Publication:
A New HPLC Method with Fluorescence Detection for the Determination of Memantine in Human Plasma

Simple item page
dc.contributor.authorTekkeli, Serife Evrim Kepekci
dc.contributor.authorToker, Sidika Erturk
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.date.accessioned2019-10-05T13:13:36Z
dc.date.available2019-10-05T13:13:36Z
dc.date.issued2013-01-01
dc.description.abstractA sensitive and selective HPLC method with fluorometric detection was developed for the determination of memantine in human plasma and applied to a pharmacokinetic study. Memantine was precolumn derivatized with 9-fluorenylmethyl chloroformate, and the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile-10 mM orthophosphoric acid containing 1 mL/L triethylamine with gradient elution. The method was based on the measurement of the derivative using fluorescence detection at 310 nm with excitation at 260 nm. The calibration curve was linear over the range 1.0-50.0 ng/mL. LOD and LOQ were found to be 0.3 and 1.0 ng/mL, respectively. Intraday and interday RSD values were less than 3.39%.
dc.identifier10.1007/s00247-003-0946-1
dc.identifier.citationTekkeli S. E. K. , Toker S. E. , -A New HPLC Method with Fluorescence Detection for the Determination of Memantine in Human Plasma-, JOURNAL OF AOAC INTERNATIONAL, cilt.96, ss.52-55, 2013
dc.identifier.doi10.5740/jaoacint.09-133
dc.identifier.scopus84874083816
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1654
dc.identifier.wosWOS:000315254300010
dc.language.isoen
dc.titleA New HPLC Method with Fluorescence Detection for the Determination of Memantine in Human Plasma
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePEDIATRIC RADIOLOGY
local.avesis.id278e6c45-6cb9-441a-806f-90a5e4d5b680
local.avesis.response1524
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication.latestForDiscovery837d5047-762e-43db-b252-9f3d1399378f
Files
Collections
Yayınlar - Eserler