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Now showing 1 - 10 of 127
  • PublicationOpen Access
    Poxvirus-induced angiogenesis after a thermal burn
    (2014-09-01) Biyik Ozkaya, DİLEK; TASKIN, Banu; TAS, Betul; ASIRAN SERDAR, Zehra; Demirkesen, Cuyan; Su, Ozlem; Onsun, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE
    Orf (contagious ecthyma) is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep, goats, and oxen. Parapoxviruses are transmitted to humans through contact with an infected animal or fomites. Orf virus infections can induce ulceration, and papulonodular, pustular, or ecthymic lesions of the skin after contact with an infected animal or contaminated fomite. Rarely, orf virus provokes extensive vasculo-endothelial proliferation as a skin manifestation. Here, we present the case of an 8-year old female with poxvirus-induced vascular angiogenesis that developed 10days after a thermal burn. An 8-year-old female presented at our outpatient clinic with red swellings and a yellow-brown crust on them. After a thermal burn with hot water, she went to a clinic and the burn was dressed with nitrofurazone and covered for 2days. When the dressing was removed after 2days, nodules were seen in the burnt areas. When the clinical findings were considered with the histopathological features, a reactive vascular proliferation due to a viral agent was suspected. Following PCR, parapoxvirus ovis was detected. Viral infections such as pox virus can trigger pyogenic granulomas or pyogenic granuloma-like vascular angiogenesis. Infectious agents must be considered when dealing with pyogenic granuloma-like lesions.
  • PublicationOpen Access
    Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris
    (2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMER
    Background: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.
  • PublicationOpen Access
    The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
    (2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELIN
    Background. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.
  • PublicationMetadata only
    Verrucous Bowen’s disease on groin with dermoscopic and siascopic images
  • PublicationMetadata only
    Treatment profile of patients with moderate-to-severe psoriasis included in the Turkish national registry PSR-TR
    (2017-11-01) Onsun, NAHİDE; Baskan, E. B.; DIZMAN, DİDEM; OZKAYA, D. B.; Erkilic, A. C.; Ozarmagan, G.; Gurer, M. A.; ONSUN, NAHIDE; DİZMAN, DİDEM
  • PublicationMetadata only
    Effects of TNF inhibitors and an IL12/23 inhibitor on changes in body weight and adipokine levels in psoriasis patients: A 48-week comparative study.
    (2021-03-11T00:00:00Z) Onsun, Nahide; Akaslan, Tahsin Çağdaş; Sallahoglu, Kadriye; Gülcan, Aliye Sevdem; Bulut, Huri; Yabacı, AYŞEGÜL; ONSUN, NAHIDE; YABACI TAK, AYŞEGÜL
  • PublicationMetadata only
    Unilateral linear punctate palmar keratoderma
    (2014-05-01) Biyik Ozkaya, DİLEK; TAS, Betul; Su, Ozlem; UNAL CAKITER, Alkim; Tosuner, ZEYNEP; Demirkesen, Cuyan; Onsun, NAHİDE; BIYIK ÖZKAYA, DİLEK; SU KÜÇÜK, ÖZLEM; TOSUNER, ZEYNEP; ONSUN, NAHIDE
  • PublicationMetadata only
    Investigation of cytokine gene polymorphisms in patients with psoriasis vulgaris
    (2016-01-01T00:00:00Z) Cinar, Cigdem Kekik; Karahan, Gonca Emel; Temurhan, Sonay; Pirmit, Serpil; ONSUN, Nahide; Oguz, Fatma Savran; ONSUN, NAHIDE
    Psoriasis is associated with cutaneous and systemic overexpression of several proinflammatory cytokines. The aim of this study was to investigate the relationship between susceptibility to psoriasis and polymorphisms of tumor necrosis factor alpha (TNF-alpha), interferon gamma (INF-gamma), interleukin (IL-10), IL-6 and transforming growth factor beta (TGF-beta). Eighty-nine patients with psoriasis and 201 healthy controls were enrolled into the study. The patient group was divided into 2 subgroups as early-onset (group 1) and late-onset (group 2). The cytokine gene polymorphisms in each group were determined by polymerase chain reaction-single specific primer. When the whole and only group 1 patients were compared with the controls, TGF-beta TT/GC genotype was significantly high in the whole and group 1 patients. When we compared the group 1 and group 2, the frequency of IFN-gamma AA genotype was found to be significantly high in group 1 which lost significance after Bonferroni correction. Patients with moderate symptoms had a significantly high frequency of IL-10 GCC/GCC genotype that did not remain significant after correction. These data from our small group of patients demonstrated that the only significant difference between the whole patient group and the controls was for TGF-beta TT/GC genotype with a higher frequency in the patients. Due to the involvement of many other genes relating to the activity of Th1 cytokines, further studies are required to determine the molecular basis of the susceptibility to psoriasis.
  • PublicationOpen Access
    Demographic characteristics, aetiology, and assessment of treatment options in leukocytoclastic vasculitis.
    Introduction: Vasculitides are a heterogeneous group of diseases characterized by inflammation of the blood vessel walls. Etiological factors include infections, drugs, connective tissue diseases, and malignancies. Aim: To examine the demographic characteristics, etiological factors, and treatment options in 75 patients with leukocytoclastic vasculitis. Material and methods: The study included 75 patients diagnosed with leukocytoclastic vasculitis at our clinic. The patients’ medical records were reviewed to determine their age, sex, presence of systemic symptoms, possible etiological factors, laboratory results, types of cutaneous lesions, locations of the lesions, treatment options, and disease course. Results: There were 43 women and 32 men. Cutaneous lesions affected only the lower limbs in 60 of the 75 patients (80%) and usually presented as palpable purpura (64%, n = 48). Arthralgia (26.7%, n = 20) was the most frequent extracutaneous symptom. Of the patients with secondary vasculitis, the most common causes were infections and drugs. The mean age of the patients with Henoch-Schönlein purpura was 26.8 years. There was no significant association between age and renal, gastrointestinal, or joint involvement. Conclusions: The most common form of vasculitis in our study was cutaneous leukocytoclastic vasculitis. In most of the patients it appeared to be idiopathic. Among drugs, antibiotics were the most common etiological factor. In 4 patients, the cutaneous leukocytoclastic vasculitis behaved like the paraneoplastic syndrome.
  • PublicationMetadata only
    (2015-11-01T00:00:00Z) Onsun, Nahide; ONSUN, NAHIDE