• Home
  • About
  • Policies
  • Contact
    • English
    • Türkçe
  • English 
    • English
    • Türkçe
  • Login
Advanced Search
View Item 
  •   Home
  • Tüm Akademik Yayınlar
  • Yayınlar - Eserler
  • View Item
  •   Home
  • Tüm Akademik Yayınlar
  • Yayınlar - Eserler
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.

Thumbnail
View/Open
68- Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.pdf (133.0Kb)
Date
2017-12-01
Author
Kekik, Çinar
ALTINTAŞ, A
Uysal, ÖMER
UZAN, M
ÖZKARA, Ç
Sohtaoğlu, Sevindik
Savran, Oğuz
Advisor
Type
Article
Metadata
Show full item record
Abstract
Objective: Hippocampal sclerosis (HS) is the most common pathological substrate associated with mesial temporal lobe epilepsy (MTLE), where inflammatory processes are known to play an increasingly important role in the pathogenesis. To further investigate the role of the immune system, both cytokine gene polymorphisms and human leukocyte antigen (HLA) genotyping in patients with MTLE-HS were investigated. Methods: The DNA samples of 100 patients with MTLE-HS and 201 healthy individuals were genotyped for cytokines (IL-6,IL-10, TNF-α, TGF-β1 and IFN-γ) and HLA using polymerase chain reaction (PCR)-SSP and SSO methods. The results were statistically analyzed in patient and healthy control groups and then according to the presence of febrile seizures (FS) in the patient group. Results: Analysis of cytokine genotyping did not reveal any significant difference between patients with MTLE-HS and controls and patients with or without FS. However, the HLA DRB1*13 allele was found to be more frequent in the patient population after Bonferroni correction. Conclusion: This study suggests the possible role of HLA in the pathogenesis of MTLE-HS, although it failed to show any relationship with the cytokine system. However, data regarding the role of HLA are still lacking, and further studies are necessary to verify our results.
Subject
ALTINTAŞ A., ÖZKARA Ç., Sohtaoğlu S., UZAN M., Kekik Ç., Uysal Ö., Savran O., -Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.-, Noro psikiyatri arsivi, cilt.54, ss.350-353, 2017
URI
https://hdl.handle.net/20.500.12645/8299
Collections
  • PubMed İndeksli Yayın Koleksiyonu [3700]
  • Scopus İndeksli Yayınlar Koleksiyonu [4458]
  • WoS İndeksli Yayınlar Koleksiyonu [5222]
  • Yayınlar - Eserler [10057]

BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS


Bezmialem Kütüphane


OpenAccess@BVU validated by OpenAIRE

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageRightsby AdvisorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageRightsby Advisor

My Account

LoginRegister

BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS