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A New HPLC Method with Fluorescence Detection for the Determination of Memantine in Human Plasma

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Date
2013-01-01
Author
Tekkeli, Serife Evrim Kepekci
Toker, Sidika Erturk
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Type
Article
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Abstract
A sensitive and selective HPLC method with fluorometric detection was developed for the determination of memantine in human plasma and applied to a pharmacokinetic study. Memantine was precolumn derivatized with 9-fluorenylmethyl chloroformate, and the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile-10 mM orthophosphoric acid containing 1 mL/L triethylamine with gradient elution. The method was based on the measurement of the derivative using fluorescence detection at 310 nm with excitation at 260 nm. The calibration curve was linear over the range 1.0-50.0 ng/mL. LOD and LOQ were found to be 0.3 and 1.0 ng/mL, respectively. Intraday and interday RSD values were less than 3.39%.
Subject
Tekkeli S. E. K. , Toker S. E. , -A New HPLC Method with Fluorescence Detection for the Determination of Memantine in Human Plasma-, JOURNAL OF AOAC INTERNATIONAL, cilt.96, ss.52-55, 2013
URI
https://hdl.handle.net/20.500.12645/1654
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BEZMIALEM VAKIF UNIVERSITY

About us |Policies | Library | Contact us | Send Feedback | Sitemap | Admin

Bezmialem Vakıf Üniversitesi, Adnan Menderes Bulvarı Vatan Caddesi 34093 Fatih, İstanbul / TURKEY
Copyright © Bezmialem Vakıf Üniversitesi

Creative Commons Lisansı
Bezmialem Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

OpenAccess@BVU

Support by  UNIREPOS