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Does intra-articular fracture change the lubricant content of synovial fluid?

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dc.contributor.authorCEYLAN, Hasan H.
dc.contributor.authorErdil, Mehmet
dc.contributor.authorPolat, Gokhan
dc.contributor.authorKara, DENİZ
dc.contributor.authorKILIC, Elif
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorTuncay, Ibrahim
dc.contributor.institutionauthorKARA, DENİZ
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorTUNCAY, İBRAHİM
dc.date.accessioned2019-10-05T12:42:30Z
dc.date.available2019-10-05T12:42:30Z
dc.date.issued2015-06-03
dc.description.abstractBackground: Lubrication function is impaired and the lubricant content of synovial fluid (SF) changes immediately after plateau tibia fractures. Here, we aimed to analyze the lubricant content of SF at chronic term following plateau tibia fracture. Methods: Forty-eight surgically treated patients without joint incongruency (<2 mm displacement) were included in the study. Joint aspiration had been possible in 16 of the participants. However, sampling could be made from healthy knees in only ten of these patients. Twenty-six SF samples (16 injured knees, 10 healthy knees) were analyzed for concentrations of hyaluronic acid (HA), proteoglycan-4 (PRG4), TNF-α, IL-1β, and IL-6. Results: The group of experimental samples were obtained at a mean of 31 (12–66) months after injury from patients with a mean age of 45.1 (32–57) years. There were no relationships detected between biochemical analysis results and patient ages, sexes, postoperative time, and fracture type. After excluding six patients for whom we could not sample from their healthy knee, ten patients’ values were compared with paired Wilcoxon signed rank test and no significant differences detected between the healthy and injured knee in terms of the SF concentrations of HA and PRG4 (p = 0.225 and 0.893, respectively). Similarly, there were no statistically significant differences in SF sample concentrations of TNF-α, IL-1β, and IL-6 between healthy and injured knees. Conclusions: Despite acute changes, the long-term concentrations of HA and PRG4 were similar after plateau tibial fracture. We could not detect any concentration level differences between healthy knees and injured knees regarding HA and PRG4 in the long-term follow-up.en
dc.identifier
dc.identifier.citationCEYLAN H. H. , Erdil M., Polat G., Kara D., KILIC E., Kocyigit A., Tuncay I., -Does intra-articular fracture change the lubricant content of synovial fluid?-, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, cilt.10, 2015
dc.identifier.doi10.1186/s13018-015-0232-6
dc.identifier.pubmed26037740
dc.identifier.scopus84931275337
dc.identifier.urihttps://hdl.handle.net/20.500.12645/361
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465465/
dc.identifier.wosWOS:000356059100001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectHyaluronan
dc.subjectLubricant
dc.subjectSynovial fluid
dc.subjectFracture
dc.subjectProteoglycan
dc.titleDoes intra-articular fracture change the lubricant content of synovial fluid?
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameDoktor
local.avesis.id0581a07e-9dcc-487e-a781-132fd98e5750
local.avesis.response231
local.org.facultyTıp Fakültesi
local.publication.isinternational1
relation.isAuthorOfPublicationd041eda2-3259-47f5-ac89-cc1a76785610
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication3e190620-9fed-4601-b2d2-56f6d609e355
relation.isAuthorOfPublication.latestForDiscovery3e190620-9fed-4601-b2d2-56f6d609e355
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