Publication: Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3
HATİBOĞLU, MUSTAFA AZİZ
GÜLER, ERAY METİN
BACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.
HATİBOĞLU M. A. , KOÇYİĞİT A., GÜLER E. M. , Akdur K., Khan I., Nalli A., Karataş E., TÜZGEN S., -Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3-, WORLD NEUROSURGERY, cilt.128, ss.570-581, 2019