Person: BELCE, AHMET
Now showing 1 - 7 of 7
- PublicationMetadata onlyGender and chronological age affect erythrocyte membrane oxidative indices in citrate phosphate dextrose adenine-formula 1 (CPDA-1) blood bank storage condition.(2016-07-01) ERMAN, H; AKSU, U; Belce, AHMET; ATUKEREN, P; UZUN, D; CEBE, T; KANSU, ABDULLAH; GELIŞGEN, R; USLU, E; AYDıN, S; ÇAKATAY, U; BELCE, AHMET; KANSU, ABDULLAH
- PublicationMetadata onlyThe effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer-s disease model(2017-08-01T00:00:00Z) Erdogan, Mehmet Evren; AYDIN, Seval; YANAR, Karolin; Mengi, Murat; Kansu, Ahmet Dogukan; Cebe, Tamer; BELCE, Ahmet; Celikten, Mert; ÇAKATAY, Ufuk; BELCE, AHMETWhile the deterioration of insulin-glucose metabolism (IGM), impaired redox homeostasis (IRH), beta-amyloid accumulation was reported in Sporadic Alzheimer-s Disease (SAD) model, aforementioned factors related to lipoic acid administration and anthropometric indexes (AIs) are not yet studied with integrative approach. beta-amyloid accumulation, redox homeostasis biomarkers and AIs are investigated in SAD model. Streptozotocin-induced inhibition of insulin-signaling cascade but not GLUT-2 and GLUT-3 transporters takes a role in beta-amyloid accumulation. Inhibition types are related to IRH in cortex, hippocampus and systemic circulation. Lipoic acid (LA) shows both antioxidant and prooxidant effect according to the anatomical location. LA administration also leads to improved AIs during GLUT-2 inhibition and cortical redox status in GLUT-3 inhibited group. Optimal LA action could be possible if its redox behavior is balanced to antioxidant effect. Diagnostic usage of systemic IRH parameters as biomarkers and their possible correlations with deteriorated IGM should be investigated.
- PublicationOpen AccessEffect of Dexamethasone in Mediating Oxidative Stress Induced by Sodium Nitroprusside on Frog Sciatic Nerve Action Potentials(2013-12-01T00:00:00Z) Aksu, Ugur; Atukeren, Pinar; Terzioglu, Duygu; BELCE, Ahmet; DEMİRCİ TANSEL, Cihan; BELCE, AHMETObjective: High concentrations of nitric oxide cause a neurotoxic effect on nerve action potentials. Although glucocorticoids can decrease that effect, the degree of mediation is not known. This study determined the effect of dexamethasone on frog sciatic nerve axon fibers subjected to in vitro oxidative stress.
- PublicationMetadata onlyCaloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain(2019-03-01T00:00:00Z) YANAR, Karolin; Simsek, Bahadir; Cayli, Nisanur; Bozkir, Haktan Ovul; MENGİ, MURAT; BELCE, Ahmet; AYDIN, Seval; ÇAKATAY, Ufuk; BELCE, AHMETDespite recent studies have shown that caloric restriction (CR) could improve some functional loss associated with brain aging, the biochemical effects of CR on brain aging are still not well understood on a quantifiable biochemical basis, including whether CR could be protective when started around middle adulthood, when age-related neurodegenerative diseases are thought to set in. Therefore, in the light of more than ever aging societies and increasing neurodegenerative diseases, we aimed to test the biochemical effects of CR on redox homeostasis in different parts of male Sprague-Dawley rat brain by using the biomarkers we consistently validated in our previous work (TOS, PCO, AOPP, AGEs, sRAGE, P-SH, LHPs, 4-HNE, TAS, Cu, Zn-SOD). Our results indicate that oxidative stress biomarkers are lower in CR group, implying a more favorable redox status that has been previously shown to be correlated with better neural function.
- PublicationOpen AccessThe Role of Beta-3-Adrenoceptors in Autonomic Nervous System(2013-12-01T00:00:00Z) Aksu, Ugur; BELCE, Ahmet; DEMİRCİ TANSEL, Cihan; BELCE, AHMETCatecholamines play a regulatory role in the cardiovascular system, primarily via beta (1-2)-adrenoreceptors (AR). However, in the late 1980s, the cloning of a third beta-AR subtype (beta 3-AR) in the heart has altered the conventional view on the regulation of heart function via the betaadrenergic receptors. Additionally, in blood vessels, beta 3-AR was shown to produce relaxation. Currently, the physiological role of beta 3-AR is not clearly known. Hence, the purpose of this review is to summarize the physiological evidences supporting the functional roles of beta 3-AR in various tissues, particularly cardiac and vascular. In addition, this review discusses the potential role of beta 3-AR in obesity and insulin resistance and emphasizes their putative involvement as new therapeutic targets.
- PublicationMetadata onlyAmeliorative Effects of Testosterone Administration on Renal Redox Homeostasis in Naturally Aged Rats.(2015-08-01T00:00:00Z) YANAR, K; ATUKEREN, P; CEBE, T; KUNBAZ, A; OZAN, T; KANSU, ABDULLAH; DURMAZ, S; GÜLEÇ, V; Belce, AHMET; AYDıN, S; ÇAKATAY, U; RIZVI, SI; KANSU, ABDULLAH; BELCE, AHMET
- PublicationMetadata onlyGalactose-induced Aging Model in Rat Testicular Tissue(2018-07-01T00:00:00Z) AYDIN, Seval; YANAR, Karolin; Simsek, Bahadir; Cebe, Tamer; Sitar, Mustafa Erinc; BELCE, Ahmet; ÇAKATAY, Ufuk; BELCE, AHMETObjective: To examine whether the D-galactose induced aging model is an appropriate model for further aging research.