Person: CENGİZ, FATMA PELIN
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Publication Metadata only Does verruca vulgaris affect social anxiety and self-esteem in adolescents?(2017-05-24T00:00:00Z) Unal, D; Cengiz, Fatma Pelin; Emiroglu, N; CENGİZ, FATMA PELINPublication Open Access The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population(2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELINBackground. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.Publication Metadata only Verrucous Bowen’s disease on groin with dermoscopic and siascopic images(2017-05-06T00:00:00Z) CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Metadata only Serum visfatin levels in Behcet-s disease(2015-01-01T00:00:00Z) EMİROĞLU, Nazan; CENGİZ, Fatma Pelin; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINBackground and Design: The genetic predisposition, infectious agents, various antibodies and oxidative stress has been suggested to be among the possible causes of the etiopathogenesis of Behcet-s disease (BD). Recently, a new protein called visfatin, synthesized by adipose tissue has been identified. Visfatin has been found to be associated with many cases like insulin resistance, obesity, atherosclerosis, inflammation, immunity. In this study, we aimed to evaluate the relationship between serum visfatin levels and the activity of Behcet-s disease, and determine the role of visfatin in the inflammatory process of BD.Publication Metadata only Dermoscopic and clinical features of pigmented skin lesions of the genital area.(2015-03-01T00:00:00Z) Cengiz, FATMA PELİN; EMIROGLU, NAZAN; WELLENHOF, RH; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANPublication Metadata only Dermatolojik Hastalıklarda Çinko’xxnun Önemi(2016-01-01T00:00:00Z) EMİROĞLU, NAZAN; CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINPublication Open Access Evaluation of Neopterin Level and Disease Severity in Patients with Psoriasis Vulgaris Treated with Narrowband UVB.(2019-11-01T00:00:00Z) Kemeriz, F; Cengiz, FP; Gönül, M; Emiroğlu, Nazan; Cemil, BÇ; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANBackground: Neopterin is a biochemical marker of cellular immunity. It has been reported that serum and urine neopterin levels increase in psoriasis and decrease with treatment. Nevertheless, assessment of a direct link between narrowband ultraviolet B (UVB) therapy and neopterin level in association with Psoriasis Area and Severity Index (PASI) scores has not been performed yet. We aimed to evaluate the serum neopterin level in patients with psoriasis treated with narrowband UVB therapy in association with disease severity. Materials and methods: The study included 35 patients with chronic plaque-type psoriasis who had PASI scores of >10 or below 10 but resistant to topical therapies and 30 healthy individuals. The narrowband UVB therapy was administered to the patient group (n = 35). Serum neopterin analysis was performed with an enzyme-linked immunosorbent assay method before and after treatment. Results: There was statistically significant correlation between neopterin level and PASI score in the patient group (P = 0.011). The serum neopterin level was significantly increased in patients with higher PASI score. Moreover, the serum neopterin level was found to be statistically higher in severe psoriasis group (PASI score ≥10, n = 14) than the mild-moderate group (PASI score <10, n = 21) (P = 0.001). Furthermore, a significant decrease was observed according to serum neopterin level after the narrowband UVB therapy in the remaining 20 patients who were able to comply with the scheduled therapy and follow-up procedure (P = 0.026). Conclusion: Serum neopterin levels were found to be an useful marker for evaluating disease severity and efficacy of narrowband UVB treatment. Thus, our findings may provide a new approach with the management of disease and follow-up strategies in patients with psoriasis.Publication Metadata only A case of lichen aureus treated with tacrolimus Takrolimusla tedavi edilen bir liken aureus olgusu(2014-01-01T00:00:00Z) Emiroǧlu, NAZAN; Cengiz, FATMA PELİN; KEMERIZ, Funda; EMİROĞLU, NAZAN; CENGİZ, FATMA PELINPublication Metadata only Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides(2015-01-01T00:00:00Z) Cengiz, FATMA PELİN; Emiroglu, NAZAN; CENGİZ, FATMA PELIN; EMİROĞLU, NAZANBACKGROUND: Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, is more common in patients aged 45-55.Publication Open Access Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi(2017-02-01) Cengiz, FATMA PELİN; Emiroglu, NAZAN; OZKAYA, Dilek Biyik; Onsun, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEBackground: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Methods: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination. Results: Of the subjects, 57.4% were aged less than 16 years, 42.6% were aged 16 and more. Of the nevi, 26 had reticular pattern (24.1%), 35 had globular pattern (32.4%), 13 had reticular-globular pattern (12.0%), 16 had homogeneous pattern (14.8%), 6 had reticular-homogeneous pattern (5.6%), 2 had globular-homogeneous pattern (1.9%), 7 had cobblestone pattern (6.5%), 3 had reticular patchy pattern (2.8%). Atypical dots and globules, focal hypopigmentation and perifollicular hypopigmentation are the most common dermoscopic features of CMN. The rarest dermoscopic feature is the blue-whitish veil. Conclusion: Most of the dermoscopic features related with dysplastic nevi up to the present, such as atypical dots and globules, focal hypopigmentation, perifollicular hypopigmentation were observed in CMN, in our study. Congenital nevus and dysplastic nevi may share the same dermoscopic features, therefore it is important to know it is found at birth or not.