of the females ranged from 24 to 54 years, while those of the males ranged from 34 to 55 years; the average age was 40.46 +/- 9.75 and 43.11 +/- 6.77, respectively. In the control group, there were 14 females and ten males. The ages of the females ranged from 30 to 48 years, while those of the males ranged from 27 to 47 years; the average age was 40.25 +/- 5.28 and 38.4 +/- 27.08, respectively. There was a statistically significant difference in BSP levels between the two groups (p=0.001). In addition, there was a moderate positive correlation between BSP and hearing levels.

Conclusion: The serum BSP levels were higher in the TS group than in the control group and might have some effect on TS. Further studies on a large number of subjects using serum and tissue BSP levels should be designed to affirm the effects of BSP on TS.