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Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?

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dc.contributor.authorAYDOĞDU, İBRAHİM
dc.contributor.authorİLBEY, YUSUF ÖZLEM
dc.contributor.authorÇOBAN, GANİME
dc.contributor.authorEKİN, RAHMİ GÖKHAN
dc.contributor.authorMİRAPOĞLU, SEMİH LÜTFİ
dc.contributor.authorÇAY, ALİ
dc.contributor.authorKIZILTAN, HURİYE ŞENAY
dc.contributor.authorEKİN, ZÜBEYDE YILDIRIM
dc.contributor.authorSILAY, MESRUR SELÇUK
dc.contributor.authorSEMERCİ, MEHMET BÜLENT
dc.contributor.institutionauthorAYDOĞDU, İBRAHİM
dc.contributor.institutionauthorÇOBAN, GANİME
dc.contributor.institutionauthorMİRAPOĞLU, SEMİH LÜTFİ
dc.contributor.institutionauthorÇAY, ALI
dc.contributor.institutionauthorKIZILTAN, HURİYE ŞENAY
dc.date.accessioned2019-10-05T15:22:41Z
dc.date.available2019-10-05T15:22:41Z
dc.date.issued2019-03-01
dc.description.abstractObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)‑induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid‑reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation‑induced testicular damage. OT may be beneficial to the patients who underwent RT.en
dc.identifier10.1007/s13277-012-0481-5
dc.identifier.citationAYDOĞDU İ., İLBEY Y. Ö. , ÇOBAN G., EKİN R. G. , MİRAPOĞLU S. L. , ÇAY A., KIZILTAN H. Ş. , EKİN Z. Y. , SILAY M. S. , SEMERCİ M. B. , -Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?-, JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.15, ss.76-81, 2019
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6149
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
local.avesis.id98cb1c51-7c39-45d7-82f0-8e04fe5dcbb6
local.avesis.response6019
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relation.isAuthorOfPublication92813154-621b-468c-8399-8510ae43f718
relation.isAuthorOfPublication63bd3451-720b-4982-b346-514afe67acdb
relation.isAuthorOfPublication28be09fc-1b74-40b6-a69e-55cbf052b2dc
relation.isAuthorOfPublication91868cfc-cd33-4b57-98b2-792bfc24eedb
relation.isAuthorOfPublication.latestForDiscovery92813154-621b-468c-8399-8510ae43f718
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