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dc.contributor.authorTekkeli, Serife Evrim Kepekci
dc.contributor.authorOnal, Armagan
dc.contributor.authorBahadori, FATEMEH
dc.date.accessioned2019-10-05T21:38:36Z
dc.date.available2019-10-05T21:38:36Z
dc.date.issued2013-01-01
dc.identifier
dc.identifier.citationTekkeli S. E. K. , Onal A., Bahadori F., -Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations-, JOURNAL OF SPECTROSCOPY, 2013
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7834
dc.identifier.urihttps://www.hindawi.com/journals/jspec/2013/919180/
dc.description.abstractThis study presents three simple, rapid, and accurate spectrophotometric methods for the determination of Rasagiline (RSG) in pharmaceutical preparations. The determination procedures depend on the reaction of RSG with chloranilic acid for method A, tetrachloro-1,4-benzoquinone for method B, and 7,7,8,8-tetracyanoquinodimethane for method C. The colored products were quantitated spectrophotometrically at 524, 535, and 843 nm for methods A, B, and C, respectively. Different variables affecting the reaction were optimized. Linearity ranges of the methods with good correlation coefficients (0.9988-0.9996) were observed as 25-300 mu g mL(-1), 25-350 mu g mL(-1), and 50-500 mu g mL(-1) for methods A, B, and C, respectively. The formation of products takes place through different mechanisms. The sites of interaction were confirmed by elemental analysis using IR and H-1-NMR spectroscopy. The validation of the methods was carried out in terms of specificity, linearity, accuracy, precision, robustness, limit of detection, and limit of quantitation. No interference was observed from concomitants usually present in dosage forms. The methods were applied successfully to the determination of RSG in pharmaceutical preparations.
dc.language.isoen
dc.subjectRasagiline
dc.titleDevelopment and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations
dc.typeArticle
local.avesis.response7710
local.article.journalnameTurkish Journal of Dermatopathology
dc.identifier.wosWOS:000324203000001
dc.identifier.scopus84884228699
dc.identifier.doi10.1155/2013/919180
local.publication.isinternational1
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM


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