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Parathyroid allotransplantation in rabbits without cultivation.

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dc.contributor.authorCAN, I
dc.contributor.authorYUCESAN, E
dc.contributor.authorAysan, E
dc.contributor.authorSAYITOGLU, M
dc.contributor.authorOZBEK, U
dc.contributor.authorERCIVAN, M
dc.contributor.authorATASOY, H
dc.contributor.authorBUYUKPINARBASILI, NUR
dc.contributor.authorMUSLUMANOGLU, M
dc.contributor.institutionauthorAYŞAN, MUSTAFA ERHAN
dc.contributor.institutionauthorYÜCESAN, EMRAH
dc.contributor.institutionauthorBÜYÜKPINARBAŞILI, NUR
dc.date.accessioned2019-10-05T22:17:44Z
dc.date.available2019-10-05T22:17:44Z
dc.date.issued2014-01-15
dc.description.abstractPermanent hypoparathyroidism is a serious clinical situation. Allotransplantation of the parathyroid cells is relatively new approach to treatment. Non-cultivated allotransplantation in rabbits is not tried before. In this research parathyroidectomy was performed in six female New Zealand white rabbits. After division of surgically removed tissues into two, cryopreservation after cell isolation was done. Non-cultivated cross allotransplantation was performed under immunosuppression. Serum calcium and phosphorus levels were observed 15 days and histopathological analyses of the transplanted parathyroid tissues were studied. Significant changes in serum calcium and phosphorus levels during the experiment were observed (p=0.001 for both). Calcium levels which were significantly dropped to 6.66±0.7 mg/dL after parathyroidectomy and progressively increased up to 15.98±1.25 mg/dL at the end of the experiment (p=0.004). Phosphorus levels which were increased to 9.38±0.63 mg/dL after parathyroidectomy and stabilized to 4.46±1.06 mg/dL at the end of the experiment (p=0.007). All allotransplanted parathyroid tissues showed normal tissue architecture without evidence of cellular rejection. In conclusion allotransplantation of the parathyroid tissues without cultivation may be considered as an alternative and safe approach for the treatment of permanent hypoparathyroidism.en
dc.identifier
dc.identifier.citationCAN I., Aysan E., YUCESAN E., SAYITOGLU M., OZBEK U., ERCIVAN M., ATASOY H., BUYUKPINARBASILI N., MUSLUMANOGLU M., -Parathyroid allotransplantation in rabbits without cultivation.-, International journal of clinical and experimental medicine, cilt.7, ss.280-4, 2014
dc.identifier.pubmed24482717
dc.identifier.scopus84892579685
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9326
dc.identifier.wosWOS:000333151200034
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleParathyroid allotransplantation in rabbits without cultivation.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameMarmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
local.avesis.ide80b7254-3f1d-4ca3-85f8-2f4a83be8476
local.avesis.response9202
local.publication.isinternational1
relation.isAuthorOfPublication886ea820-98fa-449a-8b4b-26efeff939d8
relation.isAuthorOfPublication9ea2b80f-531b-49a7-83ef-723bfd8584b2
relation.isAuthorOfPublication07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
relation.isAuthorOfPublication.latestForDiscovery07a102ad-e53c-46b9-b3aa-bdb5723b1e7c
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