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Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations

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dc.contributor.authorTekkeli, Serife Evrim Kepekci
dc.contributor.authorOnal, Armagan
dc.contributor.authorBahadori, FATEMEH
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.date.accessioned2019-10-05T21:38:36Z
dc.date.available2019-10-05T21:38:36Z
dc.date.issued2013-01-01
dc.description.abstractThis study presents three simple, rapid, and accurate spectrophotometric methods for the determination of Rasagiline (RSG) in pharmaceutical preparations. The determination procedures depend on the reaction of RSG with chloranilic acid for method A, tetrachloro-1,4-benzoquinone for method B, and 7,7,8,8-tetracyanoquinodimethane for method C. The colored products were quantitated spectrophotometrically at 524, 535, and 843 nm for methods A, B, and C, respectively. Different variables affecting the reaction were optimized. Linearity ranges of the methods with good correlation coefficients (0.9988-0.9996) were observed as 25-300 mu g mL(-1), 25-350 mu g mL(-1), and 50-500 mu g mL(-1) for methods A, B, and C, respectively. The formation of products takes place through different mechanisms. The sites of interaction were confirmed by elemental analysis using IR and H-1-NMR spectroscopy. The validation of the methods was carried out in terms of specificity, linearity, accuracy, precision, robustness, limit of detection, and limit of quantitation. No interference was observed from concomitants usually present in dosage forms. The methods were applied successfully to the determination of RSG in pharmaceutical preparations.
dc.identifier
dc.identifier.citationTekkeli S. E. K. , Onal A., Bahadori F., -Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations-, JOURNAL OF SPECTROSCOPY, 2013
dc.identifier.doi10.1155/2013/919180
dc.identifier.scopus84884228699
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7834
dc.identifier.urihttps://www.hindawi.com/journals/jspec/2013/919180/
dc.identifier.wosWOS:000324203000001
dc.language.isoen
dc.subjectRasagiline
dc.titleDevelopment and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTurkish Journal of Dermatopathology
local.avesis.idc298ce22-43fd-4cc4-860f-24522a5febd5
local.avesis.response7710
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
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