Oxidative Stress in Children with Chronic Spontaneous Urticaria

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Date
2016-01-01Author
Guler, NerminOzkaya, EMİN
Kocyigit, ABDÜRRAHİM
Ozceker, Deniz
Tamay, Zeynep
DILEK, Fatih
Yazici, MEBRURE
KESGIN, Siddika
Advisor
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The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has
been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in
the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive
evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status
(TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L
(interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference
between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased
significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001).
Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma
oxidative stress markers are positively correlated with disease activity
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