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Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease

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dc.contributor.authorTOPÇU, GÜLAÇTI
dc.contributor.authorKUŞMAN, TUBA
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorKUŞMAN, TUBA
dc.date.accessioned2019-10-05T13:14:17Z
dc.date.available2019-10-05T13:14:17Z
dc.date.issued2014-02-01
dc.description.abstractAlzheimer’s disease (AD) is one of the most common and progressive neurodegenerative disorders with dementia in the world. The precise causes of AD are not fully understood yet, although several important features of its pathophysiology are well described. Current AD treatment is symptomatic and is mainly, but not exclusively, focused on the inhibition of cholinesterases (ChEs). There are four cholinesterase inhibitors approved by the U.S. Food and Drug Administration (FDA): tacrine, donepezil, rivastigmine, and galantamine. Among them, galantamine is a natural drug, and rivastigmine is a derivative of the natural drug physostigmine. In addition, only an NMDA (N-methyl- D-aspartate) receptor antagonist, memantine, is also approved by the FDA in the treatment of patients with moderate to severe AD. However, none of them provides a satisfactory treatment for Alzheimer’s disease, and studies are still going on to find new potential drugs from both synthetic chemicals and natural sources. In this review, studies on the discovery of new cholinesterase inhibitors from natural sources, particularly from Lamiaceae family plants were evaluated, and a number of terpenoids and phenolics/flavonoids isolated are presented as potential drugs in the treatment of Alzheimer’s disease.en
dc.identifier
dc.identifier.citationTOPÇU G., KUŞMAN T., -Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease-, BEZMIALEM SCIENCE, cilt.1, ss.1-25, 2014
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1687
dc.identifier.urihttp://www.bezmialemscience.org/archives/archive-detail/article-preview/lamiaceae-family-plants-as-a-potential-anticholine/20440
dc.identifier.wosWOS:000218637100001
dc.language.isoen
dc.subjectAlzheimer’s disease
dc.subjectLamiaceae Family Plants
dc.subjectReview
dc.titleLamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer’s Disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTÜRK PATOLOJİ DERGİSİ
local.avesis.id282cf6dd-5d4a-4de4-9b4c-cbe2acc7bc6a
local.avesis.response1557
local.org.facultyTıp Fakültesi
local.publication.isinternational1
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublicationdd1224a4-1103-402e-8b37-f91f9eb3162b
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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