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The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population

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dc.contributor.authorONSUN, NAHİDE
dc.contributor.authorPirmit, Serpil
dc.contributor.authorOzkaya, Dilek
dc.contributor.authorÇelik, Şirin
dc.contributor.authorRezvani, Aylin
dc.contributor.authorCENGİZ, Fatma Pelin
dc.contributor.authorKekik, Cigdem
dc.contributor.institutionauthorONSUN, NAHIDE
dc.contributor.institutionauthorREZVANİ, AYLİN
dc.contributor.institutionauthorCENGİZ, FATMA PELIN
dc.date.accessioned2020-01-19T20:59:17Z
dc.date.available2020-01-19T20:59:17Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractBackground. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.en
dc.identifier.citationONSUN N., Pirmit S., Ozkaya D., Çelik Ş., Rezvani A., CENGİZ F. P. , Kekik C., -The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population-, Scientific World Journal, cilt.2019, 2019
dc.identifier.doi10.1155/2019/7848314
dc.identifier.pubmed31341424
dc.identifier.scopus85069037284
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13417
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4ec617ef-b552-4c5b-8c2d-e767f2f2b3b9
local.publication.isinternational1
relation.isAuthorOfPublication1ebc9a95-ecf2-4c81-9f74-3c5fb32a9406
relation.isAuthorOfPublication5a967ce1-ce5a-4d41-b86b-7fcea05f68dd
relation.isAuthorOfPublication292e9ebe-735f-4346-90cf-5e0d8d0ed89d
relation.isAuthorOfPublication.latestForDiscovery292e9ebe-735f-4346-90cf-5e0d8d0ed89d
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