Person: ÇAY, ALI
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ÇAY
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ALI
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- PublicationMetadata onlyDoes ozone administration have a protective effect against cisplatin-induced histological changes in rat testis?(2017-01-01) Aydogdu, Ibrahim; EKIN, Rahmi G.; Yildiz, PELİN; MIRAPOGLU, Semih L.; Cay, ALİ; KILINCASLAN, Huseyin; SEMERCİ, MEHMET BÜLENT; ILBEY, Yusuf O.; AYDOĞDU, İBRAHİM; ÇAY, ALI
- PublicationMetadata onlyPerfore apandisit: Etkenlerin ve enfeksiyon belirteçlerinin klinik iyileşme ve antibiyotik seçimine etkisi(2017-10-28) MIRAPOGLU, S. L.; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALİ; GÜLTEPE, BİLGE; AYDOĞDU, İBRAHİM; TÜREL, ÖZDEN; ÇAY, ALI; SÜMBÜL, BİLGE
- PublicationMetadata onlyDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury(2019-03-01T00:00:00Z) Aydogdu, Ibrahim; Ilbey, YUSUF ÖZLEM; ÇOBAN, GANİME; Ekin, Rahmi Gokhan; Mirapoglu, Semih Lutfi; Cay, Ali; Kiziltan, Huriye Senay; Ekin, Zubeyde Yildirim; Silay, Mesrur Selcuk; SEMERCİ, MEHMET BÜLENT; AYDOĞDU, İBRAHİM; İLBEY, YUSUF ÖZLEM; ÇOBAN, GANİME; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALI; KIZILTAN, HURİYE ŞENAYObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation-induced testicular damage. OT may be beneficial to the patients who underwent RT.
- PublicationMetadata onlyMediastinal nöroenterik kist prenatal tanı ve literatürün gözden geçirilmesi(2016-10-30) ÇAY, ALİ; AYDOĞDU, İBRAHİM; ÇAY, ALI; AYDOĞDU, İBRAHİM
- PublicationMetadata onlyA study on the effects of insufflation gases employed in laparoscopy on various organs: a rat model(2018-09-28T00:00:00Z) MIRAPOGLU, SEMIH L.; YILDIRIM, DOĞAN; ŞAHİN, KAMİL; SARAC, FATMA; AYDOĞDU, İBRAHİM; HUT, ADNAN; ÇAKIR, MİKAİL; DÖNMEZ, TURGUT; ÇOBAN, GANİME; ÜNVER, NURCAN; ÖZER, ÖMER FARUK; ÇAY, ALİ; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; ÜNVER, NURCAN; ÖZER, ÖMER FARUK; ÇAY, ALI
- PublicationMetadata onlyCisplatine bağlı rat testisinde meydana gelen histopatolojik değişikliklere karşı ozon tedavisinin koruyucu bir etkisi var mıdır?(2017-10-28) AYDOĞDU, İBRAHİM; EKİNCİ, RAHMİ GÖKHAN; YILDIZ, PELİN; MIRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALİ; SEMERCİ, MEHMET BÜLENT; İLBEY, YUSUF ÖZLEM; AYDOĞDU, İBRAHİM; YILDIZ, PELİN; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALI
- PublicationMetadata onlyIRF4 Positivity is a Novel Diagnostic and Prognostic Marker for Diffuse Large B Cell Lymphoma(2018-11-01T00:00:00Z) GÜLER, Beril; ÇAKIR, FATMA BETÜL; Cay, A.; Mirapoglu, S.; Turkmen, A. Vehaboglu; Aki, H.; ÇAKIR, FATMA BETÜL; GÜLER, BERIL; ÇAY, ALI
- PublicationMetadata onlyRadyoterapiye bağlı rat testisinde meydana gelen histolojik değişiklikler üzerine ozon tedavisinin koruyucu bir etkisi var mıdır?(2016-10-30) İLBEY, YUSUF ÖZLEM; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; EKİNCİ, RAHMİ GÖKHAN; MIRAPOGLU, S. L.; ÇAY, ALİ; KIZILTAN, HURİYE ŞENAY; SILAY, MESRUR SELÇUK; SEMERCİ, MEHMET BÜLENT; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; ÇAY, ALI; KIZILTAN, HURİYE ŞENAY
- PublicationMetadata onlyEffects of carbon dioxide pneumoperitoneum on exocrine and endocrine functions, and oxidative state of rat pancreas(2020-07-01T00:00:00Z) Sag, Sefa; İMAMOĞLU, MUSTAFA; SARIHAN, HALUK; YULUĞ, ESİN; ALVER, AHMET; GEZE SAATÇI, ŞÜKRAN; ÇAY, Ali; ÇAY, ALIWe investigated the effects of increased intra-abdominal pressure during laparoscopy on the endocrine and exocrine functions, oxidative stress and histopathology of the pancreas in rats. We established three experimental groups of eight animals. Group 1 was the untreated control. Forth other two groups, pneumoperitoneum with CO(2)was established for 60 min at 6 mm Hg for group 2 and 12 mm Hg for group 3; groups 2 and 3 animals were allowed to re-perfuse for 30 min. Amylase, glucagon and insulin levels were analyzed in blood samples and insulin:glucagon ratio was calculated. Histopathology and malondialdehyde assay were performed on pancreatic tissue samples. Histological damage scores for vasocongestion were increased significantly in groups 2 and 3 compared to group 1. Histological damage scores for inflammatory cell infiltration were increased significantly in group 3 compared to group 1. Malondialdehyde levels were increased significantly in group 3 compared to group 1. We found no significant differences among groups for serum amylase levels or histological damage scores for hemorrhage. Insulin and glucagon levels, and the insulin:glucagon ratio was increased significantly in group 3 compared to groups 1 and 2. We found that in rats routine laparoscopy caused increased serum insulin and glucagon levels, and histopathological changes that indicated ischemia-reperfusion injury to the pancreas.
- PublicationOpen AccessDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?(2019-03-01) AYDOĞDU, İBRAHİM; İLBEY, YUSUF ÖZLEM; ÇOBAN, GANİME; EKİN, RAHMİ GÖKHAN; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALİ; KIZILTAN, HURİYE ŞENAY; EKİN, ZÜBEYDE YILDIRIM; SILAY, MESRUR SELÇUK; SEMERCİ, MEHMET BÜLENT; AYDOĞDU, İBRAHİM; ÇOBAN, GANİME; MİRAPOĞLU, SEMİH LÜTFİ; ÇAY, ALI; KIZILTAN, HURİYE ŞENAYObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)‑induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid‑reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation‑induced testicular damage. OT may be beneficial to the patients who underwent RT.