Person: ÇAĞLAR, HİFA GÜLRU
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Publication Open Access The Effect of Serum Bone Sialoprotein Levels on Tympanosclerosis(2020-07-01T00:00:00Z) Baki, Ahmet; Yildiz, Muhammet; ÖZER, Ömer Faruk; ÇAĞLAR, Hifa Gülru; ÖZER, ÖMER FARUK; ÇAĞLAR, HİFA GÜLRUObjective: This study aimed to investigate serum bone sialoprotein (BSP) levels in patients with tympanosclerosis (TS). Methods: We included into this study 24 patients with TS and 24 asymptomatic healthy volunteers. Our study consisted of two groups: TS group (n=24), comprising of patients who underwent surgery for chronic otitis media and had tympanosclerotic plaques; and a control group (n=24), comprising of healthy individuals without ear problems. The serum BSP levels were measured and the results were compared between the two groups. Results: In the TS group, there were 15 female and nine male patients. The ages of the females ranged from 24 to 54 years, while those of the males ranged from 34 to 55 years; the average age was 40.46 +/- 9.75 and 43.11 +/- 6.77, respectively. In the control group, there were 14 females and ten males. The ages of the females ranged from 30 to 48 years, while those of the males ranged from 27 to 47 years; the average age was 40.25 +/- 5.28 and 38.4 +/- 27.08, respectively. There was a statistically significant difference in BSP levels between the two groups (p=0.001). In addition, there was a moderate positive correlation between BSP and hearing levels. Conclusion: The serum BSP levels were higher in the TS group than in the control group and might have some effect on TS. Further studies on a large number of subjects using serum and tissue BSP levels should be designed to affirm the effects of BSP on TS.Publication Metadata only Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.(2019-02-01) BULUT, HURİ; ESREFOGLU, MUKADDES; BAYINDIR, NİHAN; Meral, I; CAGLAR, HİFA GÜLRU; SELEK, S; YUCE, BÜŞRA; DOGAN, NAREG; TELOGLU, EMİNE ŞEYDA; SONUC, G; YILDIZ, C; TIFTIK, E; SELEK, ŞAHABETTİN; EŞREFOĞLU, MUKADDES; MERAL, İSMAİL; BULUT, HURI; ÇAĞLAR, HİFA GÜLRU; TELOĞLU, EMİNE ŞEYDA; YÜCE, BÜŞRA; BAYINDIR, NİHANPublication Metadata only Oxidative stress and phenotype frequencies of paraoxonase-1 in teratozoospermia.(2019-04-22) AKBULUT, H; Ozer, OF; GULER, ERAY METİN; CAGLAR, HİFA GÜLRU; GEVHER, FATİH; KOKTASOGLU, FATMANUR; SELEK, S; ÖZER, ÖMER FARUK; AKBULUT, HABİB; GÜLER, ERAY METİN; ÇAĞLAR, HİFA GÜLRU; GEVHER, FATİH; KÖKTAŞOĞLU, FATMANUR; SELEK, ŞAHABETTİNOxidative stress causes infertility in men by affecting especially sperm morphology. The aim of the study was to examine the frequencies of paraoxonase-1 (PON1) phenotypes and the serum PON1, arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, catalase and thiol levels in teratozoospermic infertile men and normospermic fertile men. The study included 184 teratozoospermic infertile men and 72 normospermic fertile men. The double substrate method was employed to determine the phenotype distribution of PON1. The evaluation of sperm morphology was made in accordance with the Kruger-s criteria. TAS, catalase and thiol levels were determined to be significantly lower in teratozoospermic infertile men compared to normospermic fertile men. A significant change was not observed in the levels of TOS, PON1 and arylesterase. There was a positive correlation between catalase and thiol levels and sperm morphology. While there were significantly more teratozoospermic men with AA phenotypes compared to normospermic men, there were significantly more persons with AB and BB phenotypes in normospermic men than in teratozoospermic men. As far as we know, such a study was conducted for the first time and suggests that PON1 phenotypic distribution may play a significant role in sterile males because of impaired sperm morphology.Publication Open Access Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor(2016-10-13) Kılıç, Elif; Ozer, Omer Faruk; Erek, Aybala Toprak; ERMAN, HAYRİYE; Torun, EMEL; AYHAN, Siddika Kesgin; Caglar, HİFA GÜLRU; Selek, Sahbettin; Kocyigit, ABDÜRRAHİM; ÖZER, ÖMER FARUK; TORUN, EMEL; ÇAĞLAR, HİFA GÜLRU; SELEK, ŞAHABETTİN; KOÇYİĞİT, ABDÜRRAHİMBackground: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status. Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test. Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 µmol Trolox eq/L (1.7–3.3)) and TOS (med: 49.1 µmol H2 O2 eq/L (34.5–78.8)) levels and TTL (med: 0.22 mmol/L (0.16–0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=–0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=–0.347). Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complicationsPublication Metadata only The evaluation of antioxidant and anticancer effects of Lepidium Sativum Subsp Spinescens L. methanol extract on cancer cells(2018-01-01) Selek, Sahabettin; Koyuncu, Ismail; ÇAĞLAR, HİFA GÜLRU; Bektas, Ibrahim; Yilmaz, Mustafa Abdullah; Gonel, Ataman; Akyuz, ENES; SELEK, ŞAHABETTİN; ÇAĞLAR, HİFA GÜLRU; AKYÜZ, ENES