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dc.contributor.authorCan, Ismail
dc.contributor.authorAysan, Erhan
dc.contributor.authorBuyukpinarbasili, NUR
dc.contributor.authorDUZKOYLU, Yigit
dc.date.accessioned2019-10-05T13:32:12Z
dc.date.available2019-10-05T13:32:12Z
dc.date.issued2017-06-01
dc.identifier10.1111/j.1525-1594.2011.01378.x
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2321
dc.description.abstractObjective: Parathyroid allotransplantation is a new method for the treatment of permanent hypoparathyrodism. Adenoma cells are not used for transplantation because of the potential for functional or histopathologic transformation. In this study, we transplanted human adenomatous parathyroid cells to rabbits. Material and Methods: Parathyroid adenoma tissue taken from a male patient was cryopreserved and transplanted into seven New Zealand white rabbits (mean weight, 3700±220 g; mean age, 4.5 months) under immunosuppression. The levels of parathormone, calcium and phosphorus were measured before and after transplantation, and the parathyroid cells were observed histopathologically. Results: Mean parathyroid hormone level was 0.5 pg/dL before transplantation and 6.6 pg/dL after transplantation (p<0.05). Preoperative mean calciumlevel was 14.1 mg/dL, and mean phosporus level was 3.5 mg/dL before transplantation while these values were 14.4 mg/dL and 3.3mg/dL, respectively, after transplantation (p>0.05). Morphologic transformation was not observed in parathyroid cells after transplantation. Conclusion: In short-term observation, adenomatous parathyroid cells can function without malignant transformation. In the future, the preliminary methodology in this study may serve as a safe alternative for allotransplantation into patients with permanent hypoparathyroidism. Keywords: Hypoparathyroidism, xenotransplantation, parathyroid adenomaen
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectAysan E., DUZKOYLU Y., Can I., Buyukpinarbasili N., -Xenotransplantation of human cryopreserved parathyroid tissue isolated from parathyroid adenomas to normocalcemic rabbits-, TURKISH JOURNAL OF SURGERY, cilt.33, ss.91-95, 2017
dc.titleXenotransplantation of human cryopreserved parathyroid tissue isolated from parathyroid adenomas to normocalcemic rabbits
dc.typeArticle
local.avesis.response2191
local.article.journalnameArtificial organs
dc.identifier.wosWOS:000403585500010
dc.identifier.scopus85020554189
dc.identifier.doi10.5152/turkjsurg.2017.3427
dc.identifier.pubmed28740957
local.publication.isinternational1


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