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dc.contributor.authorEKİN, ZÜBEYDE YILDIRIM
dc.contributor.authorİLBEY, YUSUF ÖZLEM
dc.contributor.authorEKİN, RAHMİ GÖKHAN
dc.contributor.authorSILAY, MESRUR SELÇUK
dc.contributor.authorKIZILTAN, HURİYE ŞENAY
dc.contributor.authorÇAY, ALİ
dc.contributor.authorMİRAPOĞLU, SEMİH LÜTFİ
dc.contributor.authorÇOBAN, GANİME
dc.contributor.authorAYDOĞDU, İBRAHİM
dc.contributor.authorSEMERCİ, MEHMET BÜLENT
dc.date.accessioned2019-10-05T15:22:41Z
dc.date.available2019-10-05T15:22:41Z
dc.date.issued2019-03-01
dc.identifier10.1007/s13277-012-0481-5
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6149
dc.description.abstractObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)‑induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid‑reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation‑induced testicular damage. OT may be beneficial to the patients who underwent RT.en
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAYDOĞDU İ., İLBEY Y. Ö. , ÇOBAN G., EKİN R. G. , MİRAPOĞLU S. L. , ÇAY A., KIZILTAN H. Ş. , EKİN Z. Y. , SILAY M. S. , SEMERCİ M. B. , -Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?-, JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.15, ss.76-81, 2019
dc.titleDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?
dc.typeArticle
local.avesis.response6019
local.article.journalnameTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine


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