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Oxidative Stress in Children with Chronic Spontaneous Urticaria

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Date
2016-01-01
Author
Guler, Nermin
Ozkaya, EMİN
Kocyigit, ABDÜRRAHİM
Ozceker, Deniz
Tamay, Zeynep
DILEK, Fatih
Yazici, MEBRURE
KESGIN, Siddika
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Article
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Abstract
The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity
Subject
DILEK F., Ozceker D., Ozkaya E., Guler N., Tamay Z., KESGIN S., Yazici M., Kocyigit A., -Oxidative Stress in Children with Chronic Spontaneous Urticaria-, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016
URI
https://hdl.handle.net/20.500.12645/4662
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  • Yayınlar - Eserler [9983]

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS