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Flavonoid constituents of Sideritis caesarea

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Date
2013-01-01
Author
Halfon, Belkis
Topcu, GÜLAÇTI
Ciftci, Ece
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Type
Article
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Abstract
The acetone extract of the aerial parts of Sideritis caesarea Duman, Aytac & Baser (Lamiaceae) afforded the flavonoids penduletin (1) and apigenin (2) and 6 glycosylated flavonoids, 4--O-methyl-isoscutellarein-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 --O-acetyl-beta-D-glucopyranoside (3), 4--O-methylhypolaetin-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 --O-acetyl-beta-D-glucopyranoside (4), isoscutellarein-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 --O-acetyl-beta-D-glucopyranoside (5), isoscutellarein-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (6), 4--O-methylhypolaetin-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (7), and hypolaetin-7-O-[6 --O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (8). The compounds were identified by the use of 1D- and 2D-NMR and UV spectroscopic techniques and by comparisons with the reported data. The acetyl-cholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of the acetone, methanol, and water extracts of the plant and of the flavones penduletin and apigenin were evaluated at 200 mu g/mL. The water extract exhibited better activity against the enzyme AChE as compared to both the acetone and the methanol extracts. Penduletin (1) showed significant activity against BChE (66.58%) while apigenin (2) showed weak activity against both enzymes.
Subject
Halfon B., Ciftci E., Topcu G., -Flavonoid constituents of Sideritis caesarea-, TURKISH JOURNAL OF CHEMISTRY, cilt.37, ss.464-472, 2013
URI
https://hdl.handle.net/20.500.12645/2792
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS