Publication:
The Role of Beta-3-Adrenoceptors in Autonomic Nervous System

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Date
2013-12-01T00:00:00Z
Authors
Aksu, Ugur
BELCE, Ahmet
DEMİRCİ TANSEL, Cihan
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Abstract
Catecholamines play a regulatory role in the cardiovascular system, primarily via beta (1-2)-adrenoreceptors (AR). However, in the late 1980s, the cloning of a third beta-AR subtype (beta 3-AR) in the heart has altered the conventional view on the regulation of heart function via the betaadrenergic receptors. Additionally, in blood vessels, beta 3-AR was shown to produce relaxation. Currently, the physiological role of beta 3-AR is not clearly known. Hence, the purpose of this review is to summarize the physiological evidences supporting the functional roles of beta 3-AR in various tissues, particularly cardiac and vascular. In addition, this review discusses the potential role of beta 3-AR in obesity and insulin resistance and emphasizes their putative involvement as new therapeutic targets.
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Beta-3-Adrenoceptors
Citation
Aksu U., BELCE A., DEMİRCİ TANSEL C., -The Role of Beta-3-Adrenoceptors in Autonomic Nervous System-, BEZMIALEM SCIENCE, cilt.1, ss.16-20, 2013
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