The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population

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2019-01-01Author
Pirmit, SerpilRezvani, Aylin
Çelik, Şirin
Ozkaya, Dilek
ONSUN, NAHİDE
Kekik, Cigdem
CENGİZ, Fatma Pelin
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Background. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental
factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge,
there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study
aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145
age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and
joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system.
Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and
HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis
patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for
systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the
second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited
as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of
psoriasis.
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