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Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease

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Lamiaceae Family Plants as a Potential Anticholinesterase Source.pdf (673.2Kb)
Date
2014-02-01
Author
KUŞMAN, TUBA
TOPÇU, GÜLAÇTI
Advisor
Type
Article
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Abstract
Alzheimer’s disease (AD) is one of the most common and progressive neurodegenerative disorders with dementia in the world. The precise causes of AD are not fully understood yet, although several important features of its pathophysiology are well described. Current AD treatment is symptomatic and is mainly, but not exclusively, focused on the inhibition of cholinesterases (ChEs). There are four cholinesterase inhibitors approved by the U.S. Food and Drug Administration (FDA): tacrine, donepezil, rivastigmine, and galantamine. Among them, galantamine is a natural drug, and rivastigmine is a derivative of the natural drug physostigmine. In addition, only an NMDA (N-methyl- D-aspartate) receptor antagonist, memantine, is also approved by the FDA in the treatment of patients with moderate to severe AD. However, none of them provides a satisfactory treatment for Alzheimer’s disease, and studies are still going on to find new potential drugs from both synthetic chemicals and natural sources. In this review, studies on the discovery of new cholinesterase inhibitors from natural sources, particularly from Lamiaceae family plants were evaluated, and a number of terpenoids and phenolics/flavonoids isolated are presented as potential drugs in the treatment of Alzheimer’s disease.
Subject
Alzheimer’s disease
Lamiaceae Family Plants
Review
URI
https://hdl.handle.net/20.500.12645/1687
http://www.bezmialemscience.org/archives/archive-detail/article-preview/lamiaceae-family-plants-as-a-potential-anticholine/20440
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS