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Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis

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Date
2018-01-01
Author
Kocak, Ilker
Yildirim, YAVUZ SELİM
AYDIN, Mehmet Serif
Kocyigit, ABDÜRRAHİM
Senturk, EROL
Esrefoglu, MUKADDES
Guler, ERAY METİN
Ozturan, ORHAN
Dogan, REMZİ
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Type
Article
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Abstract
The aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment. In the biochemical examination, on the surface of the tissue tumor necrosis factor (TNF) interferon (IFN), interleukin (IL)-5, IL-13, as well as IL-2, IL-4, IL-17A, and IgE were studied. Histologically, ciliary loss, increase of goblet cells, vascular congestion, and the degree of eosinophil infiltration were rated. In all treatment groups, on average, a significant reduction in all histological and biochemical values was found compared to the positive control group. Comparing each of the three cyclosporine-using groups with the group of nasal corticosteroid did not show any significant difference in the average scores. Cyclosporine nasal drops are effective to be used in an animal model of experimental allergic rhinitis without systemic effects.
Subject
Senturk E., Yildirim Y. S. , Dogan R., Ozturan O., Guler E. M. , AYDIN M. S. , Kocyigit A., Esrefoglu M., Kocak I., -Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis-, EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.275, ss.117-124, 2018
URI
https://hdl.handle.net/20.500.12645/4610
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  • Yayınlar - Eserler [10056]

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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS