Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3

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Date
2019-01-01
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KOÇYİĞİT, ABDÜRRAHİM
Khan, Imran
Akdur, Kerime
HATİBOĞLU, MUSTAFA AZİZ
GÜLER, ERAY METİN
TÜZGEN, SAFFET
Karataş, Ersin
Nalli, Arife
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Abstract
BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.
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https://hdl.handle.net/20.500.12645/7339
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