Publication: Does intra-articular fracture change the lubricant content of synovial fluid?
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Date
2015-06-03
Authors
CEYLAN, Hasan H.
Erdil, Mehmet
Polat, Gokhan
Kara, DENİZ
KILIC, Elif
Kocyigit, ABDÜRRAHİM
Tuncay, Ibrahim
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Abstract
Background: Lubrication function is impaired and the lubricant content of synovial fluid (SF) changes immediately
after plateau tibia fractures. Here, we aimed to analyze the lubricant content of SF at chronic term following plateau
tibia fracture.
Methods: Forty-eight surgically treated patients without joint incongruency (<2 mm displacement) were included in
the study. Joint aspiration had been possible in 16 of the participants. However, sampling could be made from healthy
knees in only ten of these patients. Twenty-six SF samples (16 injured knees, 10 healthy knees) were analyzed for
concentrations of hyaluronic acid (HA), proteoglycan-4 (PRG4), TNF-α, IL-1β, and IL-6.
Results: The group of experimental samples were obtained at a mean of 31 (12–66) months after injury from patients
with a mean age of 45.1 (32–57) years. There were no relationships detected between biochemical analysis results and
patient ages, sexes, postoperative time, and fracture type. After excluding six patients for whom we could not sample
from their healthy knee, ten patients’ values were compared with paired Wilcoxon signed rank test and no significant
differences detected between the healthy and injured knee in terms of the SF concentrations of HA and PRG4
(p = 0.225 and 0.893, respectively). Similarly, there were no statistically significant differences in SF sample
concentrations of TNF-α, IL-1β, and IL-6 between healthy and injured knees.
Conclusions: Despite acute changes, the long-term concentrations of HA and PRG4 were similar after plateau tibial
fracture. We could not detect any concentration level differences between healthy knees and injured knees regarding
HA and PRG4 in the long-term follow-up.
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Keywords
Hyaluronan, Lubricant, Synovial fluid, Fracture, Proteoglycan
Citation
CEYLAN H. H. , Erdil M., Polat G., Kara D., KILIC E., Kocyigit A., Tuncay I., -Does intra-articular fracture change the lubricant content of synovial fluid?-, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, cilt.10, 2015