Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?
Date
2019-03-01Author
EKİN, ZÜBEYDE YILDIRIMİLBEY, YUSUF ÖZLEM
EKİN, RAHMİ GÖKHAN
SILAY, MESRUR SELÇUK
KIZILTAN, HURİYE ŞENAY
ÇAY, ALİ
MİRAPOĞLU, SEMİH LÜTFİ
ÇOBAN, GANİME
AYDOĞDU, İBRAHİM
SEMERCİ, MEHMET BÜLENT
Advisor
Type
Metadata
Show full item recordAbstract
Objective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)‑induced testicular damage.
Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C),
(2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid‑reactive
substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated.
Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS
level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared
to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level.
Furthermore, testicular weight and Johnsen score were increased with OT.
Conclusions: The present study showed that OT is protective and therapeutic in radiation‑induced testicular damage. OT may be
beneficial to the patients who underwent RT.
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