Publication: Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy.
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Date
2014-06-28
Authors
IDIZ, O
Aysan, E
FIRAT, D
ERSOY, YELİZ EMİNE
CENGIZ, MB
AKBULUT, H
ISıK, A
MUSLUMANOGLU, M
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Abstract
We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after
thyroidectomy.
Material/Method: We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups:
0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions
were evaluated macroscopically and microscopically.
Results: The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group,
and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52,
and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were
significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups
(p>0.05).
Conclusions: Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is
more effective.
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Citation
IDIZ O., Aysan E., FIRAT D., ERSOY Y. E. , CENGIZ M., AKBULUT H., ISıK A., MUSLUMANOGLU M., -Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy.-, Medical science monitor : international medical journal of experimental and clinical research, cilt.20, ss.1090-4, 2014