Parathyroid allotransplantation in rabbits without cultivation.
Date
2014-01-15Author
BUYUKPINARBASILI, NURAysan, E
CAN, I
YUCESAN, E
SAYITOGLU, M
OZBEK, U
MUSLUMANOGLU, M
ATASOY, H
ERCIVAN, M
Advisor
Type
Metadata
Show full item recordAbstract
Permanent hypoparathyroidism is a serious clinical situation. Allotransplantation of the parathyroid cells
is relatively new approach to treatment. Non-cultivated allotransplantation in rabbits is not tried before. In this
research parathyroidectomy was performed in six female New Zealand white rabbits. After division of surgically
removed tissues into two, cryopreservation after cell isolation was done. Non-cultivated cross allotransplantation
was performed under immunosuppression. Serum calcium and phosphorus levels were observed 15 days and
histopathological analyses of the transplanted parathyroid tissues were studied. Significant changes in serum calcium and phosphorus levels during the experiment were observed (p=0.001 for both). Calcium levels which were
significantly dropped to 6.66±0.7 mg/dL after parathyroidectomy and progressively increased up to 15.98±1.25
mg/dL at the end of the experiment (p=0.004). Phosphorus levels which were increased to 9.38±0.63 mg/dL after
parathyroidectomy and stabilized to 4.46±1.06 mg/dL at the end of the experiment (p=0.007). All allotransplanted
parathyroid tissues showed normal tissue architecture without evidence of cellular rejection. In conclusion allotransplantation of the parathyroid tissues without cultivation may be considered as an alternative and safe approach for
the treatment of permanent hypoparathyroidism.
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