Publication: Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3
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Date
2019-01-01
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HATİBOĞLU, MUSTAFA AZİZ
KOÇYİĞİT, ABDÜRRAHİM
GÜLER, ERAY METİN
Akdur, Kerime
Khan, Imran
Nalli, Arife
Karataş, Ersin
TÜZGEN, SAFFET
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Abstract
BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.
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HATİBOĞLU M. A. , KOÇYİĞİT A., GÜLER E. M. , Akdur K., Khan I., Nalli A., Karataş E., TÜZGEN S., -Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3-, WORLD NEUROSURGERY, cilt.128, ss.570-581, 2019