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dc.contributor.authorPirmit, Serpil
dc.contributor.authorRezvani, Aylin
dc.contributor.authorÇelik, Şirin
dc.contributor.authorOzkaya, Dilek
dc.contributor.authorONSUN, NAHİDE
dc.contributor.authorKekik, Cigdem
dc.contributor.authorCENGİZ, Fatma Pelin
dc.date.accessioned2020-01-19T20:59:17Z
dc.date.available2020-01-19T20:59:17Z
dc.date.issued2019-01-01T00:00:00Z
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13417
dc.description.abstractBackground. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectONSUN N., Pirmit S., Ozkaya D., Çelik Ş., Rezvani A., CENGİZ F. P. , Kekik C., -The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population-, Scientific World Journal, cilt.2019, 2019
dc.titleThe HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
dc.typeArticle
dc.identifier.scopus85069037284
dc.identifier.doi10.1155/2019/7848314
dc.identifier.pubmed31341424
local.publication.isinternational1


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