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Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.

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dc.contributor.authorALTINTAŞ, A
dc.contributor.authorÖZKARA, Ç
dc.contributor.authorSohtaoğlu, Sevindik
dc.contributor.authorUZAN, M
dc.contributor.authorKekik, Çinar
dc.contributor.authorUysal, ÖMER
dc.contributor.authorSavran, Oğuz
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T21:51:39Z
dc.date.available2019-10-05T21:51:39Z
dc.date.issued2017-12-01
dc.description.abstractObjective: Hippocampal sclerosis (HS) is the most common pathological substrate associated with mesial temporal lobe epilepsy (MTLE), where inflammatory processes are known to play an increasingly important role in the pathogenesis. To further investigate the role of the immune system, both cytokine gene polymorphisms and human leukocyte antigen (HLA) genotyping in patients with MTLE-HS were investigated. Methods: The DNA samples of 100 patients with MTLE-HS and 201 healthy individuals were genotyped for cytokines (IL-6,IL-10, TNF-α, TGF-β1 and IFN-γ) and HLA using polymerase chain reaction (PCR)-SSP and SSO methods. The results were statistically analyzed in patient and healthy control groups and then according to the presence of febrile seizures (FS) in the patient group. Results: Analysis of cytokine genotyping did not reveal any significant difference between patients with MTLE-HS and controls and patients with or without FS. However, the HLA DRB1*13 allele was found to be more frequent in the patient population after Bonferroni correction. Conclusion: This study suggests the possible role of HLA in the pathogenesis of MTLE-HS, although it failed to show any relationship with the cytokine system. However, data regarding the role of HLA are still lacking, and further studies are necessary to verify our results.en
dc.identifier10.1016/j.polymer.2010.01.005
dc.identifier.citationALTINTAŞ A., ÖZKARA Ç., Sohtaoğlu S., UZAN M., Kekik Ç., Uysal Ö., Savran O., -Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.-, Noro psikiyatri arsivi, cilt.54, ss.350-353, 2017
dc.identifier.doi10.5152/npa.2016.12678
dc.identifier.pubmed29321710
dc.identifier.scopus85040033181
dc.identifier.trdizinISSN: 1309-4866 / 1309-4866
dc.identifier.trdizinISSN: 1309-4866 / 1309-4866
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8299
dc.identifier.wosWOS:000419359800013
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePOLYMER
local.avesis.idce967ff7-1892-47ba-bc20-78e4611afee8
local.avesis.response8175
local.publication.isinternational1
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
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